Objective To examine the ability of the criteria proposed by the WHO to identify pneumonia among cases presenting with wheezing and the extent to which adding fever to the criteria alters their performance. Design Prospective classifi cation of 390 children aged 2-59 months with lower respiratory tract disease into fi ve diagnostic categories, including pneumonia. WHO criteria for the identifi cation of pneumonia and a set of such criteria modifi ed by adding fever were compared with radiographically diagnosed pneumonia as the gold standard. Results The sensitivity of the WHO criteria was 94% for children aged <24 months and 62% for those aged ≥24 months. The corresponding specifi cities were 20% and 16%. Adding fever to the WHO criteria improved specifi city substantially ( to 44% and 50%, respectively). The specifi city of the WHO criteria was poor for children with wheezing (12%). Adding fever improved this substantially ( to 42%). The addition of fever to the criteria apparently reduced their sensitivity only marginally (to 92% and 57%, respectively, in the two age groups). Conclusion The authors' results reaffi rm that the current WHO criteria can detect pneumonia with high sensitivity, particularly among younger children. They present evidence that the ability of these criteria to distinguish between children with pneumonia and those with wheezing diseases might be greatly enhanced by the addition of fever.Pneumonia is still a leading disease in childhood in developing countries. 1 2 The WHO has developed guidelines, based on simple clinical signs, for the identifi cation and treatment of pneumonia in developing countries. 3 4 Despite widespread recognition that the WHO case management strategy has helped to reduce mortality, 5 there is concern that children with non-severe pneumonia are still receiving antibiotics unnecessarily. Studies have reported a lot of antibiotic treatment failure for pneumonia in children with wheeze, 6 7 suggesting they constitute a special group requiring a separate management algorithm. 7 8 We examined the ability of the WHO criteria to identify pneumonia among cases presenting with wheezing and how adding fever to these criteria altered their performance.
PATIENTS AND METHODSWe analysed data from a prospective study on children living in São Paulo, Brazil. Details of the clinical data have already been published. 9
Study population and diagnostic defi nitionsChildren aged between 2 and 59 months presenting to the paediatric emergency departments of fi ve public hospitals in a 15-month period were screened by a paediatrician upon arrival. Children with acute lower respiratory tract disease (LRTD) (wheezing, rales, tachypnoea, and/or dyspnoea were considered to be signs of LRTD) whose parents gave informed consent, were recruited into the study, excluding those with: recent history of aspiration (liquid or foreign body); tuberculosis; measles; pertussis; congenital, inherited, neurological, neuromuscular or immunological diseases; cancer; or gastrooesophageal refl ux...