The Abundance and Function of Neutrophils in the Endometriosis Systemic and Pelvic Microenvironment

Abstract

Endometriosis is a common inflammatory illness in which endometrial tissue grows outside the uterine cavity. Immune dysfunction is now widely acknowledged as the primary cause of endometriosis. The immune cell population represented by neutrophils is thought to play an essential role in the etiology, pathophysiology, and associated clinical outcome. There is growing evidence that neutrophils have a role in chronic and aseptic inflammatory diseases, and endometriosis patients have increased levels of neutrophils in plasma, peritoneal fluid, and ectopic endometrium. Here, we sought to review the function of neutrophils in the pathogenesis of endometriosis, with an emphasis on the role of neutrophils in regulating endometrial angiogenesis and the local inflammatory microenvironment.

Enterotoxin‐related genes PPFIA4 and SCN3B promote colorectal cancer development and progression

“…[37,38] The genes included in their models were as follows: PTGER2, FGF2, IGFBP3, ANGPTL4, DKK1, WNT16, SPP1, ZNF532, COLEC12, DPP7/2, YWHAB, MCM4, FBXO46, GLP2R, VSTM2A, and so on. [37,39,40] In our model, we included directly nine key EIOGs, and finally got a mode with the highest AUC reached 0.788, which indicated that EIOS alone play an important role in the CRC progression. We also proposed that a better prognostic model could be established based on a comprehensive understanding all these genes.…”

Temporal Variations in Density and Distribution of Neutrophils with Associated Morphological Changes in Uterus at All Stages of Estrus Cycle in Mice

“…Absence of neutrophils/neutropenia impedes endometrial repair in mice [14]and also results in fetal abortions as they are critical for establishing utero-placental circulation [13]. Overinfiltration andactivation cause enhancement in the pathogenesis of endometriosis [15], cancer and auto immune diseases [7]. Therefore, for a better understanding of their regulation, role within the uterus, it is necessary to know their quantity, localization and distribution, during different stages of estrus cycle in physiological conditions [16].…”