The Accuracy of Colposcopic Grading for Detection of High-Grade Cervical Intraepithelial Neoplasia

Massad, L. Stewart; Jerónimo, José; Katki, Hormuzd A.; Schiffman, Mark

doi:10.1097/lgt.0b013e31819308d4

Cited by 132 publications

(103 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 In the study by Gupta et al also correlation between colposcopic findings and HPE results was seen in 90 (88.23%) patients which is also comparable with our study. 8 Meenakshi et al found 96% correlation between colposcopy and histology.…”

supporting

confidence: 81%

Colposcopic evaluation of cervical erosion in symptomatic women

Patil

Sharma²

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: This study was carried out to find the colposcopic findings in the symptomatic patients with cervical erosion and correlate the findings with cytology and histopathology.Methods: All the patients coming to gynaecological OPD with symptoms of white discharge, pruritus vulvae, menstrual irregularities were examined by per speculum examination and all those who had cervical erosion were included in the study and pap smear and colposcopy both were done in all subjects. The colposcopic guided biopsy was done in women with abnormal findings on colposcopy (50 women) and reports were compared. Abnormal colposcopic findings were graded according to Reid’s colposcopic index (RCI).Results: Majority of patients came with the complaint of white discharge per vaginum (55%).Out of 120 patients, 85 women (70.9%) had inflammatory pap smear and 35 women (29.1%)had abnormal pap smear. All patients underwent colposcopic examination and out of 120 patients, 67(55.8%) showed normal colposcopic findings and 50 women (41.6%) had abnormal colposcopic finding and biopsy was taken. 3 women had unsatisfactory colposcopy. Histopathology confirmed 24 (48%) women with CIN I and 12 (24%) CIN II and 6 (12%) CIN III and 2 (4%) women with carcinoma cervix. The colposcopy findings and histopathology correlated in 88%.Conclusions: Colposcopy should be prescribed to all symptomatic patients with cervical erosion as it is a good diagnostic tool for pre-malignant conditions of cervix and correlates well with histopathological findings.

show abstract

supporting

confidence: 81%

Colposcopic evaluation of cervical erosion in symptomatic women

Patil

Sharma²

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Colposcopy impressions are subjective; according to degree of white epithelium, contour of surfaces, margins, and vascular patterns. In cases of CIN 2-3, colposcopy missed to diagnose at the rate of underestimation was 57%, and the overestimation rate by Reid Index scoring was 70% (Massad et al, 2009;Stoler et al, 2011). Recent systematic review and meta-analysis stated that colposcopic biopsies yielded a sensitivity of 81.4% and specificity of 63.3% for CIN2-3 detection (Underwood et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Importance of Women with Squamous Cell Carcinoma Cytology on Siriraj Liquid-Based Cervical Cytology

Ruengkhachorn

Laiwejpithaya²,

Leelaphatanadit³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Objectives: The purposes of this study were to determine the prevalence and predictive value to detect significant neoplasia and invasive lesions, and to evaluate the correlation between clinical and histopathology of women with squamous cell carcinoma (SCCA) on Siriraj liquid-based cervical cytology (Siriraj-LBC). Methods: The computerized database of women who underwent Siriraj-LBC at Siriraj Hospital, Mahidol University from January 2007 to December 2010 were retrieved. The hospital records of women with SCCA cytology were reviewed. Results: The prevalence of SCCA cytology was 0.07%. A total of 86 women, mean age was 58.1 years. Sixty-one women (70.9%) were post-menopausal. Overall significant pathology and invasive gynecologic cancer were detected in 84 women (97.7%) and 71 women (82.5%), respectively. The positive predictive values for detection of significant neoplasia and invasive lesion were 97.7% and 82.6%, respectively. The cervical cancer was diagnosed in 69 women and among these 58 women were SCCA. Thirteen women (15.1%) had cervical intraepithelial neoplasia (CIN) 3 and two women (2.3%) had cervicitis. The sensitivity and specificity of colposcopy for cervical cancer detection in SCCA cytology were 83.3% and 75%, respectively. Median follow up period was 17.6 months and 64 patients were alive without cytologic abnormality. Conclusions: The final histopathology of SCCA cytology in our populations demonstrated a wide variety, from cervicitis to invasive cancer and the most common diagnosis was invasive cervical cancer. Colposcopy with biopsy and/or endocervical curettage and loop electrosurgical excision procedure should be undertaken to achieve histologic diagnosis.

