From the Lister Institute, London Both female and male sexual hormones have been found in the female organism (Koch, 1936;Dingemanse, Borchardt, and Laqueur, 1937), and some have already been isolated in a pure form, while others, mostly those concerned in male activities, are as yet unidentified. In the experiments we performed on rats two lines of inquiry were followed systematically-namely, examination of the bisexual properties of the sexual hormones and investigation of their co-operative activity. It is now possible to draw general conclusions. Therefore in the present paper I propose to outline the results obtained at the Lister Institute in experiments some of which have already been published and some of which are unpublished, and also to discuss the possible clinical significance of these findings.