The Accuracy of Thyroid Nodule Ultrasound to Predict Thyroid Cancer: Systematic Review and Meta-Analysis

Brito, Juan P.; Gionfriddo, Michael R.; Nofal, Alaa Al; Boehmer, Kasey R.; Leppin, Aaron L.; Reading, Carl C.; Callstrom, Matthew R.; Elraiyah, Tarig; Prokop, Larry J.; Stan, Marius N.; Murad, M. Hassan; Morris, John C.; Montori, Víctor M.

doi:10.1210/jc.2013-2928

Cited by 415 publications

(342 citation statements)

References 54 publications

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“…In this study, there was no statistically significant difference between malignant and benign nodules size. These contradictory results show that the size of the nodule is not reliable at predicting malignancy and should not be applied for medical decision making (12,13,(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Evaluation the Relationship Between Thyroid Nodule Size with Malignancy and Accuracy of Fine Needle Aspiration Biopsy (FNAB)

Godazandeh¹,

Kashi²,

Zargarnataj³

et al. 2016

Acta Inform Med

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Introduction: Some studies have shown largest thyroid nodule size, especially ≥4cm that can predict malignancy and reduce fine needle aspiration biopsy (FNAB) accuracy. Therefore, this study is designed to evaluate relationship between thyroid nodule sizes with malignancy and its effect on FNBA accuracy. Materials and Methods: a retrospective analytical study design aims to investigate all patients Positive and negative results of FNAB in all nodules were 3.5% and 6.3%, in <4cm nodules were 5.8% and 6.2% and in ≥4cm nodules were zero and 6.7%, respectively. The sensitivity, specificity, Positive predict value (PPV), negative predict value (NPV) and overall accuracy (OA) of FNAB in all nodules were 76.19%, 96.49%, 88.88%, 91.66% and 91.02%, and in <4cm nodules were 78.57%, 94.11%, 84.61%, 91.42% and 89.58%, and in ≥4cm nodules were 71.4%, 100%, 100%, 92% and 93.33%, respectively.Conclusion: the results of this study revealed that the size of the thyroid nodules is not reliable at predicting malignancy and should not be applied in medical decision making. FNAB showed good specificity but the sensitivity was low in our study. In ≥4cm nodules; FNAB sensitivity was decreased and accompanied by higher false-negative results. Furthermore, FNABs with suspicious results were associated with high probability of malignancy.

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Section: Discussionmentioning

confidence: 99%

Evaluation the Relationship Between Thyroid Nodule Size with Malignancy and Accuracy of Fine Needle Aspiration Biopsy (FNAB)

Godazandeh¹,

Kashi²,

Zargarnataj³

et al. 2016

Acta Inform Med

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“…4,6 More than 30 studies in the last year alone have examined the utility of thyroid nodule ultrasonography to predict malignancy based on different features. 4,[7][8][9][10] In a recent meta-analysis, Brito and colleagues 11 documented substantial heterogeneity across studies; the typical reporting schemes for thyroid ultrasounds are unclear, as is the practical utility of using ultrasounds to perform risk stratification of thyroid nodules. 11 The Thyroid Imaging and Reporting System (TI-RADS) was developed to provide a minimum common data set for standardized risk stratification of thyroid nodules.…”

mentioning

confidence: 99%

“…4,[7][8][9][10] In a recent meta-analysis, Brito and colleagues 11 documented substantial heterogeneity across studies; the typical reporting schemes for thyroid ultrasounds are unclear, as is the practical utility of using ultrasounds to perform risk stratification of thyroid nodules. 11 The Thyroid Imaging and Reporting System (TI-RADS) was developed to provide a minimum common data set for standardized risk stratification of thyroid nodules. 7,[12][13][14][15] For a thyroid ultrasound report to conform to TI-RADS it must include the following nodule characteristics: marked hypoechogenicity, taller-than-wide shape, microcalcifications, irregular margins and solid component in addition to size.…”

