The accuracy of renal tumor biopsy: analysis from a national prospective study

Bernhard, Jean-Christophe; Bigot, Pierre; Pignot, G.; Zini, Luca; Lang, Hervé; Crépel, Maxime; Monod, P; Salomon, Laurent; Bellec, L.; Rouprêt, Morgan; Schneider, Meike; Xylinas, Évanguelos; Paparel, P.; Bruyère, F.; Berger, J.; Ansieau, J.P.; Gimel, P.; Salomé, F.; Castagnola, C.; Pfister, Christian; Legraverend, J. M.; Timsit, Marc‐Olivier; Pellec, L. Le; Auberget, J. L.; Rolland, E.; Mallet, R.; Méjean, A.; Patard, Jean Jacques

doi:10.1007/s00345-014-1432-0

Cited by 19 publications

(20 citation statements)

References 25 publications

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“…16,17 The exception, a mis-diagnosed neuroblastoma in one case, was due to difficulties of typing small tumors of infancy. 3,8,17 Although it has been stressed that the main indication for FNAC in the diagnose of pediatric tumors is to rule out malignancy. 3,8 We feel that every effort should be made to differentiate Wilm's tumor from neuroblastoma, whenever the available material permits, immunohistochemistry and or electron microscopy can be employed on pediatric small cell tumors to solve this problem.…”

Section: Discussionmentioning

confidence: 99%

“…3,8,17 Although it has been stressed that the main indication for FNAC in the diagnose of pediatric tumors is to rule out malignancy. 3,8 We feel that every effort should be made to differentiate Wilm's tumor from neuroblastoma, whenever the available material permits, immunohistochemistry and or electron microscopy can be employed on pediatric small cell tumors to solve this problem. 3,4,8 Regarding the specificity of our series, no evidence of false positive diagnostic case using FNAC was un counted (specificity 100%).…”

Section: Discussionmentioning

confidence: 99%

“…The main problem of false negative result in the present and other series is mainly due to mis-shitting the target of the renal mass by needle puncture, insufficient sample and or auspicious aspirate due to poorly preserved cell and or extensive haemorrhagic bloody sample or associated necrosis. 1,5,7,8 Recent technologic advances in the diagnostic radiology and increased experience of the clinician permit in many cases the anticipation of a correct diagnoses of an actual renal tumors without morphological confirmation. 7,[12][13][14] Based on our experience gained from the present study and reviewing of other, the following diagnostic procedure in suspected renal masses is presumed to provide a very high diagnostic accuracy with a minimum risk and inconvenience to the patient.…”

Section: Discussionmentioning

confidence: 99%

“…3,8 We feel that every effort should be made to differentiate Wilm's tumor from neuroblastoma, whenever the available material permits, immunohistochemistry and or electron microscopy can be employed on pediatric small cell tumors to solve this problem. 3,4,8 Regarding the specificity of our series, no evidence of false positive diagnostic case using FNAC was un counted (specificity 100%). The sensitivity ranged from 75% to 100%, specificity 81% to 100% over all accuracy ranged 80% to 100%.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] If ultrasonic scanning and iv pyelography OS ultrasonic scanning alone demonstrate amass, this is punctured under the guidance of ultrasound. 13,14 If tumor cells are demonstrated in the aspirate, further investigation can be omitted.…”

Section: Discussionmentioning

confidence: 99%

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The role of ultrasonic guided fine needle aspiration cytology in the diagnoses of renal masses

2017

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Background: FNAC has been widely applied in the diagnosis of tumors and tumor like lesion of the abdomen including the kidney. The aim of this study was to evaluate the outcome of FNAC to a sample of Iraqi patients with kidney tumor.Methods: Patients with clinical, radiological suspicion of renal masses underwent FNAC of the kidney under ultrasound guidance were invited to this study. Those who fulfilled inclusion criteria were recruited. FNAC was done in accordance with stipulated clinical practice.Results: 53 patients with clinical and radiological suspicion of renal mass underwent FNAC of the kidney under ultrasound guidance. The age ranged from 1-2 year to 70 years (mean 44.7 years) with male to female ratio (1.9:1). Around 94.3% had primary renal mass, 1.9% metastatic tumor to the kidney and the rest 3.8% was undiagnosed. Sensitivity was 90% while specificity was 100%.Conclusions: We conclude that FNAC of the renal masses is safe and reliable, and fast diagnostic procedure in the evaluation of patient with renal masses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The role of ultrasonic guided fine needle aspiration cytology in the diagnoses of renal masses

