The acquisition of tolerance toward cow's milk through probiotic supplementation: A randomized, controlled trial

Hol, Jeroen; Leer, E. H. G. Van; Schuurman, Beatrix E. E. Elink; Ruiter, Lilian F. de; Samsom, Janneke N.; Hop, Wim C. J.; Neijens, H. J.; Jongste, Johan C. de; Nieuwenhuis, Edward E. S.

doi:10.1016/j.jaci.2008.03.018

Cited by 169 publications

(143 citation statements)

References 44 publications

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“…In contrast, supplementation of Lctbs casei and Bfdbm Bb-12 to extensively hydrolyzed formula did not accelerate cow's milk tolerance in infants with cow's milk allergy [61]. Moreover, a few RCTs also showed no effects of probiotics, specifically LGG or Lctbs acidophilus, in protection against cow's milk allergy in infancy [54,56,62,63].…”

Section: Ige-sensitized (Atopic) Versus Non-ige-sensitized (Non-atopimentioning

confidence: 95%

Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data

Özdemir

2010

Clinical and Experimental Immunology

176

138

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SummaryEpidemiological data show that allergic children have a different intestinal flora from healthy children with higher levels of Clostridia and lower levels of Bifidobacteria. Nonetheless, Bifidobacteria and Lactobacilli are found more commonly in the composition of the intestinal flora of non-allergic children. Probiotics are ingested live microbes that can modify intestinal microbial populations in a way that benefits the host and they are represented mainly by Lactobacilli. Enhanced presence of probiotic bacteria in the intestinal microbiota is found to correlate with protection against atopy. There is also very promising evidence to recommend the addition of probiotics to foods for the prevention and treatment of allergic diseases. Clinical improvement, especially in allergic rhinitis and immunoglobulin (Ig)E-sensitized (atopic) eczema, has been reported in most of the published studies. However, clinical benefit of probiotic therapy depends upon numerous factors, such as type of bacterium, dosing regimen, delivery method and other underlying host factors, e.g. the age and diet of the host. Selection of the most beneficial probiotic strain, the dose and the timing of supplementation still need to be determined. This review helps understanding of the role of probiotics in various allergic diseases, explaining laboratory and clinical data in light of recent literature.

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Section: Ige-sensitized (Atopic) Versus Non-ige-sensitized (Non-atopimentioning

confidence: 95%

Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data

Özdemir

2010

Clinical and Experimental Immunology

176

138

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“…Nonetheless, their efficacy and tolerance has still not been proven (FAO/WHO, 2002;AFSSA, 2003;Agostoni et al, 2004Agostoni et al, , 2007Osborn and Sinn, 2007;Hol et al, 2008;Kopp et al, 2008;Lee et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

et al. 2010

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Background/Objectives: To determine the impact of a not hydrolyzed fermented infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus thermophilus 065 (HKBBST) on the incidence of allergy-like events during the first 2 years of life in children at high risk of atopy. Subjects/Methods: This multicenter, randomized, double-blind, controlled study included infants at high risk of atopy. Infants used HKBBST or a standard infant formula (SIF) since birth until 1 year of age, and were followed at 4, 12 and 24 months after birth. Skin prick tests (SPTs) for six foods and six aeroallergens were systematically performed and adverse events (AEs) were recorded. In case of potentially allergic AE (PAAE), allergy could be further tested by SPT, patch tests and quantification of specific IgEs. If cow's milk allergy (CMA) was suspected, an oral challenge could also be performed. Results: The study included 129 children, 63 were randomized to SIF, 66 to HKBBST. The use of HKBBST milk did not alter the proportion of CMA but decreased the proportion of positive SPT to cow's milk (1.7 vs 12.5%, P ¼ 0.03), and the incidence of digestive (39 vs 63%, P ¼ 0.01) and respiratory potentially allergic AEs (7 vs 21%, P ¼ 0.03) at 12 months, and that of respiratory PAAEs at 24 months (13 vs 35%, P ¼ 0.01). Conclusions: HKBBST decreased the incidence of PAAEs in children with family history of atopy, during the first months of life and after the formula was stopped. Oral tolerance to cow's milk in infants at high risk of atopy may therefore be improved using not hydrolyzed fermented formulae.

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“…The proposed health benefits include reduction of intestinal infection risk, allergies, and atopic eczema (6,7) and relief from symptoms of inflammatory bowel disease (IBD) (8). However, placebo-controlled cross-over studies to scientifically support these health claims have shown different success rates (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

mentioning

confidence: 99%

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

Baarlen

Troost

Meer

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

299

234

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Probiotic bacteria, specific representatives of bacterial species that are a common part of the human microbiota, are proposed to deliver health benefits to the consumer by modulation of intestinal function through largely unknown molecular mechanisms. To explore in vivo mucosal responses of healthy adults to probiotics, we obtained transcriptomes in an intervention study after a double-blind placebo-controlled cross-over design. In the mucosa of the proximal small intestine of healthy volunteers, probiotic strains from the species Lactobacillus acidophilus, L. casei, and L. rhamnosus each induced differential gene-regulatory networks and pathways in the human mucosa. Comprehensive analyses revealed that these transcriptional networks regulate major basal mucosal processes and uncovered remarkable similarity to response profiles obtained for specific bioactive molecules and drugs. This study elucidates how intestinal mucosa of healthy humans perceives different probiotics and provides avenues for rationally designed tests of clinical applications.gene regulation | host-microbe interactions | lactobacillus | transcriptomics | gut bacteria

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The acquisition of tolerance toward cow's milk through probiotic supplementation: A randomized, controlled trial

Cited by 169 publications

References 44 publications

Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data

Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

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