The Action of Morphine‐like Drugs on Impulse Transmission in Mammalian Nerve Fibres

Kosterlitz, H. W.; Wallis, David

doi:10.1111/j.1476-5381.1964.tb01704.x

Cited by 34 publications

(15 citation statements)

References 22 publications

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“…The apparatus, adapted from the multi-chamber apparatus first used by Konig (1962) and later by Kosterlitz & Wallis (1964), was demonstrated to the Physiological Society in 1965 (Kosterlitz & Wallis, 1966b Fig. 1).…”

Section: H Tv Kosterlitz G M Lees a Nd D J Wallismentioning

confidence: 99%

Resting and action potentials recorded by the sucrose‐gap method in the superior cervical ganglion of the rabbit

Kosterlitz¹,

Lees²,

Wallis³

1968

The Journal of Physiology

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SUMMARY1. Evoked ganglionic action potentials and drug-induced changes in resting potential were recorded by the sucrose-gap method. The height of the action potential was 10-20 mV.2. Since the amplitude of the P wave is inversely proportional to the external potassium concentration between 0 5 and 12 mm, the P wave is probably caused by a phase of increased permeability to K+.3. In the absence of an anticholinesterase, the depolarizing actions of choline and acetylcholine on the ganglion are almost equal, whereas acetylcholine is 2-3 times more potent than choline on the fibres of the internal carotid nerve. In the presence of eserine, acetylcholine induces a depolarization of the ganglion of up to 14 mV, while increase in [K+]o causes a depolarization of up to 55 mV.4. Although the post-ganglionic fibres in the distal pole of the ganglion are depolarized by drugs, for example, acetylcholine, they contribute little to drug-induced potential changes and probably little to evoked action potentials.5. The hyperpolarization which occurs after exposure of the ganglion to acetylcholine is not due to a phase of increased permeability to K+.

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Section: H Tv Kosterlitz G M Lees a Nd D J Wallismentioning

confidence: 99%

Resting and action potentials recorded by the sucrose‐gap method in the superior cervical ganglion of the rabbit

Kosterlitz¹,

Lees²,

Wallis³

1968

The Journal of Physiology

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“…This blockade is not achieved through interference with impulse conduction in nerve terminals (Kosterlitz & Wallis, 1964), nor by depression due to blockade of uptake of catecholamines into synaptic vesicles (Blosser & Catravas, 1974). The analgesic effects of morphine are suppressed by intracistemal administration of Ca (Kakunga, Kaneto & Nano, 1966), whilst the tissue Ca of rat brain is decreased by morphine (Cardenas & 0007-1188/80/060185-07 $01.00 Ross, 1975).…”

Section: Introductionmentioning

confidence: 99%

An Electrophysiological Analysis of the Effects of Morphine on the Calcium Dependence of Neuromuscular Transmission in the Mouse Vas Deferens

Bennett

Lavidis

1980

British J Pharmacology

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1 The effects of morphine on the Ca-dependence of the synaptic potential amplitude in the mouse vas deferens have been determined.2 The synaptic potential increased with a power factor of 2.4 for [Ca]. between 0.7 mm and 1.8 mm.Morphine (40 nM) decreased the synaptic potential, without altering the second power relationship between the synaptic potential and [Ca]0. 3 Morphine reversed the depression in the synaptic potential which develops during a short highfrequency (10 Hz) train of impulses to facilitation. Consequently the synaptic potential beyond the tenth impulse was unaffected by morphine. 4 Morphine did not alter the facilitation of the synaptic potential which develops during a short low-frequency (<2 Hz) train of impulses in normal [Ca]0. Consequently morphine decreased the synaptic potential for each impulse by about the same percentage amount. 5 Morphine increased the small facilitation in the synaptic potential which occurs during a short low-frequency (< 2 Hz) train of impulses in high [Ca]0. This facilitation approximated the predictions based on the assumption that each impulse leaves residual Ca ions bound to receptors involved in transmitter release from the nerve terminal.

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“…Non-myelinated fibres of nontryptaminergic neurones may not share this morphine sensitivity. For instance, Kosterlitz & Wallis (1964) found no effect of morphine on the C fibres of peripheral nerves, but they looked mainly for an inhibitory effect. If sensitivity to morphine is peculiar to fibres of tryptaminergic neurones, other effects of morphine, apart from analgesia, may well be accounted for by a synaptic action which may even apply to the analgesia produced by large doses of morphine on the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Analgesia Produced by Morphine When Acting From the Liquor Space

Dey

Feldberg

1976

British J Pharmacology

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In cats analgesia was produced by morphine sulphate introduced into different parts of the liquor space in doses too small to be effective on intravenous injection. Analgesia was measured with the tail pinch method of Russell & Tate (1975). On infusion into the fourth ventricle or into the subarachnoid space beneath the ventral surface of the brain stem caudal to the pons, doses of 100 to 200 μg of morphine sulphate were sufficient to produce strong long‐lasting analgesia. On injection into the cisterna magna somewhat larger doses (400 to 800 μg) were required. It is concluded that the site where morphine acts when producing analgesia in all three circumstances is at the ventral surface of the brain stem. The possibility is discussed that the structures acted upon are tryptaminergic nerve fibres. They arise from the raphe nuclei, belong to a descending inhibitory pathway, and on their way to the spinal cord, reach the ventral surface of the brain stem lateral to each pyramid, where they could be reached and acted upon by the morphine. This theory postulates a morphine sensitivity of tryptaminergic nerve fibres.

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The Action of Morphine‐like Drugs on Impulse Transmission in Mammalian Nerve Fibres

Cited by 34 publications

References 22 publications

Resting and action potentials recorded by the sucrose‐gap method in the superior cervical ganglion of the rabbit

Resting and action potentials recorded by the sucrose‐gap method in the superior cervical ganglion of the rabbit

An Electrophysiological Analysis of the Effects of Morphine on the Calcium Dependence of Neuromuscular Transmission in the Mouse Vas Deferens

Analgesia Produced by Morphine When Acting From the Liquor Space

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