The absorption of tritium-labelled pyridoxine HCl in control subjects and in patients with intestinal malabsorption

Brain, M. C.; Booth, C. C.

doi:10.1136/gut.5.3.241

Cited by 30 publications

(2 citation statements)

References 9 publications

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“…Baker and Sobotka (1962) mentioned 'low circulating levels of vitamin B6' in this condition (non-tropical sprue). The tryptophan loading test may also be abnormal in this condition (Kowlessar, Haeffner, and Benson, 1964), and evidence of malabsorption of B6 has been reported by Brain and Booth (1964) using tritiated pyridoxine. In this study, 10 of the 12 (83%O) untreated patients with coeliac disease had subnormal pyridoxal levels, while four other patients who had been treated with a gluten-free diet all had normal levels.…”

Section: Control Subjectsmentioning

confidence: 83%

The measurement of serum pyridoxal by a microbiological assay usingLactobacillus casei

1970

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SYNOPSIS A new method has been developed for the assay of serum pyridoxal using L. casei. Bound pyridoxal phosphate in serum is converted by acid hydrolysis to pyridoxal for which this organism is specific. This method proved to be considerably more sensitive than other methods so far reported in the literature.Serum pyridoxal concentrations were measured in 151 control subjects aged 17 to 80 years. The range of concentrations found was 1l5 to 13'5 ng/ml which compared well with values obtained by most workers measuring pyridoxal phosphate by enzymatic methods. A marked fall with age was confirmed, and levels in women of childbearing age were lower than in men of comparable age. Subnormal serum pyridoxal concentrations were found in 62 % of patients with sideroblastic anaemia and in the majority of patients with rheumatoid arthritis, Crohn's disease, coeliac disease, and in pregnant women at term.

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Section: Control Subjectsmentioning

confidence: 83%

The measurement of serum pyridoxal by a microbiological assay usingLactobacillus casei

1970

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“…Obwohl in der L iteratu r [10,18,44,46] wiederholt au f Sym ptom e eines Mangels an wasserlöslichen Vitam inen bei der idiopathischen S teatorrhoe hingewiesen wird (H aut-und Schleim hautveränderungen, N euritiden), sind R esorptionsstörungen nur für die V itam ine B12 [15,59], Folsäure [9,15,32,59] und Pyridoxin [14,20,34] nachgewie sen. In U ntersuchungen an P atienten m it einheimischer und tropischer Sprue, bei denen die R esorption der V itam ine Bj, B2, B6, C und Fol säure geprüft wurde, fand sich lediglich eine verm inderte Folsäure resorption, w ährend alle übrigen V itam ine normal resorbiert w urden [26,50].…”

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Der Einfluss einer glutenfreien Diät auf die Nährstoffresorption bei der einheimischen Sprue

Kasper¹

1967

Digestion

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The B Vitamins and Vitamin C in Human Nutrition

Moran¹

1979

Am J Dis Child

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It was not until the 18th century that the importance of dietary factors in the genesis of diseases was recognized, nor until this century that the chemical structure of certain of these factors, termed "vitamins," was determined. These findings led to an understanding of the role of vitamins in intermediary metabolism that in turn fostered our present techniques for prevention and treatment of deficiency states. We are now discovering unusual disease states that can be treated with vitamins independent of the usual needs for adequate vitamin nutriture. Therefore, the interest in vitamins has recently shifted from prevention and treatment of deficiency states to their role as pharmacologic agents in the management of certain inborn errors of metabolism. The purpose of this article is to review the metabolism of B vitamins and vitamin C, their deficiency diseases, and their use in treatment of certain inborn errors in metabolism. GENERAL CONSIDERATIONS Role of Vitamins: Deficiency and 'Marginal' Deficiency The B group of vitamins include thiamine, riboflavin, niacin, vitamin BB, biotin, pantothenic acid, folate, and vitamin B,,. They are water solu¬ ble and act primarily as cofactors in biochemical reactions. With the excep¬ tion of vitamin B,,, they are not stored From the

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The absorption of tritium-labelled pyridoxine HCl in control subjects and in patients with intestinal malabsorption

Cited by 30 publications

References 9 publications

The measurement of serum pyridoxal by a microbiological assay usingLactobacillus casei

The measurement of serum pyridoxal by a microbiological assay usingLactobacillus casei

Der Einfluss einer glutenfreien Diät auf die Nährstoffresorption bei der einheimischen Sprue

The B Vitamins and Vitamin C in Human Nutrition

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