The action of Guillain-Barré syndrome serum on myelin

Myelination Inhibiting and Neuroelectric Blocking Factors in Experimental Allergic Encephalomyelitis

“…Other studies, however, have shown that most serums from animals with EAE induced by the encephalitogenic factor, a basic protein (BP) component of myelin (4), neither demyelinate (5) nor inhibit myelin formation (6) in CNS cultures, in spite of the presence of detectable levels of antibodies to BP. In studies with rabbits as test animals, evidence has been presented that antibodies to cerebroside may be the serum factors which cause demyelination and myelination inhibition in vitro (7). Cerebroside does not induce EAE (7), and the demonstration that cerebroside is the component of whole CNS which induces demyelinating and myelination inhibiting factors lends support to the concept that these factors are epiphenomena, not related to the pathogenesis of EAE (5,6).…”

“…In studies with rabbits as test animals, evidence has been presented that antibodies to cerebroside may be the serum factors which cause demyelination and myelination inhibition in vitro (7). Cerebroside does not induce EAE (7), and the demonstration that cerebroside is the component of whole CNS which induces demyelinating and myelination inhibiting factors lends support to the concept that these factors are epiphenomena, not related to the pathogenesis of EAE (5,6).…”

“…It is thought that these thesis of new discs nor the disposal of labeled amino acids are incorporated old discs, since radioactive label that into protein that is used in the assembly is incorporated into cone outer segof new rod discs at the outer segment ments does not accumulate in a distinct base (2). The labeled discs are con-band as it does in rods (7). Rather, tinuously displaced from the base to the labeled material is seen as diffusely the apex of the rod outer segment incorporated throughout the cone outer (1,3).…”

“…Electron photoreceptors of diurnal tree squirrels microscopic evidence confirms that in a process of disc shedding. We also groups of rod discs detach intermit-show that proteins in the conelike 14 MARCH 1975 outer segments are diffusely renewed like those in all other vertebrate cones examined (7). Cohen (9) described the fine structure of two photoreceptor classes in the retina of the Eastern grey squirrel (Sciurus carolinensis), an arboreal species whose retina had been thought to contain only cones (10).…”

Antibody Binding to PNS Myehn Proteins in Acute Guillain-Barré Syndrome

“…Guillain-Barri syndrome (GBS) is be lieved to result from an immune-mediated injury to the myelinating cells of the periph eral nervous system (PNS) [1][2][3][4][5][6][7][8][9][10]. However, the mechanism of this injury is still unde fined, as is the identity of the pertinent PNS myelin or Schwann cell antigen(s).…”