The action of chlorpromazine on exploration in pairs of rats

File, Sandra E.; Pope, J. H.

doi:10.1007/bf00421538

Cited by 30 publications

(9 citation statements)

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“…This hypothesis is supported by the behavioural profiles of Wistar rats obtained from different breeders (Rex et al 1996) and by the inconsistent outcome of animal tests for anxiety following treatment with serotonergic agents (Griebel 1995). An additional effect might have the size of the open field in our study (1 m 2 ), compared to the size of the "original" test arena (0.36 m 2 , File and Pope 1974;0.42 m 2 , File and Hyde 1978), but a recent study showed that the open field behaviour is not closely related to the size of the arena (Eilam 2003).…”

Section: Discussionmentioning

confidence: 65%

“…The social interaction test, introduced by Cappell and Latane (1969) and developed by File and Pope (1974), is a simple protocol that has been used in rats (Vellucci and File 1979;Cadogan et al 1994), mice (De Angelis and File 1979;Crawley 1985) and gerbils (Cheeta et al 2001). The test relies on a rodents' natural tendency to avoid bright light and unfamiliar surroundings.…”

Section: Introductionmentioning

confidence: 99%

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Anxiolytic-like profile in Wistar, but not Sprague?Dawley rats in the social interaction test

et al. 2004

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like profile in Wistar, but not Sprague?Dawley rats in the social interaction test

et al. 2004

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“…During 10 min, the duration of any activity in seconds was recorded. Exploratory activity (File and Pope 1974). During 3 min of observation, the number of deepings (nose pokes) by rats on a board with 16 apertures was recorded.…”

Section: Methodsmentioning

confidence: 99%

Histaminergic Activity in a Rodent Model of Parkinson’s Disease

et al. 2009

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Rats lesioned shortly after birth with 6-OHDA have been proposed to be a near-ideal model of severe Parkinson's disease, because of non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, and near-total dopamine (DA) denervation of striatum. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increased. Therefore, the aim of this study was to determine histamine content in the brain and the effect of histamine receptor antagonists on behavior of adult rats. At 3 days after birth, Wistar rats were pretreated with desipramine (20.0 mg/kg ip) 1 h before bilateral icv administration of the catecholaminergic neurotoxin 6-OHDA (67 microg base, on each side) or saline-ascorbic acid (0.1%) vehicle (control). At 8 weeks levels of DA and its metabolites L: -3,4-dihydroxyphenylalanine (DOPAC) and homovanillic acid (HVA) were estimated in the striatum and frontal cortex by HPCL/ED technique. In the hypothalamus, hippocampus, frontal cortex, and medulla oblongata, the level of histamine was analyzed by immunoenzymatic method. Behavioral observations (locomotion, exploratory-, oral-, and stereotyped-activity) were additionally made on control and 6-OHDA neonatally lesioned rats. Effects of DA receptor agonists (SKF 38393, apomorphine) and histamine receptor antagonists (e.g., S(+)chlorpheniramine, H(1); cimetidine, H(2); thioperamide, H(3) agonist) were determined. We confirmed that 6-OHDA significantly reduced contents of DA and its metabolites in the brain in adulthood. Histamine content was significantly increased in the hypothalamus, hipocampus, and medulla oblongata. Moreover, in 6-OHDA-lesioned rats behavioral response was altered mainly by thioperamide (H(3) antagonist). These findings indicate that histamine and the central histaminergic system are altered in the brain of rats lesioned to model Parkinson's disease, and that histaminergic neurons exert a modulating role in Parkinsonian 6-OHDA-lesioned rats.

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“…Tests based on conditioned fear / aversion, as the conditionedemotional-response test (Davis 1990), the Geller-Seifter test, or the bird-punished-drinking test (Geller 1960) and last but not least 3. unconditioned tests, inducing anxiety by a new aversive environment, leading to behavioural inhibition. The unconditioned tests of anxiety include the X-maze (Handley and Mithani 1984), the black and white box test (Crawley and Goodwin 1980), the modified open field test , the social interaction test (Cappell and Latane 1969;File and Pope 1974) and the free exploratory paradigm (Griebel et al 1993). In unconditioned tests a conflict situation is created for the animals and changes in the innate behaviour in this aversive situation are observed.…”

Section: Historical Developmentsmentioning

confidence: 99%