The action of thiethylperazihe torecan®), a new anti-emetic, compared with perphenazine (trilafon®), trmethobenzamide (tigan®), and a placeeio in the; suppression of postanaesthetic nausea and vomiting

Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review

“…Perphenazine was given intramuscular(ly) (i.m. ), 21,23,24,31 orally (p.o.) 26 or intravenous(ly) (i.v.).…”

“…22,25,27 -30 The application time was either at the time of the sedating premedication on the ward, 21,22,26 close to the induction of anaesthesia 25,[27][28][29][30] or concomitant with the extubation. 23,24,31 Efficacy of perphenazine was tested in adults having a cholecystectomy or gynaecological surgery and in children undergoing tonsillectomy. All studies with one 29 exception evaluated the efficacy of perphenazine Perphenazine to prevent postoperative nausea and vomiting 1045 versus at least one active control, but only two drugs, namely granisetron 26,27 and metoclopramide, 22,23,25,31 were tested twice or more as the control intervention.…”

“…The dose of perphenazine in adults varied between a fixed dose of 2.5 21 or 5 mg, 22,23,25,31 or a variable dose of 0.11 mg kg À1 , 24 whereas in children, always a body weight-adjusted dose of 0.07 mg kg À1 was investigated. Perphenazine was given intramuscular(ly) (i.m.…”

“…All studies with one 29 exception evaluated the efficacy of perphenazine Perphenazine to prevent postoperative nausea and vomiting 1045 versus at least one active control, but only two drugs, namely granisetron 26,27 and metoclopramide, 22,23,25,31 were tested twice or more as the control intervention. Four trials [21][22][23][24] in adults tested the efficacy of perphenazine versus placebo as a subgroup, whereas one study 29 in children exclusively investigated the antiemetic efficacy versus an inactive control.…”

“…[9][10][11][12][13][14][15][16][17][18][19][20] Eleven randomised, controlled trials (six trials in adults and five trials in children), published between 1965 and 1999, were finally included in the review (Tables 2 and 3). 18,[21][22][23][24][25][26][27][28][29][30] The data of 2081 participants (805 patients received perphenazine and 1276 received another drug or placebo as control) could be analysed. Sex distributionif available from the published trials -showed a larger proportion of women being studied (1368 women and 239 men were investigated).…”