The Acorn Honey Used for a Published Study was Mistakenly Listed as <i>Quercus pyrenaica</i> and Should Be Corrected to <i>Quercus</i> species

Koçyiğit, Abdurrahim; Aydogdu, Gokhan; Balkan, Ezgi; Yenigün, Vildan Betül; Güler, Eray Metin; Bulut, Huri; Koktasoglu, Fatmanur; Gören, Ahmet; Atayoğlu, Ali Timuçin

doi:10.1177/15347354221110818

Cited by 1 publication

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cells were seeded in 6‐well cell culture plates at approximately 2×10 5 cells per well and incubated at 37 °C in 5 % CO 2 for 24 h. Then, the IC 50 (50 % inhibitory) concentrations of PE and 5‐FU and one concentration above the IC 50 value of PE were applied to cells alone and together then incubated for another 24 h. After the incubation period, cells were harvested using trypsin/EDTA and washed with PBS and the cell amount was adjusted to 2×10 5 cells/mL with PBS. Then, Comet Assay was performed as previously described [60] . Samples were visualized using a fluorescence microscope (Leica DM 1000, Solms, Germany).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Propolis Enhances 5‐Fluorouracil Mediated Antitumor Efficacy and Reduces Side Effects in Colorectal Cancer: An in Vitro and in Vivo Study

Kocyigit,

Guler,

Durmus

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

In this study, we investigated the combined treatment of 5‐fluorouracil (5‐FU) and Anatolian propolis extract (PE) on colorectal cancer (CRC)using in vitro and in vivo studies. We exposed luciferase‐transfected (Lovo‐Luc CRC) cells and healthy colon cells (CCD‐18Co) to varying concentrations of 5‐FU and PE to assess their genotoxic, apoptotic, and cytotoxic effects, as well as their intracellular reactive oxygen species (iROS) levels. We also developed a xenograft model in nude mice and evaluated the anti‐tumor effects of PE and 5‐FU using various methods. Our findings showed that the combination of PE and 5‐FU had selectivity against cancer cells, particularly at higher doses, and enhanced the anti‐tumor effectiveness of 5‐FU against colon CRC. The results suggest that PE can reduce side effects and increase the effectiveness of 5‐FU through iROS generation in a dose‐dependent manner.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Then, Comet Assay was performed as previously described. [60] Samples were visualized using a fluorescence microscope (Leica DM 1000, Solms, Germany). DNA's were analyzed using the package program (Comet IV, Perceptive Instruments, Suffolk, UK).…”

Section: Genotoxicity Assaymentioning

confidence: 99%