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confidence: 99%

The utility of thyroid ultrasonography in the management of thyroid nodules

Gamme

Parrington

Wiebe

et al. 2017

CJS

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Background: Ultrasonography for thyroid nodules is one of the most common imaging tests performed in the general population. Details from ultrasound reports guide biopsies and surgery. This study quantifies the completeness of these reports based on Thyroid Imaging and Reporting System (TI-RADS) criteria and considers their utility in predicting malignant disease. Methods:We retrospectively reviewed ultrasound reports for 329 thyroidectomy patients and extracted data elements using the TI-RADS criteria: nodule size, echogenicity, margins, vascularity, solid/cystic composition and the presence or absence of microcalcifications and the halo sign. We assessed the reports to determine whether individual or multiple criteria were associated with malignancy.Results: More than 97% of reports document nodule size; however, more than 90% of the reports noted only 3 or fewer of the 6 remaining TI-RADS criteria. The presence of microcalcifications was the most sensitive marker of malignancy (> 90%), whereas the documentation of irregular margins was the most specific indicator of malignancy (88%). Overall it was clear that microcalcifications, hypoechogenicity, irregular margins and solid nodules were significantly more likely to be found in malignant neoplasms; their absence predicted benign disease. Because so few reports consistently documented all criteria, the overall ability of thyroid ultrasonography to discriminate between lowerand higher-risk nodules is limited. Conclusion:Although the accuracy of thyroid ultrasonography is good, few ultrasound reports contain the necessary information, as defined by TI-RADS, to predict malignancy and guide management. When reported, microcalcifications and/or irregular margins are the best predictors of malignancy.Contexte : L'échographie des nodules thyroïdiens est l'une des épreuves d'imagerie les plus souvent effectuées dans la population générale. Les détails fournis par l'échographie guident les biopsies et la chirurgie. Cette étude quantifie l'exhaustivité des rapports d'échographie selon les critères TI-RADS (Thyroid Imaging and Reporting System) et en mesure l'utilité pour prédire les cancers.Méthodes : Nous avons passé en revue de façon rétrospective les rapports d'échographie de 329 patients ayant subi une thyroïdectomie et nous en avons extrait les éléments sous l'angle des critères TI-RADS : taille des nodules, échogénicité, marges, vascularité, composition solide c. kystique, présence ou absence de microcalcifications et signe du halo. Nous avons évalué les rapports afin de déterminer si certains critères individuels ou multiples pouvaient être associés au cancer.Résultats : Plus de 97 % des rapports mentionnent la taille des nodules; mais, plus de 90 % des rapports ne font état que de 3 critères ou moins sur les 6 autres critères TI-RADS. La présence de microcalcifications a été le marqueur tumoral le plus sensible (> 90 %), tandis que la présence de marges irrégulières a été le marqueur tumoral le plus spécifique (88 %). Dans l'ensemble, les microcalcifications, l'...

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“…Ayrıca yapılan çalışmalarda birçok özelliğin tiroid kanseri ile ilişkili olduğu bildirilmektedir ve çoğunluğu papiller tiroid kanseri (PTK)'dir. Bunlar, mikrokalsifikasyonlar, çevredeki tiroid veya strep kasları ile karşılaştırıldığında nodül hipoekojenitesi, düzensiz kenarlar (infiltratif, mikrolobule ve spiküle) ve transvers bir görünüm üzerinde ölçülen nodül boyunun eninden uzun olması olarak sayılabilir (KD 2) [8][9][10][11][12][13][14][15][16].İntranodüler Tiroid nodüllerinde güncel yaklaşım S a y f a | 20 vaskülarite özellikle folliküler tiroid kanserleriyle (FTK) ilişkili olarak saptanmıştır [12,17]. FTK, PTK'ye kıyasla sonografik özelliklerde bazı farklılıklar gösterir.…”

Section: Tiroid Nodüllerinde Ultrasonografiunclassified

Tiroid nodüllerine güncel yaklaşım: “2015 ATA” ve “2016 AACE/ACE/AME” kılavuzları derlemesi

Şişik¹,

Başak²,

Köse³

2017

Archives of Clinical and Experimental Medicine

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Clinical importance of the thyroid nodules arises from their malign potential. There are guidelines from several different organizations to determine follow-up options and, if necessary, surgical treatment options for thyroid nodules. Among them, the guidelines created by ATA and AACE/ACE/AME are accepted in many centers of the world. This paper aims to present the current status of ultrasound and fine needle aspiration biopsy in thyroid nodules in the context of the literature according to the updated versions of these guidelines.

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The Accuracy of Thyroid Nodule Ultrasound to Predict Thyroid Cancer: Systematic Review and Meta-Analysis

Cited by 415 publications

References 54 publications

Evaluation the Relationship Between Thyroid Nodule Size with Malignancy and Accuracy of Fine Needle Aspiration Biopsy (FNAB)

Evaluation the Relationship Between Thyroid Nodule Size with Malignancy and Accuracy of Fine Needle Aspiration Biopsy (FNAB)

The utility of thyroid ultrasonography in the management of thyroid nodules

Tiroid nodüllerine güncel yaklaşım: “2015 ATA” ve “2016 AACE/ACE/AME” kılavuzları derlemesi

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