The Absorption Into Burned Skin of Sulfamylon Acetate From 5 Per Cent Aqueous Solution

Harrison, Howard N.; Bales, Harold W.; Jacoby, F. C.

doi:10.1097/00005373-197211000-00010

Cited by 22 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the high osmolality of 10% Sulfamylon cream was associated with neoeschar formation and wound pain [ 112 , 115 ]. Several animal experiments and clinical studies demonstrated that the use of 5% Sulfamylon solution dressing provided a better result with less side effects [ 116 , 117 , 118 ]. Finally, the 5% Sulfamylon became widely used for burn wound treatment [ 108 ].…”

Section: Surgical Approachesmentioning

confidence: 99%

Review of History of Basic Principles of Burn Wound Management

2022

View full text Add to dashboard Cite

Thermal energy is an essential and useful resource to humans in modern society. However, a consequence of using heat carelessly is burns. Burn injuries have various causes, such as exposure to flame, radiation, electrical, and chemical sources. In this study, we reviewed the history of burn wound care while focusing on the basic principles of burn management. Through this review, we highlight the need for careful monitoring and customization when treating burn victims at each step of wound care, as their individual needs may differ. We also propose that future research should focus on nanotechnology-based skin grafts, as this is a promising area for further improvement in wound care.

show abstract

Section: Surgical Approachesmentioning

confidence: 99%

Review of History of Basic Principles of Burn Wound Management

2022

View full text Add to dashboard Cite

show abstract

“…Drug localization in the burn wound reduces systemic drug toxicity and increases the antimicrobial effectiveness. Mafenide acetate absorption from a 5% aqueous solution into excised human and rat burned skin was studied using C14-labeled mafenide acetate [24]. They reported that final concentration of mafenide acetate in the human and rat burned tissues was similar and concluded that rat skin is useful mode due to similarity to human tissue.…”

Section: Discussionmentioning

confidence: 99%

the THE EFFECT OF CHITOSAN COATING ON MAFENIDE ACETATE-LOADED LIPOSOME CHARACTERIZATION AND DELIVERY THROUGH BURNED RAT SKIN

Makhmalzadeh

Zamin

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Mafenide acetate has appropriate antibacterial activity against Gram-positive bacteria isolated from the eschar surface. This drug has a high permeability through eschar which causes not only low concentration in the target place but also systemic toxicity. The aim of this study was localization of mafenide acetate into the eschar by chitosome. Methods: In this study, liposomes are prepared with thin-layer hydration method and then covered by chitosan film. Based on full factorial design, different formulation was prepared and characterized and the selected formulation was applied on burned rat skin. Results: Chitosan decreased membrane fluidity by interaction with phospholipid and cholesterol that induced lower drug loading efficiency and higher particle size of chitosomal formulation in comparison with liposomal formulations. Mucoadhesive and slow drug release property of chitosomes provided higher drug concentration into the eschar. Conclusion: Impairment barrier property of eschar can be treated by the application of chitosomes. Chitosomes provided more drug concentration into the eschar and so are better vehicles for burn wound treatment in comparison with liposomes.

show abstract

“…In 1972 Harrison et al . 21 , based on their previous work on the use of the cream 23 , performed a study on both human and animals using Sulfamylon 5% Aqueous solution. No sepsis or mortality events were noted and the 5% aqueous solution was shown to be equivalent to that of the 11.2% cream.…”

Section: Discussionmentioning

confidence: 99%

“…Side effects included significant discomfort/pain, due to its high osmolality and hypertonicity, especially when applied to superficial burns 5,20 . Additional side effects were rash, formation of neo-eschar 2,21 , and acid-base imbalance (i.e. metabolic acidosis due to inhibition of carbonic anhydrase 22 ).…”

Section: Introductionmentioning

confidence: 99%

A Simple Cost-Saving Measure

Ibrahim

Fagan

Keaney³

et al. 2014

Journal of Burn Care & Research

View full text Add to dashboard Cite

Objective The optimal concentration of mafenide acetate solution for use in the treatment of burns is unknown. Despite data supporting the use of a 2.5% solution, 5% formulation is traditionally used, and has been the highest costing medication on formulary. The aim of the current study is to evaluate cost and patient outcomes associated with a new policy implementing the use of 2.5% solution in burn patients and restricting the 5% formulation to specific indications only. Methods A retrospective review of all patients receiving mafenide acetate solution at a single pediatric burn hospital was performed before and after the initiation of the new policy on the use of 5% versus 2.5% solution. Duration of therapy, adverse events, cost, incidence of wound infection and bacteremia were analysed. Results In 2009, 69 patients were treated with 5% mafenide acetate solution for a total cost of $125,000 ($1811/patient). In 2010, following the initiation of the policy, 48 patients were treated: 19 received 5% mafenide acetate solution with appropriate indication, while the remaining 29 received 2.5% solution for a total cost of $38,632 ($804/patient). There were no significant changes in the incidence of bacteremia or wound infection. No side effects of either solution were noted. Conclusions Under certain conditions, a 2.5% mafenide acetate solution appears sufficient. In this multinational pediatric burn hospital, the use of a 2.5% solution was not associated with increased bacteremia or wound infection and proved to be more cost-effective.

show abstract

The Absorption Into Burned Skin of Sulfamylon Acetate From 5 Per Cent Aqueous Solution

Cited by 22 publications

References 0 publications

Review of History of Basic Principles of Burn Wound Management

Review of History of Basic Principles of Burn Wound Management

the THE EFFECT OF CHITOSAN COATING ON MAFENIDE ACETATE-LOADED LIPOSOME CHARACTERIZATION AND DELIVERY THROUGH BURNED RAT SKIN

A Simple Cost-Saving Measure

Contact Info

Product

Resources

About