2017

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Metabolic imaging with hyperpolarized ¹³C pyruvate magnetic resonance imaging in patients with renal tumors—Initial experience

Tang

Meng

Slater

et al. 2021

Cancer

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BACKGROUND Optimal treatment selection for localized renal tumors is challenging because of their variable biologic behavior and limitations in the preoperative assessment of tumor aggressiveness. The authors investigated the emerging hyperpolarized (HP) 13C magnetic resonance imaging (MRI) technique to noninvasively assess tumor lactate production, which is strongly associated with tumor aggressiveness. METHODS Eleven patients with renal tumors underwent HP 13C pyruvate MRI before surgical resection. Tumor 13C pyruvate and 13C lactate images were acquired dynamically. Five patients underwent 2 scans on the same day to assess the intrapatient reproducibility of HP 13C pyruvate MRI. Tumor metabolic data were compared with histopathology findings. RESULTS Eight patients had tumors with a sufficient metabolite signal‐to‐noise ratio for analysis; an insufficient tumor signal‐to‐noise ratio was noted in 2 patients, likely caused by poor tumor perfusion and, in 1 patient, because of technical errors. Of the 8 patients, 3 had high‐grade clear cell renal cell carcinoma (ccRCC), 3 had low‐grade ccRCC, and 2 had chromophobe RCC. There was a trend toward a higher lactate‐to‐pyruvate ratio in high‐grade ccRCCs compared with low‐grade ccRCCs. Both chromophobe RCCs had relatively high lactate‐to‐pyruvate ratios. Good reproducibility was noted across the 5 patients who underwent 2 HP 13C pyruvate MRI scans on the same day. CONCLUSIONS The current results demonstrate the feasibility of HP 13C pyruvate MRI for investigating the metabolic phenotype of localized renal tumors. The initial data indicate good reproducibility of metabolite measurements. In addition, the metabolic data indicate a trend toward differentiating low‐grade and high‐grade ccRCCs, the most common subtype of renal cancer. LAY SUMMARY Renal tumors are frequently discovered incidentally because of the increased use of medical imaging, but it is challenging to identify which aggressive tumors should be treated. A new metabolic imaging technique was applied to noninvasively predict renal tumor aggressiveness. The imaging results were compared with tumor samples taken during surgery and showed a trend toward differentiating between low‐grade and high‐grade clear cell renal cell carcinomas, which are the most common type of renal cancers.

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Renal Mass Biopsy

Ingham

Feldman

2018

Diagnosis and Surgical Management of Renal Tumors

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The accuracy of renal tumor biopsy: analysis from a national prospective study

Cited by 19 publications

References 25 publications

The role of ultrasonic guided fine needle aspiration cytology in the diagnoses of renal masses

The role of ultrasonic guided fine needle aspiration cytology in the diagnoses of renal masses

Metabolic imaging with hyperpolarized ¹³C pyruvate magnetic resonance imaging in patients with renal tumors—Initial experience

Renal Mass Biopsy

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The accuracy of renal tumor biopsy: analysis from a national prospective study

Cited by 19 publications

References 25 publications

The role of ultrasonic guided fine needle aspiration cytology in the diagnoses of renal masses

The role of ultrasonic guided fine needle aspiration cytology in the diagnoses of renal masses

Metabolic imaging with hyperpolarized 13C pyruvate magnetic resonance imaging in patients with renal tumors—Initial experience

Renal Mass Biopsy

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Product

Resources

About

Metabolic imaging with hyperpolarized ¹³C pyruvate magnetic resonance imaging in patients with renal tumors—Initial experience