The Accumulation and Metabolism Characteristics of Rare Earth Elements in Sprague–Dawley Rats

Cao, Bing; Wu, Jing; Xu, Chang‐Lian; Chen, Yan; Xie, Qing; Ouyang, Li; Wang, Jingyu

doi:10.3390/ijerph17041399

Cited by 24 publications

(7 citation statements)

References 26 publications

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“…To date, only a small number of studies in the literature have analyzed the doseresponse relationships between REE exposure and their concentrations in biological matrices in rats. A previous study found that the concentrations of five REEs (La, Ce, Pr, Nd, and Gd) in rat fur were positively correlated with their administration dose [24], whereas no such correlation was found in whole blood, which is consistent with our findings. However, our study provides additional confirmation of the utility of up to 14 REEs as biomarkers.…”

Section: Discussionsupporting

confidence: 92%

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Pang

Jiang

et al. 2021

IJERPH

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Solid fuel combustion is an important source of the release of rare earth elements (REEs) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs. We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model.

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Section: Discussionsupporting

confidence: 92%

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Pang

Jiang

et al. 2021

IJERPH

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“…Fang et al (2018) found a significant effect on body weight and feed intake at 6 times higher concentration, or 60 mg La per kg body weight. However, Cao et al (2020) found no effect after a shorter 28-day exposure to 129 mg/kg body weight by gavage but a clear effect at the ten-fold concentration. This shorter exposure should be less representative of continuous exposures than the 90-day exposures of Fang et al (2018).…”

Section: A324 Mammalsmentioning

confidence: 76%

“…Scarce evidence suggests that a large fraction is lost from 5 to 8 weeks after ingestion for rats (Cao et al, 2020). A general retention time of 45 days was given by Nakamura, Tsumura, Tonogai, Shibata, and Ito (1997).…”

mentioning

confidence: 99%

Hypothetical Soil Thresholds for Biological Effects of Rare Earth Elements

Bengtsson¹

2021

JAS

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Objectives: Anthropogenic exposures to rare earth elements are poorly known and there is limited information on their toxicity and ecotoxicity. At the same time, world production of rare earth elements has doubled every 15 years over the last half-century, and high environmental concentrations of gadolinium and lanthanum have already been found. The current review aims to give some estimates of overall exposures and an initial in-depth appraisal of thresholds for effects on agricultural soil. The results are envisaged to be used in initial assessments of agricultural soil where the natural concentrations have been anthropogenically enhanced. Methods: An extensive review has been made of available scientific literature. Criteria have been established for the selection and analysis of eligible research. For instance, only effects on soils with vegetation have been included in the assessment of biological effects. A species sensitivity distribution based on 25% inhibition of organism functions has been used to establish thresholds for effects on soil organisms. Results: Around the year 2000, mean anthropogenic contributions of lanthanides in European soil regions were at most a few per cent of the total soil content. Since then, they should have increased considerably. The proposed hypothetical threshold for agricultural soils is 1125 mg total rare earth element per kg of soil. This threshold is about 8 times the natural soil concentration. Conclusions: If this result holds up to scrutiny, it implies that general anthropogenic pollution by rare earth elements will not be a threat to agricultural sustainability for the coming generation. A preliminary assessment suggests that this threshold would also protect humans from adverse effects due to secondary exposure.

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“…REEs are commonly used in agriculture as forage additives and fertilizers and are consumed via the food chain. Approximately 90% of the global REEs are distributed in China, indicating more absorption hazards for the Chinese population ( 9 ). Although few studies focus on REEs, several studies still prompt that they might influence cancer.…”

Section: Introductionmentioning

confidence: 99%

The role of rare earth elements and dietary intake in tongue cancer: a mediation analysis in southeast China

Wang

Liu

Chen

et al. 2023

Front. Public Health

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ObjectiveThe current research aimed to examine how dietary intake and rare earth elements may affect the development of tongue cancer.MethodsThe serum levels of 10 rare earth elements (REEs) in 171 cases and 171 healthy matched controls were measured by inductively coupled plasma mass spectrometry (ICP-MS). The conditional logistic regression was used to examine the relationship between dietary intake, serum levels of 10 REEs, and tongue cancer. Mediation effect and multiplicative interaction analysis were then performed to estimate the potential contribution of REEs in dietary intake associated with tongue cancer.ResultsCompared with the control group, patients with tongue cancer consumed significantly less fish, seafood, fruit, green leafy vegetables, and non-green leafy vegetables, with higher serum praseodymium (Pr), dysprosium (Dy), and lanthanum (La) levels, and lower serum cerium (Ce) and scandium (Sc) levels. The interaction effect was observed between some REEs and food categories. Green vegetables' impact on the risk of tongue cancer is partially attributed to the La and Thorium (Th) elements (P < 0.05, the mediated proportion were 14.933% and 25.280%, respectively). The effect of non-green leafy vegetables for tongue cancer mediated via Pr, Dy, and Th (P < 0.05, the mediated proportion were 0.408%, 12.010%, and 8.969%, respectively), and the Sc components in seafood (P < 0.05, the mediated proportion was 26.120%) is partly responsible for their influence on the risk of tongue cancer.ConclusionThe correlation between REEs and dietary intakes for tongue cancer is compact but intricate. Some REEs interact with food intake to influence tongue cancer, while others act as a mediator.

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The Accumulation and Metabolism Characteristics of Rare Earth Elements in Sprague–Dawley Rats

Cited by 24 publications

References 26 publications

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Hypothetical Soil Thresholds for Biological Effects of Rare Earth Elements

The role of rare earth elements and dietary intake in tongue cancer: a mediation analysis in southeast China

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