The Action of Some Nucleotoxic Substances on Pregnancy

Abstract

In a previous investigation (Didcock, Picard, and Robson, 1952) it was shown that podophyllotoxin, which is a nucleotoxic substance with striking inhibitory effects on certain tumours, will interrupt pregnancy in mice and rabbits. The relation between the dose necessary to affect pregnancy and that toxic and lethal to the mother-what might be called in this connexion the therapeutic ratio-was, however, low, being of the order of 4. It was of interest to investigate the effect of other nucleotoxic substances on pregnancy, to determine whether there is any relation between nucleotoxic activity and effect on pregnancy, and also whether there are any nucleotoxic substances with a higher therapeutic ratio than podophyllotoxin. METHODSThe experiments were performed on mice and rabbits. In the former the duration of pregnancy was dated from the finding of the vaginal plug, and in the latter from the observed mating. In mice injected between the sixth and tenth days of pregnancy a laparotomy was performed to establish that a normal pregnancy was present. After this time it is possible to confirm the existence of pregnancy by abdominal palpation. Before the sixth day, when implantation occurs, the effect of the drug was established by dividing a number of mice, in which vaginal plugs had been found, into two groups. One group was treated and the other served as control.The intra-amniotic and intraplacental injections were performed on rabbits under ether anaesthesia with full sterile precautions.

The Action of Furazolidone on Pregnancy

“…However, the foetus was much more sensitive at the time of implantation (7th-8th day) when 90 % foetal deaths were produced. A similar effect in mice was found by Didcock et al [1956]. These workers also found that the anti-metabolites D-glucosamine and 4-amino-iVri0-methyl pteroyl glutamic acid were almost completely inactive when given to mice between the 11th and 13th days of pregnancy.…”

“…The experiments were performed on mice (albino C strain) and rabbits, using the methods described by Didcock et al [1956]. In mice the duration of pregnancy was dated from the finding of the vaginal plug and in rabbits from the observed mating.…”

“…Didcock, Jackson & Robson [1956] have shown that a number of cytotoxic drugs can affect pregnancy, and it was thought of interest to investigate whether furazolidone has an effect on gestation, since at this time there is rapid new growth in the body.…”

Topical antiviral and antifungal medications in pregnancy: a review of safety profiles

“…In animal studies, daily topical use for 13 days of doses up to five times MRHD did not result in teratogenicity . At approximately 19 times MRHD, skeletal abnormalities are noted . Human studies are lacking.…”

Chemical Mutagens

“…Linkage map, 11 Lipopolysaccharide, 274, 280 Litter size, 547, 554 Liver, [89][90][91]94,99,108,122,140,418 poison,577 LSD,575 Lung,94 Lymphocyte,380,[525][526][527]416,420,421 Ly~~ 12~ 15~ 175,196,197,229,291 immunity to,238 Lysogeny,21,20,122,152,196,197,231 Macrophage,401,402 Magdala red,293,305 Magnesium acetate,123 Magnesium ions,123 Magnesium sulfate,208 Maize, see Corn MAK, see Methylated serum albumin kieselguhr column Malate dehydrogenase, 603 lix Maleic hydrazide (MH), 45,61,359,360,378,493,494,495,498,560 MAM,…”