1975
DOI: 10.1111/j.1476-5381.1975.tb07420.x
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THE ACTION OF ACETYLCHOLINE ANTAGONISTS ON AMINO ACID RESPONSES IN THE FROG SPINAL CORD in vitro

R.A. NICOLL

Abstract: I The isolated hemisected frog spinal cord has been used to study the action of acetylcholine antagonists on amino acid responses by means of sucrose gap recording. 2 Primary afferents and motoneurones were shown to contain few, if any, cholinoceptors, since acetylcholine and carbachol responses were essentially abolished when synaptic transmission was blocked with magnesium ions or when action potentials were blocked by tetrodotoxin.3 Curare antagonized the y-aminobutyric acid (GABA) and ,B-alanine depolariza… Show more

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Cited by 27 publications
(8 citation statements)
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“…Similar results were obtained here with ciliary ganglion GlyRs. dTC, which blocks AChRs at micromolar concentrations, also blocks GABA responses in frog spinal cord neurons (Nicoll, 1975;Bixby & Spitzer, 1984) and ciliary ganglion GlyRs, as shown here, when used at high concentrations. Strychnine has much greater affinity for GlyRs than for GABAA receptors (e.g.…”
Section: Comparison With Glyrs In the Cnssupporting
confidence: 77%
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“…Similar results were obtained here with ciliary ganglion GlyRs. dTC, which blocks AChRs at micromolar concentrations, also blocks GABA responses in frog spinal cord neurons (Nicoll, 1975;Bixby & Spitzer, 1984) and ciliary ganglion GlyRs, as shown here, when used at high concentrations. Strychnine has much greater affinity for GlyRs than for GABAA receptors (e.g.…”
Section: Comparison With Glyrs In the Cnssupporting
confidence: 77%
“…Bicuculline is a competitive antagonist of GABAA receptors, but its specificity has been questioned (Hill, Simmonds & Straughan, 1976;Zhang & Feltz, 1991 (Nicoll, 1975;Hill et al 1976;Lebeda, Hablitz & Johnston, 1982;Bixby & Spitzer, 1984). dTC inhibited responses induced by 40 /M glycine from ciliary ganglion neurons in a dose-dependent manner (Fig.…”
Section: Glycine-induced Currents In Ciliary Ganglion Neuronsmentioning
confidence: 99%
“…When indirect responses were blocked by using 2 mM Mn2+/0.4 mM Ca2' Ringer (cf. Nicoll, 1975), carbachol or ACh produced only small and variable responses on VR or DR. These responses, presumably resulting from activation of acetylcholine receptors on primary afferents or motoneurones, were not completely antagonized by DHj3E.…”
Section: Characterization Of Convulsant Effects Of Dendrotoxinmentioning
confidence: 85%
“…Neither mecamylamine, a-bungarotoxin nor atropine showed any tendency to induce DTOXlike convulsant activity. Although (+)-tubocurarine is known to promote convulsant activity in the isolated spinal cord of the frog, this is probably due to an anti-GABAergic rather than anticholinergic action of the drug (Nicoll, 1975).…”
Section: Methodsmentioning
confidence: 98%
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