The Acceptance of the Collagen Sponge Diaphragm as an Intravaginal Contraceptive in Human Volunteers

Theoretical as well as practical-clinical applications of one form of collagen (collagen sponge) as a biodegradable material is reviewed. The role of porosity of the sponge and surface characteristics of the meshwork in relation to cell ingrowth are considered essential features of collagen sponge. Rate of resorption and antigenicity could be controlled by graded crosslinking of collagenous framework. Four basic examples of clinical use of collagen sponge are presented: as wound (burn) dressing material, as a matrix, for bone and cartilage repair, as an intravaginal contraceptive diaphragm, and as surgical tampons.

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Collagen sponge: Theory and practice of medical applications

Chvapil

1977

J. Biomed. Mater. Res.

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213

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Reaction of vaginal tissue of rabbits to inserted sponges made of various materials

Chvapil

Owen

et al. 1979

J. Biomed. Mater. Res.

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Sponges of the same size made of collagen (CS), polyurethane (PU), polyvinylalcohol (PVA) and acetylcellulose (AC) were inserted for 10 days in the vaginas of 22 rabbits. Light and scanning electron microscopy of the vaginal wall and its mucosal lining showed signs of cytotoxicity only with PU and AC while CS and PVA picture did not differ from sham controls. In order to explain the reasons for the toxic effects, all sponges were extracted into aqueous or organic solvent media and analyzed by gas liquid chromatography. Only several minute peaks in organic solvents were found. Extracts of all sponges tested for cytotoxicity in fibroblast cultures showed significant inhibition of H3-thymidine uptake. Nevertheless, extract of collagen sponge was significantly less cytotoxic than the extracts of all other sponges.

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Studies on vaginal malodor

Chvapil

Eskelson

1978

Arch. Gynak.

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The Acceptance of the Collagen Sponge Diaphragm as an Intravaginal Contraceptive in Human Volunteers

Cited by 9 publications

References 8 publications

Collagen sponge: Theory and practice of medical applications

Collagen sponge: Theory and practice of medical applications

Reaction of vaginal tissue of rabbits to inserted sponges made of various materials

Studies on vaginal malodor

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