The action of "peptone" on blood and immunity thereto

doi:10.1098/rspb.1922.0026

Proc. R. Soc. Lond. B.

1922

DOI: 10.1098/rspb.1922.0026

|View full text |Cite

The action of "peptone" on blood and immunity thereto

Abstract: The current view on the cause of the non-coagulability of the blood after the injection of “peptone” is that the injected material stimulates the liver (or the liver plus other organs) to form an excess of a substance named antithrombin. The liver is considered further to form antithrombin under normal conditions in amount sufficient to maintain the fluidity of the blood. The statement that “peptone” which follows its slow injection is commonly ascribed to hepatic activity. The experiments recorded in this pap… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1924

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The action of “peptone” and of nucleic acids on the coagulability of the blood

Pickering¹,

Hewitt²

1924

Proc. R. Soc. Lond. B.

View full text Add to dashboard Cite

In a previous communication to this Society, tbe present authors showed that the rapid intravascular injection of " peptone " into cats, deprived of hepatic activity, inhibited coagulation of the blood. It was also shown that when precautions are taken to preserve the surface conditions of the blood of the cat, pronounced retardation of clotting can be obtained in vitro by the addition of " peptone " in quantities no greater than are required to produce a like effect in vivo (Pickering and Hewitt, 1). Subsequently, Nolf (2) observed that the anti-coagulant action of " peptone " on the blood of the domestic fowl, with the liver extirpated, is actually greater than in the intact animal. Experimenting with the blood of dogs, Doyon (3) found that nucleic acid, prepared by Neumann's method (4) from the thymus and from the mesenteric ganglia of the ox, is anticoagulant in vivo and in vitro, the former reaction being ascribed to the supposed secretion, by the liver, of an antithrombic nucleoprotein.In this paper the action of W itte's peptone on the coagulability of the blood of the tortoise, rat and dog, and that of thymus and yeast nucleic acids, is described and discussed. In each experiment, except where otherwise stated, the blood was obtained from animals with the liver out of circulation. I . -Technique and Terms Employed.The mammals used were anaesthetised with A.C.E., pithed, and artificial respiration was employed for at least 10 minutes prior to injection of either peptone " or of nucleic acid. The tortoises were anaesthetised with chloroorin aud decapitated after clamping the vessels of the neck. The mammals ^ere deprived of hepatic activity by ligature of the thoracic aorta and inferior Veua cava> the tortoises by ligature of the bulbus arteriosus and sinus venosus.Blood was shed through evenly paraffined cannulae into clean glass vessels, m quantities of 1 c.c. or less at a time, as blood shed in small quantities does Uot exhibit the hyper-coagulability which arises from excessive haemorrhage.on May 9, 2018 http://rspb.royalsocietypublishing.org/ Downloaded from

show abstract

The action of “peptone” and of nucleic acids on the coagulability of the blood

Pickering¹,

Hewitt²

1924

Proc. R. Soc. Lond. B.

View full text Add to dashboard Cite

show abstract

Blood coagulation, anti-coagulants and hæmolysis

1924

Proc. R. Soc. Lond. B.

View full text Add to dashboard Cite

Attention has recently been directed to the action of certain substances both in inhibiting the spontaneous clotting of blood and in affording protection against hæmolysis (Pickering and de Souza, 1). No systematic enquiry appears, however, to have been made into the possible influence of anticoagulants on the lysis of erythrocytes. We have found that most substances which restrain the clotting of blood are also anti-hæmolytic against heterologous sera, a specific hæmolysin, and cobra venom; also that certain agencies which restore the coagulability of blood after the influence of anti-coagulants will neutralise the anti-hæmolytic action of these substances.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The action of "peptone" on blood and immunity thereto

Cited by 2 publications

References 8 publications

The action of “peptone” and of nucleic acids on the coagulability of the blood

The action of “peptone” and of nucleic acids on the coagulability of the blood

Blood coagulation, anti-coagulants and hæmolysis

Contact Info

Product

Resources

About