The action of sex hormones on endometrial secretion in spayed rats sensitized to oestradiol

Meglioli, G.; Krähenbühl, C.; Desaulles, P. A.

doi:10.1007/bf01899120

Cited by 6 publications

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“…Armstrong (1968), using a multiple puncture, blotting and reweighing technique to measure the uterine luminal fluid volume of oestrogen-treated spayed rats, reported ligation of the uterine horns at the cervical ends prevented the fluid loss and therefore concluded that progesterone opens the cervical canals. Meglioli, Krahenbuhl & Desaulles (1969) studied, by an aspiration and reweighing technique, oestrogen-treated spayed rats in which the distal ends of the uterine horns had been closed by electrocautery. Progesterone was reported to decrease the volume and increase the viscosity of the uterine luminal fluid even while oestrogen treatment continued, indicating the reabsorption of uterine luminal fluid after progesterone treatment.…”

Section: Introductionmentioning

confidence: 99%

Secretion and reabsorption of uterine luminal fluid in rats

Clemetson¹,

Verma²,

Carlo³

1977

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Section: Introductionmentioning

confidence: 99%

Secretion and reabsorption of uterine luminal fluid in rats

Clemetson¹,

Verma²,

Carlo³

1977

Reproduction

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“…The capacity of progesterone to reduce the quantity and simultaneously increase the viscosity of the uterine secretion in normal and castrated rats [Armstrong, 1968;Meglioli et al" 1969] was also evident in hypophysectomized animals. The reduction in secretion in both groups was parallel to the reduction in uterine weight and proportional to the doses.…”

Section: Discussionmentioning

confidence: 88%

The Role of the Pituitary in Modifications of the Uterine Secretion of Spayed, Oestradiol-Primed Rats

Meglioli

Desaulles

1973

Horm Res

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Tests performed on spayed, oestradiol-primed rats with ligated uteri and normal pituitary function have shown that treatment with sexual steroids modifies uterine secretion. Progesterone elicits a decrease in the quantity and an increase in the viscosity of the uterine secretion, an effect also produced by testosterone at very high dose levels. A decrease in the pH of the secretion was also observed. Supplementary oestradiol treatment was devoid of any activity.This paper describes the results obtained when the same experiment was carried out in normal castrate and castrate-hypophysectomized rats. The effects of varying subcutaneous doses of progesterone, testosterone, and oestradiol were compared. In both groups, a number of rats primed with oestradiol only served as controls.Progesterone induced a dose-dependent reduction in the weight of the uterus and in the quantity and pH of the uterine secretion, as well as a marked increase in its viscosity, in both intact and hypophysectomized rats.Testosterone increased the weight of the uterus and, when given in large doses, reduced the pH of both the lumen and secretion. The quantity of the uterine secretion diminished in response to high doses and its viscosity increased markedly only in rats bearing a pituitary.Oestradiol did not elicit significant changes in either group; a slight reduction in the pH of the uterine secretion was observed in response to high doses.It may be concluded that the progestative modifications induced by progesterone in the uterus of spayed, oestradiol-primed rats, including particularly changes in uterine secretion, are the effects of a peripheral mechanism not involving the pituitary. Testosterone appears to be an exception as far as the quantity and viscosity of uterine secretion are concerned, since modifications in these parameters are only observed in the presence of a functional pituitary body.

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“…The pH of the uterine lumen and the pH and viscosity of the uterine secretion were measured by the techniques described by Meglioli et al (1969 tí-*f rn es oo oo ob ob …”

Section: Methodsmentioning

confidence: 99%

“…This secretion may be attributable to the secretion of oestrogens by the ovaries, since fluid accumulates in the closed uteri of spayed rats treated with oestradiol (Ringler, 1961¡Armstrong, 1968Meglioli, Krähenbühl & Desaulles, 1969). Most workers have used oestradiol to demonstrate this activity, and little has been published about the sensitivity of the secretory response of the endometrium to other oestrogens.…”

Section: Introductionmentioning

confidence: 92%

Oestrogenic sensitivity of rat uterine secretion

Meglioli¹

1976

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Ovariectomized adult rats with closed uteri were treated for 7 days with different oral and s..c. doses of oestradiol, oestrone, oestriol and ethinyl oestradiol. All treatments elicited the production of uterine fluid and the potencies of oestrogens were related to the amount of fluid secreted. Ethinyl oestradiol and oestradiol displayed similar activity when given s.c. A daily dose of 0-003 mg oestradiol/kg resulted in about 700 mg fluid. Oestrone was 3-10 times and oestriol about 100 times less active. Orally, ethinyl oestradiol was the most potent substance and 700 mg secretion was obtained with a dose of 0-03 mg/kg daily. Oestradiol was about 30 times, oestrone about 100 times and oestriol 50 times less active than ethinyl oestradiol by this route. The viscosity of the secretion was unaffected, remaining between 1-6 and 2-4 cP. The pH of the fluid did not change, but that of the uterine lumen diminished slightly. These effects of oestrogens were associated with an increase in the weight of the empty uterus and a decrease in body weight.

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The action of sex hormones on endometrial secretion in spayed rats sensitized to oestradiol

Cited by 6 publications

References 0 publications

Secretion and reabsorption of uterine luminal fluid in rats

Secretion and reabsorption of uterine luminal fluid in rats

The Role of the Pituitary in Modifications of the Uterine Secretion of Spayed, Oestradiol-Primed Rats

Oestrogenic sensitivity of rat uterine secretion

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