The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes

Yoshikawa, Yutaka; Ueda, Eriko; Kojima, Yoshitane; Sakurai, Hiromu

doi:10.1016/j.lfs.2004.02.006

Cited by 72 publications

(62 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zinc is involved in insulin physiology: it is found in the insulin molecule, and in secretory granules, and has been shown to participate in insulin synthesis, stabilization of proinsulin and insulin hexamers, insulin secretion, insulin sensitivity, and insulin degradation [27] . Zinc has also been reported to have insulin-like effects, strengthening the mitogenic signaling of insulin and activating the extracellular-signal-regulated kinases 1 and 2 [48,49] . Cpeptide is released from the ␤ -cells in equimolar amounts with insulin.…”

Section: Discussionmentioning

confidence: 99%

Effect of Diet Intervention and Oral Zinc Supplementation on Metabolic Control in Berardinelli-Seip Syndrome

Rocha¹,

Leite

Baracho³

et al. 2010

Ann Nutr Metab

View full text Add to dashboard Cite

Background/Aims: Berardinelli-Seip syndrome (BSS), also termed congenital generalized lipodystrophy or congenital generalized lipoatropic diabetes, is a rare autosomal recessive disease characterized by the nearly complete absence of metabolically active adipose tissue from birth, extreme insulin resistance, diabetes mellitus, and hepatomegaly. The aim of this study was to evaluate the effect of diet intervention and oral zinc supplementation on the metabolic control of BSS patients. Methods: During a 3-month period, 10 BSS patients received individualized diets and oral zinc supplementation. Food intake, clinical laboratory parameters, serum zinc and leptin, and plasma C-peptide concentrations were evaluated at the beginning of the study and after 3 months. Results: At the beginning of the study, all patients had elevated energy, protein, total fat, carbohydrate, calcium, iron, and zinc intakes. After 3 months, all of these parameters had decreased. Total fiber intakes remained low before and after diet intervention and oral zinc supplementation, and plasma levels of fasting glucose remained high. In contrast, glycated hemoglobin decreased significantly. Plasma leptin, C-peptide, and serum zinc levels increased during venous zinc tolerance testing, but there were no significant differences between the 2 curves obtained before and after diet intervention and oral zinc supplementation. Conclusions: Diet intervention and oral zinc supplementation were effective at controlling energy consumption, macronutrients, and glycated hemoglobin. Zinc likely acts as an adjunct therapy, thereby improving the effectiveness of leptin.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Diet Intervention and Oral Zinc Supplementation on Metabolic Control in Berardinelli-Seip Syndrome

Rocha¹,

Leite

Baracho³

et al. 2010

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Disturbances in zinc homeostasis, and in particular zinc depletion, in the pancreas have been associated with oxidative stress [39]. In some studies, zinc supplementation has been found to reduce the progression of diabetes by reducing oxidative stress and apoptosis [40][41][42]. Zinc plays a major role in the maintenance of the structural integrity of copper zinc superoxide dismutase (Cu-Zn SOD) [43].…”

Section: Zinc As An Antioxidantmentioning

confidence: 99%

Zinc and Zinc Transporter Regulation in Pancreatic Islets and the Potential Role of Zinc in Islet Transplantation

Bosco¹,

Mohanasundaram²,

Drogemuller³

et al. 2010

Rev Diabet Stud

View full text Add to dashboard Cite

■ AbstractThe critical trace element zinc is essential for normal insulin production, and plays a central role in cellular protection against apoptosis and oxidative stress. The regulation of zinc within the pancreas and β-cells is controlled by the zinc transporter families ZnT and ZIP. Pancreatic islets display wide variability in the occurrence of these molecules. The zinc transporter, ZnT8 is an important target for autoimmunity in type 1 diabetes. Gene polymorphisms of this transporter confer sensitivity for immunosuppressive drugs used in islet transplantation. Understanding the biology of zinc transport within pancreatic islets will provide insight into the mechanisms of β-cell death, and may well reveal new pathways for improvement of diabetes therapy, including islet transplantation. This review discusses the possible roles of zinc in β-cell physiology with a special focus on islet transplantation.

show abstract

“…9). The following results were obtained: 104,168 (1) vanadyl and its complexes act on at least four sites involving the tyrosine kinase of the insulin receptor, signal transduction glucose transporter (GLUT4) and PDE, in the ''ensemble mechanism,'' (2) zinc(II) ion and its complexes strongly act on GLUT4 and PDE, and (3) [Zn(pa) 2 ] complex acts on the insulin receptor. These results were observed at the molecular level.…”

Section: Insulin-mimetic Action Mechanism Of Vanadium and Zinc Complexesmentioning

confidence: 99%

Chemistry and Biochemistry of Insulin-Mimetic Vanadium and Zinc Complexes. Trial for Treatment of Diabetes Mellitus

Sakurai¹,

Katoh²,

Yoshikawa³

2006

Bulletin of the Chemical Society of Japan

Self Cite

View full text Add to dashboard Cite

The number of patients suffering from diabetes mellitus (DM), which is a chronic metabolic disorder and mainly classified as either insulin-dependent type 1 or non-insulin-dependent type 2, is increasing throughout the world. The sequence of DM progression makes this disease a major health risk in regard to microvascular disease that leads to kidney failure, blindness, and nerve damage as well as macrovascular disease that leads to amputations, cardiovascular disease, and stroke. To treat DM, several types of insulin preparations and synthetic drugs for type 1 and type 2 DM, respectively, are in clinical use. However, there are several problems concerning the insulin preparations and synthetic drugs, such as physical and mental pain due to daily insulin injections and defects involving several side effects, respectively. Thus, the disease demands extraordinary effects to define pathobiochemical pathways and strategies for prevention and to find new therapeutic approaches. For this purpose, oxovanadium(IV) (vanadyl, VO 2þ ) and zinc(II) containing complexes have been explored as treatments for both types of DM. This article reviews the current state of research on insulin-mimetic and antidiabetic metal complexes, with special focus on paramagnetic vanadyl and diamagnetic zinc(II) complexes with different coordination modes, together with possible reaction mechanisms. New drug delivery systems involving enteric-coated capsulation and a biopolymer are also reviewed.One of the most important findings in the 20th century was that metal ions and their biomolecular complexes are essential for life on the earth and play roles in not only metalloproteins and metalloenzymes but also gene expression.1,2 This fundamental knowledge showed that our health, aging, physiological disorders and diseases are related to the state of the metal ions and their biomolecular complexes in our body. Some clinically useful metal-containing compounds and metal complexes known as metallopharmaceuticals that can regulate human health have been developed to treat or cure many types of diseases. The most distinctive examples are the platinum (Pt) anti-tumor agents, cisplatin and related newly developed Pt complexes, the gold (Au) orally active anti-rheumatoidal agent auronofin, the aluminum (Al) and zinc (Zn) anti-ulcer agents scralfate and polaprezinc, respectively, the selenium (Se) antiinflammatory agent ebselen, and the lithium (Li) anti-manicdepressive agent lithium carbonate.

show abstract

The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes

Cited by 72 publications

References 33 publications

Effect of Diet Intervention and Oral Zinc Supplementation on Metabolic Control in Berardinelli-Seip Syndrome

Effect of Diet Intervention and Oral Zinc Supplementation on Metabolic Control in Berardinelli-Seip Syndrome

Zinc and Zinc Transporter Regulation in Pancreatic Islets and the Potential Role of Zinc in Islet Transplantation

Chemistry and Biochemistry of Insulin-Mimetic Vanadium and Zinc Complexes. Trial for Treatment of Diabetes Mellitus

Contact Info

Product

Resources

About