The ACE rs1799752 Variant Is Associated with COVID-19 Severity but Is Independent of Serum ACE Activity in Hospitalized and Recovered Patients

Fricke-Galindo, Ingrid; Buendía-Roldán, Ivette; Ponce-Aguilar, Daniel I.; Pérez-Rubio, Gloría; Chávez‐Galán, Leslie; Alanis-Ponce, Jesús; Pérez-Torres, Karina; Rea, Daniela Valencia-Pérez; Téllez-Quijada, Fernanda; Nava-Quiroz, Karol J.; Hernández-Zenteno, Rafael de Jesús; Gutiérrez-Nava, Angélica; Falfán-Valencia, Ramcés

doi:10.3390/ijms24087678

Cited by 3 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the higher adherence of women to preventive health behaviors, female participants within our cohort might have adjusted their behavior regardless of their perceived vulnerability, whereas for men, factors such as vulnerability and/or the presence of comorbidities might have played a more decisive role. An alternative interpretation could be differences in genetic susceptibility between the study groups, where variations in specific alleles can increase susceptibility or resistance, on the one hand to infection with SARS-CoV-2 [ 49 , 50 ] and on the other hand to adverse health outcomes in COVID-19 disease [ 51 – 54 ]. In this context also, the results of the present contribution suggest that genetic susceptibility may be modulated by sex.…”

Section: Discussionmentioning

confidence: 99%

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Lecona,

Arroyo-Valerio,

Bueno-Hernández

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Throughout the early stages of the COVID-19 pandemic in Mexico (August—December 2020), we closely followed a cohort of n = 100 healthcare workers. These workers were initially seronegative for Immunoglobulin G (IgG) antibodies against SARS-CoV-2, the virus that causes COVID-19, and maintained close contact with patients afflicted by the disease. We explored the database of demographic, physiological and laboratory parameters of the cohort recorded at baseline to identify potential risk factors for infection with SARS-CoV-2 at a follow-up evaluation six months later. Given that susceptibility to infection may be a systemic rather than a local property, we hypothesized that a multivariate statistical analysis, such as MANOVA, may be an appropriate statistical approach. Our results indicate that susceptibility to infection with SARS-CoV-2 is modulated by sex. For men, different physiological states appear to exist that predispose to or protect against infection, whereas for women, we did not find evidence for divergent physiological states. Intriguingly, male participants who remained uninfected throughout the six-month observation period, had values for mean arterial pressure and waist-to-hip ratio that exceeded the normative reference range. We hypothesize that certain risk factors that worsen the outcome of COVID-19 disease, such as being overweight or having high blood pressure, may instead offer some protection against infection with SARS-CoV-2.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Lecona,

Arroyo-Valerio,

Bueno-Hernández

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

Role of angiotensin converting enzyme in pathogenesis associated with immunity in cardiovascular diseases

Li,

Ding,

Feng

et al. 2024

Life Sciences

View full text Add to dashboard Cite

Polymorphisms in the ACE I/D (rs4646994) and ACE2 G8790A (rs2285666) in Young Children Living in the Amazon Region and SARS-CoV-2 Infection

Pimenta,

Bonfim,

Figueiredo

et al. 2024

TropicalMed

View full text Add to dashboard Cite

COVID-19 infection caused by SARS-CoV-2 continues to cause significant mortality and morbidity. ACE2 is a key regulator of the renin–angiotensin–aldosterone system (RAAS). Differences in COVID-19 severity are thought to be due to the imbalance of RAAS/ACE mutations. This retrospective study evaluated the detection and genetic susceptibility to SARS-CoV-2 infection in 202 children ≤3 years of age living in the Amazon region in 2021. The angiotensin-converting enzyme ACE I/D (rs4646994) and ACE2 G8790A (rs2285666) polymorphisms were detected by SYBR GREEN real-time PCR and PCR-RFLP/Alul digestion, respectively. SARS-CoV-2 detection was performed by RT-qPCR in feces and saliva samples collected simultaneously from the same children presenting acute gastroenteritis (AGE) or acute respiratory infection (ARI). The frequency of SARS-CoV-2 detected by qRT-PCR in children was low (5.9%, 12/202), although higher in the group of children with AGE (8.9%, 9/101) than with ARI (2.9%, 3/101). Susceptibility to SARS-CoV-2 infection was not verified due to the low frequency. Homozygous II (rs4646994) children were the majority (87.1%, 176/202). Boys with genotype A (rs2285666) were more susceptible to ARI and pneumonia symptoms than AGE (OR = 3.8, 95% CI 1.4–10.3, p 0.007). Boys with genotype G (rs4646994) or the combination II + G were more susceptible to acquiring AGE. Surveillance, along with understanding their causes, is crucial to controlling ARI and COVID-19 in children living in low-income countries.

show abstract

The ACE rs1799752 Variant Is Associated with COVID-19 Severity but Is Independent of Serum ACE Activity in Hospitalized and Recovered Patients

Cited by 3 publications

References 37 publications

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Role of angiotensin converting enzyme in pathogenesis associated with immunity in cardiovascular diseases

Polymorphisms in the ACE I/D (rs4646994) and ACE2 G8790A (rs2285666) in Young Children Living in the Amazon Region and SARS-CoV-2 Infection

Contact Info

Product

Resources

About