The Acid Strength of Mono and Diesters of Phosphoric Acid. The n-Alkyl Esters from Methyl to Butyl, the Esters of Biological Importance, and the Natural Guanidine Phosphoric Acids

Synthesis of pH-responsive tertiary amine methacrylate polymer brushes and their response to acidic vapour

“…9,10 SIP has been used to grow polyelectrolyte brushes in the majority of recent studies, with the literature including many examples of both strong polyelectrolytes (quenched, i.e. charged under all conditions) and weak 45 polyelectrolytes ( annealed, with a dissociation constant that depends on pH and ionic strength). For weak polyelectrolyte brushes, the transition with pH from uncharged to charged grafted chains causes increased inter-chain repulsion (coulombic repulsion) and increased osmotic pressure 50 due to counter-ions, which can produce large changes in layer thickness.…”

“…Polymerisation of DPA catalysed by CuBr has a much greater initial growth rate than that catalysed by CuCl, with both systems exhibiting good control (linear thickness increase with time) for the first 3 h of the polymerisation. Indeed, the polymerisation remains well controlled up to 22 h when using 45 CuCl, whereas using CuBr leads to a retarded brush growth rate at long reaction times (most likely due to a greater radical concentration in this faster system, leading to a greater termination rate 40 ). phosphate and citrate buffers with time for a PDPA brush upon change of buffer solution form borate to monitored to ensure that the brush swelling had reached equilibrium, followed by thickness measurements via a spectroscopic scan.…”

“…22 45 Although a phosphate buffer spanned the pH range of interest for the swelling transition for both brushes, borate and citrate buffers were also used in this work to investigate higher and lower pH ranges respectively. It is clear that the apparent pK a values of the brushes are different depending on the choice of buffer.…”

The Spermine Phosphate-Bound Cyclooctaoxygen Sodium Epigenetic Shell of Euchromatin DNA Is Destroyed by the Epigenetic Poison Glyphosate

“…Foscarnet is a potent inhibitor of eukaryotic DNA polymerase  [74,75], an enzyme crucially involved in maintaining chromosomal integrity and telomere length. [58] and Kuhn & Kuhn [59] [pK′a,HG = apparent acid dissociation constant (25 °C) of haploid H. sapiens genome B-DNA double helix; pKa,R-OH = 1.29 = theoretical pKa (25 °C) [86] of one isolated internucleotide phosphodiester (R-OH) proton; s = 1 = number of statistical subunits on thread molecule [59]; j = 6 = number of spacing atoms (at least distance) in one dsDNA repeating unit [59]; b = 0.334 × 10 -7 cm (0.334 ± 0.01 nm [87]) = length rise in cm of one B- [103,104], creating an apurinic site [103][104][105]. Proton-catalysed N-glycosylation [110,111] at the 6-NH2 of adenine regenerates a nucleobase-inverted 2'-deoxynucleotide which is in furanose ring-opening equilibrium with its ald(os)imine form.…”

“…The intrinsic pKa of one isolated phosphodiester of DNA is 1.29, this is the pKa (25 °C) of dimethyl phosphate [86]. The reference H. sapiens genome size was taken as 3,238,442,024 bp (RefSeq assembly accession number GCF_000001405.…”