The action of norepinephrine on the transport of fatty acids and triglycerides by the isolated perfused rat liver

Heimberg, Murray; Fizette, Norman B.

doi:10.1016/0006-2952(63)90067-4

Cited by 88 publications

(5 citation statements)

References 9 publications

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“…This increase is magnified by the addition of glucagon or HLS. The addition of both factors produced an additive ef- 13-17 24 20-27 15 10-24 23 15-28 This last effect was inhibited by the simultaneous addition of glucagon and HLS.…”

Section: Resultsmentioning

confidence: 84%

Effect of Glucagon on the Metabolism of Lipids and on Urea Formation by the Perfused Rat Liver

Penhos

Daunas

et al. 1966

Diabetes

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Livers obtained from fed or fasted rats were perfused with blood from fasted rats with and without the addition of glucagon and/or a hyperlipemic serum (HLS).In addition to its well-known hyperglycemic effect, glucagon increased the blood levels of the ketone bodies and of urea, and decreased the levels of cholesterol, total lipids and NEFA.The magnitude of the effects noted were dependent upon the previous state of the liver and the addition of the hyperlipemic serum.In the fed liver, glucagon produced a greater degree of hyperglycemia than in the fasted liver and this effect was enhanced by the addition of a hyperlipemic serum. In fasted livers the addition of a hyperlipemic serum did not increase the hyperglycemia produced by glucagon alone.Total lipids, cholesterol and NEFA were decreased when glucagon was added to either the fasted or fed liver, in the presence or absence of a hyperlipemic serum.Glucagon caused a greater increase in the level of ketone bodies in the fasted than in the fed liver and this effect was increased by the addition of a serum rich in lipids.The addition of glucagon caused an increase in the levels of urea and this effect was reduced when a hyperlipemic scrum was acMted. DIABETES 15:74048, October, 1966. A survey of the available literature on the effects of glucagon on various aspects of lipid metabolism discloses unexplained discrepancies in the results. On the one hand it has been reported that glucagon is lipolytic and in the main inhibits the synthesis of fat and cholesterol. 5 ' 21 ' 22 ' 36 ' 43 ' 52 On the other hand there also exist data to show that glucagon lowers the concentration of fatty acids in the plasma and increases fat synthesis. 1 -14 ' 43 In the case of ketone body metabolism,

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Section: Resultsmentioning

confidence: 84%

Effect of Glucagon on the Metabolism of Lipids and on Urea Formation by the Perfused Rat Liver

Penhos

Daunas

et al. 1966

Diabetes

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“…The uptake of FFA by the liver is not altered by glucagon or dBcAMP (HEIMBERG et aI., 1969) and is only slightly reduced by noradrenaline (HEIMBERG and FIZETTE, 1963); the latter effect was observed in the presence of phenoxybenzamine which may have modified somewhat the metabolic effect of the noradrenaline. In contrast to the lack of effect on uptake, noradrenaline (HEIMBERG and FIZETTE, 1963), glucagon (HEIMBERG et aI., 1969;PENHOS et aI., 1966) and dBcAMP (HEIMBERG et aI., 1969) markedly inhibit the secretion of triglyceride by the liver. The biochemical basis for this inhibition of lipid secretion is not understood.…”

Section: E) Lipid Metabolismmentioning

confidence: 95%

Effects of Catecholamines on Metabolism

Himms‐Hagen¹

1972

Catecholamines

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“…In contrast with the hormones mentioned above, however, very little is known about the direct effects of catecholamines on hepatic triacylglycerol metabolism. Previous studies in vitro were conducted on the perfused rat liver (Heimberg & Fizette, 1963;Heimberg et al, 1964). These experiments were complicated by the effects of the catecholamines on liver vasculature, which necessitated inclusion of an a-adrenergic antagonist in the perfusate.…”

Section: Introductionmentioning

confidence: 99%

α-adrenergic suppression of very-low-density-lipoprotein triacylglycerol secretion by isolated rat hepatocytes

Brindle

Ontko

1988

Biochemical Journal

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The effect of adrenaline on triacylglycerol synthesis and secretion was examined in isolated rat hepatocytes. Cells were incubated with 0.5 mM-[1-14C]oleate, and the accumulation of triacylglycerol and [14C]triacylglycerol was measured in the incubation medium. Triacylglycerol appearing in the medium was present in a form with properties similar to very-low-density lipoproteins. Triacylglycerol, [14C]triacylglycerol and [14C]phospholipid contents of hepatocytes were also determined. Addition of 10 microM-(-)adrenaline decreased accumulation of glycerolipid in the incubation medium and also decreased cellular [14C]phospholipid content. Prazosin abolished these effects, whereas propranolol did not. The hormone did not affect cellular triacylglycerol content or rates of incorporation of [1-14C]oleate into cell triacylglycerol. The effect of adrenaline on the removal of newly secreted triacylglycerol and the secretion of synthesized glycerolipid was also examined. The catecholamine did not affect rates of removal of newly secreted triacylglycerol. Adrenaline did inhibit the secretion of pre-synthesized lipid by the cells, as assessed by the appearance of radiolabelled triacylglycerol from hepatocytes that had been preincubated with [1,2,3-3H]-glycerol. Adrenaline did not affect rates of fatty acid uptake by hepatocytes, but did stimulate oxidation of [1-14C]oleate, principally to 14CO2.

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The action of norepinephrine on the transport of fatty acids and triglycerides by the isolated perfused rat liver

Cited by 88 publications

References 9 publications

Effect of Glucagon on the Metabolism of Lipids and on Urea Formation by the Perfused Rat Liver

Effect of Glucagon on the Metabolism of Lipids and on Urea Formation by the Perfused Rat Liver

Effects of Catecholamines on Metabolism

α-adrenergic suppression of very-low-density-lipoprotein triacylglycerol secretion by isolated rat hepatocytes

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