The Action of Morphine on the Urinary Bladder of the Unanesthetized Dog: A Comparison with the Action of Parasympathomimetic Drugs

Winter, Irwin C.

doi:10.1016/s0022-5347(17)71064-6

Cited by 6 publications

(2 citation statements)

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“…There is some similarity between the action of morphine on micturition and on defacation; urinary retention and constipation usually occur simultaneously during opioid therapy. Although therapeutic doses of morphine may be spasmogenic on the large intestine and the dog bladder (Edmonds & Roth, 1920;Duzen et al, 1940;Winter, 1941) no similar effect was found on the rat bladder (Figure 4). The spasmogenic action of the opioids on other multiunit smooth muscles such as the gall bladder and the bronchioles, is probably not at all similar to their action on the large intestine.…”

Section: Discussionmentioning

confidence: 99%

“…Therapeutic doses ofopioids also cause urinary retention. Early studies attributed this effect on micturition to excitatory actions of the opioids on the sphincter muscle of the bladder (Czapek & Wassermann, 1914;Ikoma, 1924) and also on the detrusor muscle (Duzen et al, 1940;Winter, 1941). Either of these actions could be responsible for the impairment of voiding.…”

Section: Introductionmentioning

confidence: 99%

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Micturition in naive and morphine‐dependent rats

Carpenter

1986

British J Pharmacology

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1Voiding responses were recorded in conscious water-loaded rats. Morphine sulphate (5 mg kg I) elevated the volume threshold for micturition (MV); the group mean MV of 16 rats after morphine was 40% larger than control. Micturition was nevertheless complete since no urine remained in the bladder afterwards. 2 The implantation of2 or 4 morphine-base pellets (150 or 300 mg morphine) elevated for 12 days the MV in water-loaded rats. On the 3rd to the 10th day following implantation the group mean was approximately twice that ofuntreated controls. After micturition was over no residual urine was found in the bladder. 3 Within 3 days the rats became tolerant to the antinociceptive action of the morphine-base pellets but little apparent tolerance developed to their action on micturition. 4 On the 1st day after the pellets were removed, the mean MV was reduced. When withdrawal was precipitated by the administration of naloxone the MV was often too small to measure. This component of a withdrawal syndrome could be elicited in the rats throughout the 12 days of morphine pellet implantation. 5 The administration of 20 mg kg-' morphine sulphate to anaesthetized rats did not decrease the contractions of the urinary bladder to repetitive stimulation of its motor nerves at I and 20 Hz.

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Section: Discussionmentioning

confidence: 99%