The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/hepatitis C virus coinfected patients

Fibrosis progression in chronic hepatitis C in patients coinfected with human immunodeficiency virus and hepatitis C virus

“…In the study of Picelli et al (5) that was cited in this letter to the editor, the associations between HPA-1, -3, and -5 systems and fi brosis progression were investigated in patients with HIV/ HCV coinfection. When comparing patients with HIV/HCV coinfection and either lower stages of fi brosis (F1/F2-Group 1) or higher stages of fi brosis (F3/F4-Group 2), Picelli et al (1) observed no deviations from the Hardy-Weinberg equilibrium in the HPA systems that were evaluated. No differences were observed between G1 and G2 according the distributions of the allelic and genotypic frequencies of the HPA systems.…”

“…Rejane Maria Tommasini Grotto [1], [2] and Maria Inês de Moura Campos Pardini [1], [3] [1]. Fibrosis progression is a complex event in patients with chronic hepatitis C. Fibrosis progression occurs when the components of the extracellular matrix are deposited in excess in the liver, leading to the substitution of functional hepatic tissue with non-functional fi brotic tissue.…”

“…However, these study were conducted with patients who were monoinfected with hepatitis C virus (HCV). The study by Picelli et al (1) is the fi rst to have evaluated the infl uence of HPA polymorphism in fi brosis progression using patients with human immunodefi ciency virus and hepatitis C virus (HIV/HCV) coinfection. Although the study included 36 patients, they were representative of the entire population of HIV/HCV coinfected patients who were assisted at the Specialized Outpatient Service of Domingos Alves Meira and at the Department of Internal Medicine, Gastroenterology Division, Botucatu School of Medicine [São Paulo State University (UNESP), Botucatu, SP, Brazil].…”

“…Thus, the role of HPA system polymorphisms in fi brosis progression was differed for patients with HCV monoinfection (5) and those with HIV/HCV coinfection (1) .…”

Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients

“…[21,22] Likewise, the association of the host genetic polymorphisms with the progression of hepatic fibrosis is different in HCV mono-infected patients compared to HIV/HCV coinfected patients. [23]…”