The Action of Tumours on Their Hosts

Liquid chromatography/tandem triple‐quadrupole mass spectrometry for determination of paclitaxel in rat tissues

“…[2][3][4] Therefore, PTX is formulated for clinical use (Taxol, Bristol-Myers Squibb Inc., Princeton, NJ, USA) at a concentration of 6 mg/mL in a mixture containing 50% (v/v) of the organic solvent ethanol plus the surfactant polyethoxylated castor oil (Cremophor EL). The ethanol/Cremophor vehicle which is required to solubilize paclitaxel is toxic and has been observed to cause life-threatening anaphylactoid reactions.…”

“…Paclitaxel (PTX) is a natural component extracted from the bark of the yew tree, and now it can be semi‐synthesized as an important antineoplastic agent that is a treatment for ovarian cancer, breast cancer and non‐small‐cell lung cancer 1. PTX is poorly soluble, not only in water, but also in the oils and surfactants commonly used to prepare emulsions or other formulations 2–4. Therefore, PTX is formulated for clinical use (Taxol, Bristol‐Myers Squibb Inc., Princeton, NJ, USA) at a concentration of 6 mg/mL in a mixture containing 50% (v/v) of the organic solvent ethanol plus the surfactant polyethoxylated castor oil (Cremophor EL).…”