The Action of Porcine Glucagon on the Motility of the Canine Duodenum and Jejunum

Abstract

Intravenous bolus doses of porcine glucagon of 0.001 −0.05 mg kg−1 caused intense stimulation of the duodenum and jejunum of the dog. Intravenous infusion of porcine glucagon at 0.025 −0.05 mg kg−1 h−1 caused similar stimulation. In both cases the stimulation was phasic in nature. Stimulation of the duodenum and jejunum following glucagon was accompanied by a decrease in frequency of the intestinal basic electrical rhythm (BER). No change was seen in the intervals between successive periods of phase III motor activity.