The action of excessive, inorganic silicon (Si) on the mineral metabolism of calcium (Ca) and magnesium (Mg)

Najda, Jacek; Gmiński, Jan; Drózdz, M; Danch, Alojzy

doi:10.1007/bf02783786

Cited by 18 publications

(11 citation statements)

References 11 publications

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“…Silicon may be an essential element for human. A previous research showed silicon plays an essential part in the metabolism of calcium and magnesium [41]. Furthermore, another research indicated ingestion of trisilicate may result in the formation stone entirely or partially composed of silica [42].…”

Section: Discussionmentioning

confidence: 99%

Systemic analysis of urinary stones from the Northern, Eastern, Central, Southern and Southwest China by a multi-center study

Luo

et al. 2018

BMC Urol

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BackgroundTo provide some basis for the prevention of urinary stones in general population, we did a systemic analysis of urinary stones from Northern, Eastern, Central, Southern and Southwest China by a multi-center study.MethodsA total of 11,157 urinary stones from Northern, Eastern, Central, Southern and Southwest China were obtained and analyzed by Fourier transform infrared spectroscopy. Combined with scanning electron microscopy and X-ray energy spectrometer, urinary stones were classified into different types. Furthermore, the correlation between stone types and clinical characteristics, as well as their regional distribution were elucidated.ResultsCalcium oxalate stones were the most common type in each region, followed by calcium oxalate-calcium phosphate mixed stones, uric acid stones and calcium phosphate stones. The distribution of calcium oxalate stones were highest prevalence in Southwest China (67.9%, P < 0.05), followed by Eastern and Northern China. Anhydrous uric acid stones, with a constituent ratio of 19.3% in Southern China, and 13.7% in Central China, were significantly higher than that in other regions (P < 0.05). Elements analysis indicated varieties among stone types as well as distribution regions. Moreover, the clinical characteristics were highly correlated with stone types and anatomical locations but not their distribution regions.ConclusionsThe material and elements composition of urinary stones among different regions showed some varieties. Calcium oxalate stone has the highest constituent ratio in Southwest China, while anhydrous uric acid stone has the highest constituent ratio in Southern China. Moreover, the clinical characteristics were highly correlated with stone types and anatomical locations but not their distribution regions.

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Section: Discussionmentioning

confidence: 99%

Systemic analysis of urinary stones from the Northern, Eastern, Central, Southern and Southwest China by a multi-center study

Luo

et al. 2018

BMC Urol

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“…Evidence of Si's influence on bone mineralisation [11,31,40,41], metabolism [19,[42][43][44], collagen synthesis [19,45] and crosslinking [46] is compelling. In this study, both the presence and level of Si had a profound effect on bone apposition.…”

Section: Biological Sensitivity To Silicate Substitution and Substitumentioning

confidence: 98%

Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds

Hing

Revell

Smith³

et al. 2006

Biomaterials

343

258

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“…Silicon has been proposed to help regulate calcium and magnesium homeostasis, but mechanistic details are lacking. 131 Of note, chronic use of antacid trisilicates can lead to increased urinary stone formation, and these stones are rich in silicon and have less calcium content than commonly found in calcium-based stones. 132,133 No evidence exists that altering silicon homeostasis affects lithogenic risk.…”

Section: The Elementome Of Urinary Stonesmentioning

confidence: 99%

The elementome of calcium-based urinary stones and its role in urolithiasis

et al. 2015

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Urolithiasis affects around 10% of the US population with an increasing rate of prevalence, recurrence and penetrance. The causes for the formation of most urinary calculi remain poorly understood, but obtaining the chemical composition of these stones might help identify key aspects of this process and new targets for treatment. The majority of urinary stones are composed of calcium that is complexed in a crystalline matrix with organic and inorganic components. Surprisingly, mitigation of urolithiasis risk by altering calcium homeostasis has not been very effective. Thus, studies to identify other therapeutic stone-specific targets, using proteomics, metabolomics and microscopy techniques, have been conducted, revealing a high level of complexity. The data suggest that numerous metals other than calcium and many nonmetals are present within calculi at measurable levels and several have distinct distribution patterns. Manipulation of the levels of some of these elemental components of calcium-based stones has resulted in clinically beneficial changes in stone chemistry and rate of stone formation. The elementome—the full spectrum of elemental content—of calcium-based urinary calculi is emerging as a new concept in stone research that continues to provide important insights for improved understanding and prevention of urinary stone disease.

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The action of excessive, inorganic silicon (Si) on the mineral metabolism of calcium (Ca) and magnesium (Mg)

Cited by 18 publications

References 11 publications

Systemic analysis of urinary stones from the Northern, Eastern, Central, Southern and Southwest China by a multi-center study

Systemic analysis of urinary stones from the Northern, Eastern, Central, Southern and Southwest China by a multi-center study

Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds

The elementome of calcium-based urinary stones and its role in urolithiasis

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