The Accumulation of Mono‐2‐Ethylhexylphthalate (MEHP) During Storage of Whole Blood and Plasma

Rock, G.; Secours, V. E.; Franklin, Claire A.; Chu, In-Sun; Villeneuve, D. C.

doi:10.1046/j.1537-2995.1978.18579036383.x

Cited by 93 publications

(48 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DEHP is mechanically trapped in the vinyl matrix and is insoluble in water, but it will leach into hydrophobic materials such as plasma lipoproteins or cell membranes. The acute toxicity of DEHP is very low, but it does bind to red cells, platelets, and plasma during blood storage, and is converted into the monoester MEHP (Rock et aL 1978). There has been a long-standing concern that DEHP may have toxic effects.…”

Section: Concern Over Phthalate Toxicitymentioning

confidence: 99%

Long-Term Storage and Preservation of Red Blood Cells

Moore¹

1991

Biotechnology of Blood

View full text Add to dashboard Cite

Section: Concern Over Phthalate Toxicitymentioning

confidence: 99%

Long-Term Storage and Preservation of Red Blood Cells

Moore¹

1991

Biotechnology of Blood

View full text Add to dashboard Cite

“…The hydrolysis of DEHP to MEHP is catalyzed by pancreatic lipase (9) as well as by esterases of serum (12), mucosal epitherium (10,11) and liver (6). The data from the present study on DEHP hydrolysis indicate that the hydrolytic activities of the fetuses up to the 9th day of gestation were almost negligible compared with those of the pancreas and liver.…”

Section: Discussionmentioning

confidence: 99%

“…DEHP is known to be hydrolyzed to MEHP and 2-ethylhexanol (6-8). The hydrolysis is catalyzed by pancreatic lipase (9), acid and alkaline esterases in intestinal mucosa (10,11), plasma (12), and liver (6). Tissue distribution of MEHP after the oral administration of DEHP (or MEHP) has been reported by several investigators in pregnant or nonpregnant rats (7,13,14).…”

Section: Introductionmentioning

confidence: 99%

Fetotoxic Effects of Mono-2-Ethylhexyl Phthalate (MEHP) in Mice

Tomita¹,

Nakamura²,

Yagi³

et al. 1986

Environmental Health Perspectives

View full text Add to dashboard Cite

Mono(2-ethylhexyl) phthalate (MEHP), one of the main metabolites of di(2-ethylhexyl) phthalate (DEHP), exerted embryo/fetotoxic effects similar to those of DEHP at lower doses. Oral administration of MEHP (1 mL/kg) to the mice of 8 days gestation resulted in less than 32% of live fetuses, all of which were deformed.When DEHP (10 mL/kg) was given to the pregnant mice of 8 days gestation, approximately 0.03% and 0.003% of the administered dose was found in fetuses as DEHP and MEHP, respectively, after 12 hr.The presence of the MEHP in fetuses is probably due to the transplacental crossing of the MEHP formed in the maternal body, since the fetuses of mice up to day 9 of pregnancy showed no hydrolytic activity of DEHP to MEHP. Crossing of MEHP through the placenta was proven by an experiment in which MEHP was administered in pregnant mice.A single injection of MEHP (25 or 50 mg/kg), but not DEHP (500 mg/kg) into pregnant mice, induced a significantly high incidence of somatic mutations in the coat hair of offspring of mice (KYG, 9 x PW, d; C57BL/6Crj, 9 x PW, 6). All these data suggest that MEHP could be responsible for the embryotoxic/ fetotoxic effects observed with DEHP.

show abstract

“…The conversion has been shown to increase with increasing storage time and temperature, while storage at low temperatures prevent it (Cole et al 1981, Inoue 2005, Rock et al 1978. MEHP has been measured in stored blood, blood products and peritoneal dialysate (Cole et al 1981, Labow et al 1986, Peck et al 1979, Rock et al 1978, Sjoberg et al 1985a, Sjoberg et al 1985b). Nevertheless, the data available are not sufficient to accurately calculate the in vitro conversion rates (Health Canada 2002).…”

Section: Adult Exposure During Medical Proceduresmentioning

confidence: 99%

Plasticizer concentration in cord blood cryopreserved with DMSO

Yamaguchi

Takanashi

Ito

et al. 2013

Bone Marrow Transplant

View full text Add to dashboard Cite

The Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) has evaluated the exposure to DEHP for the general population and patients during medical procedures. In many cases the exposure is significant and exceeds the toxic doses observed in animal studies. There is limited evidence indicating a relation between DEHP exposures and certain effects in humans. However, it is recognised that especially the potentially high exposure during medical treatments raise a concern, even in the absence of clinical or epidemiological evidence, for harmful effects in humans. For certain uses of DEHP alternative plasticizers for PVC are available. The Committee got access to toxicity data for eight possible alternative plasticizers and compared their toxicity with that of DEHP. In respect to reproductive toxicity in animal studies DEHP induces more severe effects compared with some of the alternatives. A risk assessment of these available alternative plasticizers could not be performed due to a lack of exposure data from medical devices. Each alternative to DEHP, however, must also be evaluated with regard to their functionality in respect to medical devices. The risk and benefits of using alternative plasticizers should be evaluated case by case.

show abstract

The Accumulation of Mono‐2‐Ethylhexylphthalate (MEHP) During Storage of Whole Blood and Plasma

Cited by 93 publications

References 11 publications

Long-Term Storage and Preservation of Red Blood Cells

Long-Term Storage and Preservation of Red Blood Cells

Fetotoxic Effects of Mono-2-Ethylhexyl Phthalate (MEHP) in Mice

Plasticizer concentration in cord blood cryopreserved with DMSO

Contact Info

Product

Resources

About