The ac field patterns about living cells

Rivera, Hiram; Pollock, J. Kent; Pohl, Herbert A.

doi:10.1007/bf02788638

Cited by 12 publications

(6 citation statements)

References 4 publications

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“…Pohl, published several papers about the interactions of live cells with dispersed particles [13][14][15][16][17]. The main purpose of these studies was to verify the hypothesis suggested in late 1960s by H. Frohlich who had proposed that live cells emit an AC electric field [18,19].…”

Section: Long-range Interactions Of Microparticles With Live Cellsmentioning

confidence: 89%

“…Later, he and his group realized that all charges are screened in aqueous electrolyte solutions. The screening would make it practically impossible to generate a low-frequency electric field by moving charges inside the cell (see discussion on page 54 in [17]). In the later review [16], Pohl mentioned that frequencies were on a MHz scale.…”

Section: Micro-dielectrophoresismentioning

confidence: 99%

“…It simply recorded the patterns the particles formed near a particular cell in a small, suspended drop ( Fig. 1,a from reference [17]). We selected this particular photo because it provides evidence that the observed interaction is much longer in range than one assumes.…”

Section: Long-range Interactions Of Microparticles With Live Cellsmentioning

confidence: 99%

“…Pohl and his group at the Massachusetts Institute of Technology (MIT) [13][14][15][16][17]. They monitored the motion of small particles in the vicinity of biological cells to verify Frohlich's hypothesis [18,19] that implied that biological cells generated an AC electric field.…”

Section: Introductionmentioning

confidence: 99%

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Peculiarities of live cells' interaction with micro- and nanoparticles

Dukhin¹,

Ulberg²,

Карамушка³

et al. 2010

Advances in Colloid and Interface Science

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Section: Long-range Interactions Of Microparticles With Live Cellsmentioning

confidence: 89%

Section: Micro-dielectrophoresismentioning

confidence: 99%

Section: Long-range Interactions Of Microparticles With Live Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peculiarities of live cells' interaction with micro- and nanoparticles

Dukhin¹,

Ulberg²,

Карамушка³

et al. 2010

Advances in Colloid and Interface Science

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“…Magnetic fields have the ability to extend over macroscopic distances, but lack the selective potential of the beacons of Banerjee et al (3). There is a growing awareness of the role of electromagnetic waves in living matter, how these affect cell function and are expressed in vivo (13,14), but mostly in the context of signaling rather than as a motive force.…”

mentioning

confidence: 99%

Steering colloidal particles over millimeter distances with soluto-inertial beacons

Zwanikken

2016

Proc. Natl. Acad. Sci. U.S.A.

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The last decades have seen the impressive rise of nanotechnology and nanomedicine, and the concomitant integration of nanometer-sized agents (1) and laboratory-on-a-chip devices (2). The imagination can hardly keep up with the variety of nanoparticles that are currently synthesized by scalable technologies, not to speak of the sheer inexhaustible range of properties that can be imparted by grafting complex molecules to their surface. These developments have revolutionized materials design and enabled the formulation of sophisticated therapeutics. There is, however, a limit to the range over which these particles can be steered in solution, and many applications rely on thermal processes that restrict control or reaction speed for the intended purpose, whether it is the formation of a large defect-free crystal or the adsorption of a diluted component to a template. Gravity and centrifugation can induce deposition, but are not very specific in their effect and direction. Electric fields offer more tunability, but have a limited range in aqueous solutions. Mother Nature clearly found a wealth of solutions to operate beyond the micrometer-length scale, to communicate over large distances, and speed-up rare events, and one might wonder if there are simple principles that could be adopted in an artificial setting. In PNAS, Banerjee et al. (3) demonstrate an interaction that extends over hundreds of micrometers, lasts for several minutes, and is highly specific to the type of dissolved particle. The principle relies on a mediating solute that is emitted by a socalled beacon. The beacon creates a gradient in solute concentration that induces polystyrene particles and decane droplets to move in opposite directions.It is tempting to make comparisons with chemotaxis, the ability of bacteria to move toward higher concentrations of nutrients or lower concentrations of toxins. However, the colloidal particles in the experiments by Banerjee et al. (3) migrate without any activated process, and are purely driven by a wellcontrolled thermal process known as diffusiophoresis. The velocity of the colloids depends on their surface properties, which determine the interaction with the solute. An attraction between solute and colloids drives the colloids up the solute concentration gradient and a repulsion down gradient, as if the colloids had a certain sense of smell.To demonstrate the physical process itself, Banerjee et al. (3) create a three-channel device, in which the outer channels act as a solute reservoir that maintains a stable solute gradient over the inner channel, containing colloidal particles. Banerjee et al. choose the surfactant SDS as the solute, and use either fluorescent sulphonated polystyrene colloids or decane drops as colloidal particles. Polystyrene colloids clearly migrate down SDS concentration gradients, whereas decane drops migrate up the gradient, over about 100 μm in 100 s (Fig. 1A). Banerjee et al. mention that concentration gradients arise spontaneously around membranes, reactive surfaces, electrodes, ...

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