show abstract

“…In the same study, the sensitivity of colposcopy at low thresholds was high (74.5%), but the specificity was lower at 57.5%. 10 The performance and accuracy of colposcopy depends largely on the training, experience, and skills of the colposcopist. Hence, sensitivity and specificity of colposcopy varies widely among studies in different parts of the world.…”

Section: -6mentioning

confidence: 99%

A study of cytology and colposcopy in VIA (visual inspection of cervix with 5% acetic acid) positive women

Arora

Patel

Poddar

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

INTRODUCTIONGlobally, in the year 2008, there were an estimated 12.7 million new cancer cases and 7.6 million cancer deaths. 1Cervical cancer is the third most common cancer among women worldwide, with an estimated 529 000 new cases and 275 000 deaths in 2008. More than 85% of the global burden of cervical cancer cases and 88% of cervical cancer deaths occur in developing countries.1 Cervical cancer is the most common cancer among Indian women and was estimated to have been responsible for 134 420 new cases and 72 825 deaths in the year 2008.1 India contributes to 25.4% and 26.5% of the global burden of cervical cancer cases and mortality, respectively. The age-standardized incidence rate and age-standardized mortality rate of cervical cancers are 27.0 and 15.2, respectively, among Indian women. Cervical cancer is responsible for 25.9% of all cancer cases and 23.3% of all cancer deaths among Indian women.1 The incidence of cervical cancer is 1.5 to 2 times higher in rural area women than urban area. Cervical cancer is preventable in pre-invasive state when effective programmes are ABSTRACT Background: Cervical cancer is the most common cancer among Indian women. Cervical cancer is preventable in pre-invasive state when effective programmes are implemented to detect and treat its precursor lesions. "Single Visit" screen and treat strategy that uses VIA and colposcopy alone that eliminates the need for repeated visits due to delays in diagnostic results, will be highly attractive in terms of cost effectiveness and compliance to treatment, which is crucial to bring down the incidence and mortality due to cervical cancer. The present study evaluates the performance of colposcopy vs conventional cytology in estimating the presence and grade of cervical disease against the reference standard of histopathology as a secondary test modality to triage women found positive on primary screening by visual inspection with 5% acetic acid (VIA). Methods: This is a retrospective study carried out on 50 women aged between 18-50 years who tested positive on VIA between August 2013 to November 2015. Data were entered in the institution using standard computer software [EPIINFO software]. Diagnostic accuracy for single test was calculated using 2*2 tables and standard formulae. Results: The diagnostic accuracy of Pap smear was found to be 77% and that of Colposcopy was 87%. The accuracy of colposcopy was higher than that of Pap smear. Conclusions: Invasive cervical cancer is preceded by pre-invasive disease in most women. There is a lag time of 10-20 years before the disease progresses from pre-invasive to invasive disease. Prevention of invasive cancer is by screening, diagnosis and treatment of pre-invasive diseases. Thus, early diagnosis of CIN (cervical intraepithelial neoplasia) in adult women is a desirable goal.

show abstract

The Accuracy of Colposcopic Grading for Detection of High-Grade Cervical Intraepithelial Neoplasia

Cited by 132 publications

References 25 publications

Colposcopic evaluation of cervical erosion in symptomatic women

Colposcopic evaluation of cervical erosion in symptomatic women

Clinicopathologic Importance of Women with Squamous Cell Carcinoma Cytology on Siriraj Liquid-Based Cervical Cytology

A study of cytology and colposcopy in VIA (visual inspection of cervix with 5% acetic acid) positive women

Contact Info

Product

Resources

About