The action behind the words: embryonic stem cell research marches on

Leslie, Mitch

doi:10.1083/jcb.200608162

Cited by 4 publications

(2 citation statements)

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“…Stem cells have been extensively reviewed and have been the subject of much scientific interest. 3–7 In addition, they have clearly captivated public attention, speculation and controversy over methods of derivation and appropriate usages. 8,9 Here, I define ‘stem cell’ as having the capacity to replicate indefinitely while maintaining an ability to form cells from the ectoderm, endoderm and mesoderm lineages.…”

Section: Stem and Progenitor Cellsmentioning

confidence: 99%

Patient heal thyself: modeling and treating neurological disorders using patient-derived stem cells

Ess

2013

Exp Biol Med (Maywood)

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Disorders of the brain and spinal cord are common worldwide problems but have remained very difficult to treat. As a group they have diverse etiologies and can be due to trauma, infection, tumors, genetic mutations and environmental insults. Though distinct in etiology, neurological disorders share an overall intractability as current therapies are largely limited to treatment of symptoms. Improved outcomes are further constrained by the minimal endogenous capacity of the brain and spinal cord for repair. Spectacular recent scientific advances, however, suggest that new stem cell-based approaches may change this undesirable situation. In this review, I will broadly outline the challenges of studying and treating disorders of the brain and spinal cord. I will review ongoing attempts to use stem cell-based therapies to both model and treat neurological disorders. While this field is in its infancy, expected advances and needed breakthroughs point to a future where patient-derived stem cells will be the basis for the emerging discipline of regenerative neurology.

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Section: Stem and Progenitor Cellsmentioning

confidence: 99%

Patient heal thyself: modeling and treating neurological disorders using patient-derived stem cells

Ess

2013

Exp Biol Med (Maywood)

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“…Although the embryos are either surplus and destined to be destroyed under tissue banking regulations if not used or not of good enough quality to implant, they are thought of as viable, and some people have an antipathy to using them for research (Gruen & Grabel, 2006). In the Unites States, the use of Federal money for hESC research on new lines is prohibited and as such progress in this field has been significantly suppressed in America in contrast to, for example Singapore or the UK where legislation is more permissive (Leslie, 2006). However, these objections have led to the search for alternative sources that would not destroy viable embryos.…”

Section: Sources Of Hescmentioning

confidence: 99%

Human embryonic stem cells: origins, characteristics and potential for regenerative therapy

Mountford

2008

Transfusion Medicine

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Stem cells and their use in regenerative therapies are currently hot topics in both biology and medicine. For transfusion scientists the concept of cell therapy is not a new idea but rather a fundamental practice in this field. Bone marrow transplantation was pioneered in the 1960s and relies on the capacity of haemopoietic stem cells in the donated bone marrow to completely reconstitute the blood system of the recipient. Although this capacity of adult (or somatic) stem cells to regenerate the tissue from which they arise is extremely important, the isolation and cultivation of human embryonic stem cells (hESCs) have opened up the possibility to generate any cell or tissue of the body. This characteristic of hESC offers the hope of cell replacement and regenerative therapy for a whole array of diseases, many of which are currently untreatable. However, in order to understand the potential advantages and disadvantages of using stem cells in regenerative medicine, it is necessary to fully understand their origin, characteristics and potential. This review will concentrate particularly on hESCs and their derivation, characterization and capacity to differentiate into clinically useful tissue including haemopoietic lineages.

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Stem Cell Research and Biopsychosocial Perspectives From the Sciences, Government, and Community

Montero

Forrester

Grannan

et al. 2009

WHUM

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The action behind the words: embryonic stem cell research marches on

Abstract: Talk of policy has dominated talk of science for those interested in embryonic stem cell science. But research is continuing, and the advances are making clear why embryonic stem cells are such an important scientific and medical resource.

Cited by 4 publications

References 14 publications

Patient heal thyself: modeling and treating neurological disorders using patient-derived stem cells

Patient heal thyself: modeling and treating neurological disorders using patient-derived stem cells

Human embryonic stem cells: origins, characteristics and potential for regenerative therapy

Stem Cell Research and Biopsychosocial Perspectives From the Sciences, Government, and Community

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