The accumulation, distribution, and toxicological effects of dietary arsenic exposure in lake whitefish (Coregonus clupeaformis) and lake trout (Salvelinus namaycush)

Pedlar, R.M; Ptashynski, M.D; Wautier, Kerry; Evans, R. E.; Baron, Christopher L.; Klaverkamp, J. F.

doi:10.1016/s1532-0456(01)00281-2

Cited by 38 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pedlar and Klaverkamp (2002) found that lake whitefish fed a diet of 100 μg/g arsenic containing food for 30 days accumulated arsenic in the pyloric caeca> liver>intestine≫stomach (muscle was not analyzed). In lake whitefish and lake trout (Salvelinus namaycush) also fed diets containing arsenic, the highest concentrations of arsenic were found in the pyloric caeca and liver, and lower concentrations in the muscle (Pedlar et al 2002b). Higher concentrations of total arsenic in the liver compared to muscle have also been shown to occur in fish living in arsenic-contaminated freshwater ecosystems (Jankong et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Arsenic concentration and speciation in five freshwater fish species from Back Bay near Yellowknife, NT, CANADA

Rosemond

Xie

Liber

2008

Environ Monit Assess

View full text Add to dashboard Cite

The concentration of total arsenic and five different arsenic species [As(III), As(V), monomethylarsonic acid (MMA), dimethylarsenic acid (DMA), and arsenobetaine (AsB)], were measured in the muscle, liver and gastrointestinal tract (GIT) of five different fish species [lake whitefish (Coregonus clupeaformis), walleye (Stizostedion vitreum), northern pike (Esox lucius), white sucker (Catostomus commersoni) and longnose sucker (Catostomus catostomus)] from Back Bay, Great Slave Lake, near the city of Yellowknife, NT, Canada. The total concentration (dry weight) of arsenic in muscle ranged from 0.57 to 1.15 mg/kg, in the liver from 0.42 to 2.52 mg/kg and in the GIT from 1.48 to 8.92 mg/kg. Among fish species, C. commersoni had significantly higher total arsenic concentrations in the GIT than S. vitreum, E. lucius and C. clupeaformis, and higher total arsenic concentrations in the liver than C. clupeaformis. The mean concentration of As(III) and As(V) in the muscle of all fish ranged from < or =0.01 to 0.05 mg/kg and < or =0.01 to 0.02 mg/kg, respectively, and together comprised < or =7.5% of the total arsenic measured in muscle. The concentrations of MMA were below detection in the muscle of all five fish species. However, AsB and DMA were measured in all fish species and nearly all fish tissues. The concentrations of AsB ranged from 0.01 to 0.13 mg/kg and the concentrations of DMA ranged from <0.02 to 0.45 mg/kg. The majority (>50%) of organic arsenic in almost all of the tissues from fish caught in Back Bay was not directly identified. Evidence from the literature suggests that most of these other organic arsenic species were likely trimethylated arsenic compounds, however, further analytical work would need to be performed to verify this hypothesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Arsenic concentration and speciation in five freshwater fish species from Back Bay near Yellowknife, NT, CANADA

Rosemond

Xie

Liber

2008

Environ Monit Assess

View full text Add to dashboard Cite

show abstract

“…The phenomenon was explained in terms of preference of metallothioneins binding with metals (Asselman et al, 2012). It has also been reported that the dietary arsenic exposure had no significant effect on hepatic and renal metallothionein in lake white fish (Coregonus clupeaformis) and lake trout (Salvelinus namaycush) (Pedlar et al, 2002). Studies with dogfish (Scyliorhinus canicula) revealed that except for copper, exposure to other metals like nickel, cadmium, lead, and silver could not induce metallothionein in gill and liver of fish (de Boeck et al, 2010).…”

Section: Tablementioning

confidence: 98%

Metallothionein, oxidative stress and trace metals in gills and liver of demersal and pelagic fish species from Kuwaits’ marine area

Beg

Al-Jandal

Al-Subiai

et al. 2015

Marine Pollution Bulletin

View full text Add to dashboard Cite

“…The freshwater fingerlings, Labeo rohita (length 6 ± 1 cm and weight 8 ± 1 g) were procured from the Government fish farm at Lalpet, 15 km away from the Annamalai University, India. The collected fish were acclimated to laboratory condition for 15 days (Pedlar et al, 2002). For the entire duration of the experiment, the fish were fed with commercial fish feed (Himalaya company, India), which had no detectable amount of arsenic content.…”

Section: Methodsmentioning

confidence: 99%

A study of the subchronic effects of arsenic exposure on the liver tissues of Labeo rohita using Fourier transform infrared technique

Palaniappan

Vijayasundaram

Prabu

2011

Environmental Toxicology

View full text Add to dashboard Cite

In this work, an attempt has been made to study the subchronic effects of arsenic exposure on the biochemical composition; mainly proteins of the liver tissues of Labeo rohita fingerlings by using Fourier transform infrared (FT-IR) spectroscopic technique. The study was carried out using a Perkin Elmer-Spectrum Rx1 spectrometer. Because of arsenic exposure, significant reductions in the intensity as well as area of amide bands have been observed in the liver tissues. The decreased intensity of the amide bands could be interpreted as the result of alteration of the protein synthesis due to the high affinity of metal compounds towards different amino acid residues of proteins. Further, meso-2, 3-dimercaptosuccinic acid (DMSA) treatment shows the recovery of the protein content in the liver tissues. To confirm that the changes observed are only due to the bio-accumulation of arsenic, the concentration of arsenic in the liver tissues of Labeo rohita was determined by using Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES). It is observed that the arsenic level in the control tissues is found to be below detectable limit, whereas the arsenic exposed liver shows an accumulation of 66.68 ± 0.43 μg/g and DMSA treatment reduces the arsenic content to 17.96 ± 0.19 μg/g. In conclusion, this study gives clear evidence that the use of FT-IR spectroscopy is a powerful approach to achieve more insight into the protein alterations caused by arsenic.

show abstract

The accumulation, distribution, and toxicological effects of dietary arsenic exposure in lake whitefish (Coregonus clupeaformis) and lake trout (Salvelinus namaycush)

Cited by 38 publications

References 39 publications

Arsenic concentration and speciation in five freshwater fish species from Back Bay near Yellowknife, NT, CANADA

Arsenic concentration and speciation in five freshwater fish species from Back Bay near Yellowknife, NT, CANADA

Metallothionein, oxidative stress and trace metals in gills and liver of demersal and pelagic fish species from Kuwaits’ marine area

A study of the subchronic effects of arsenic exposure on the liver tissues of Labeo rohita using Fourier transform infrared technique

Contact Info

Product

Resources

About