The Action of Diazepam on Human Skeletal Muscle

Ludin, H. P.; Robert, F.

doi:10.1159/000114333

Cited by 7 publications

(4 citation statements)

References 5 publications

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Section: Neuromuscular Transmission In Vivomentioning

confidence: 93%

“…by CRAWLEY (1970) andBRADSHAW andMADDISON (1979) and reduced at an oral dose of 0.4 mg' kg-I by LUDIN and ROBERT (1974). The contractile force after tetanic stimulation and the electromyographically recorded muscle evoked potentials were unaffected (LUDIN and ROBERT, 1974). In spastic patients with total or incomplete spinal lesions, action potential and twitch tension of the soleus muscle after popliteal nerve stimulation were reduced, whereas the latencies or the half-time of contraction or relaxation were unchanged (15-20 mg, VERRIER et aI., 1976).…”

Section: Neuromuscular Transmission In Vivomentioning

confidence: 96%

See 1 more Smart Citation

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Haefely¹,

Pieri²,

Polc³

et al. 1981

Handbook of Experimental Pharmacology

114

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Section: Neuromuscular Transmission In Vivomentioning

confidence: 93%

Section: Neuromuscular Transmission In Vivomentioning

confidence: 96%

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Haefely¹,

Pieri²,

Polc³

et al. 1981

Handbook of Experimental Pharmacology

114

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“…It is not known whether the muscle relaxant effects of diazepam are central or peripheral. In some studies specific receptors for diazepam have not been found in adult skeletal muscle (2); in other studies, direct effects on skeletal and cardiac muscle were observed (3).…”

mentioning

confidence: 99%

Diazepam Inhibits Myoblast Fusion and Expression of Muscle Specific Protein Synthesis

Bandman

Walker

Strohman

1978

Science

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The presence of diazepam in culutres of chicken embryo myoblasts arrests normal muscle cell differentiation. High concentrations of the drug reversibly prevent myoblasts from fusing to form multinucleated myotubes. Lower concentrations of diazepam allow cell fusion to occur, but inhibit the synthesis and accumulation of myosin heavy chain, implying that cell fusion does not obligate myoblasts to synthesize and accumulate large quantities of muscle specific protein. The effect of diazepam on muscle cells in culture is direct and specific.

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“…The absence of effect of clinical doses of diazepam on the neuromuscular blocking of twitch tension is often considered as an argument against any peripheral motor effect of this and other benzodiazepines in humans. However, studies with diazepam using the method of comparing electromyogram (EMG) with contractile force did show a direct peripheral effect on muscle contraction (Ludin and Dubach, 1971;Ludin and Robert, 1974). In the study of Ludin and Dubach (1971) one group of healthy volunteers received intramuscular 0.32-0-43 mg diazepam per kilogram bodyweight.…”

mentioning

confidence: 99%

The effects of lormetazepam on contractile force of the gastrocnemius muscle and on memory of healthy young volunteers

Deijen

Heemstra

Orlebeke

et al. 1989

Human Psychopharmacology

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One group of 10 young subjects were tested twice; in one test session 2 mg lormetazepam, in the other session placebo was administered, in random order. One subject dropped out. In one test session contractile force measurements were made six times; one measurement took place before treatment and the other measurements after treatment with the study medication. Each measurement of contractile force consisted of pushing weights of 0 to 10 kg and exerting maximal force. The corresponding electromyogram (EMG) of the gastrocnemius muscle was recorded. For the forces of 0 to 10kg the regression was established of EMG on contractile force. Treatment effects on memory were investigated by means of a selection of tests, covering short-term and long-term memory, in terms of recall and recognition. Analyses of covariance were performed on the regression coefficients of EMG/ contractile force and on the data of maximally exerted force, the pretreatment scores serving as covariate. These analyses did not result in any difference for the two treatment conditions, leading to the conclusion that the administration of lormetazepam did not have any direct action on the contractile systems of human muscle. The t-tests performed on the memory data resulted in a significant impairment of performance on the long-term memory tasks, whereas short-term memory was not impaired. It is concluded that, in accordance with previous research, the administration of lormetazepam results in an impairment in the acquisition of new information in long-term memory, but also in impaired retention.KEY worn-Lormetazepam, contractile force, gastrocnemius muscle, electromyogram, short-term memory, long-term memory.One of the actions of the benzodiazepines is muscle relaxation. This skeletal muscle relaxing effect is generally considered t o originate in the central nervous system. There is substantial evidence that the depressant effect is caused by the action of benzodiazepines on spinal and supraspinal motor systems (Haefely et al., 1981). In addition to the relaxing effects of benzodiazepines on skeletal muscle, resulting from their action on spinal and supraspinal levels, there is increasing evidence that benzodiazepines also directly affect peripheral neuromuscular function (Haefely et al., 198 1).Research o n this direct peripheral action has been based on (1) in-vitro nerve-muscle preparations, (2) in-vivo muscle preparations of animals (cat or rat) and (3) human (anaesthetized) patients or volunteers.Regarding research on in-vitro nerve-muscle preparations, Driessen (1984)

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The Action of Diazepam on Human Skeletal Muscle

Cited by 7 publications

References 5 publications

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Diazepam Inhibits Myoblast Fusion and Expression of Muscle Specific Protein Synthesis

The effects of lormetazepam on contractile force of the gastrocnemius muscle and on memory of healthy young volunteers

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