The Actions of Exogenous Dehydroepiandrosterone in Experimental Animals and Humans

Švec, František; Porter, Johnny R.

doi:10.3181/00379727-218-44285

Cited by 150 publications

(95 citation statements)

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“…The average serum DHEAS level in healthy "younger" adults is ϳ7.5 M, and increases to 20 -70 M following administration of pharmacological dosages of DHEA without any sign of systemic toxicity (33). These high levels of recirculating DHEAS can be converted to DHEA by ubiquitous steroid sulfatase.…”

Section: Discussionmentioning

confidence: 99%

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice

Khalil

Subramaniam

2001

The Journal of Immunology

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Experimental allergic encephalomyelitis (EAE) is a Th1-mediated inflammatory demyelinating disease in the CNS, an animal model of multiple sclerosis. We have examined the effect of dehydroepiandrosterone (DHEA) on the development of EAE in mice. The addition of DHEA to cultures of myelin basic protein-primed splenocytes resulted in a significant decrease in T cell proliferation and secretion of (pro)inflammatory cytokines (IFN-γ, IL-12 p40, and TNF-α) and NO in response to myelin basic protein. These effects were associated with a decrease in activation and translocation of NF-κB. In vivo administration of DHEA significantly reduced the severity and incidence of acute EAE, along with a decrease in demyelination/inflammation and expressions of (pro)inflammatory cytokines in the CNS. These studies suggest that DHEA has potent anti-inflammatory properties, which at least are in part mediated by its inhibition of NF-κB activation.

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Section: Discussionmentioning

confidence: 99%

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice

Khalil

Subramaniam

2001

The Journal of Immunology

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“…Thus, DHEAS has been studied with controversial results in several processes that occur during aging (10,11). In particular with reference to the mortality issue studied in this paper, we note that DHEAS has been inversely related to cardiovascular diseases in men (12)(13)(14)(15)(16), but this relation was not found in women (17).…”

mentioning

confidence: 99%

Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality

Mazat

Lafont

Berr

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

149

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The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agé es) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in women, a decrease with age and, among men, a negative correlation between the DHEAS level and mortality at 2 and 4 years. Here, with an 8-year followup in 290 subjects, we show a global decrease of 2.3% per year for men and 3.9% per year for women. However, in approximately 30% of cases, there was an increase of DHEAS. We observed no relationship between the evolution of DHEAS level and functional, psychological, and mental status, possibly because of selection by death. In women, no association was found between mortality and DHEAS level. In men, the relative risk (RR) of death was higher for the lowest levels of DHEAS (RR ‫؍‬ 1.9, P ‫؍‬ 0.007), with RR ‫؍‬ 6.5, P ‫؍‬ 0.003 for those under 70 years old, a result indicating heterogeneity of the population. There was an effect of subjective health on mortality that disappeared after adjustment of DHEAS levels, suggesting its relation with these DHEAS levels. Death RR was much higher in smokers with a low DHEAS level than in nonsmokers with high DHEAS (RR ‫؍‬ 6.7, P ‫؍‬ 0.001). We submit that the involvement of DHEAS is possibly different according to gender, that association between low DHEAS level and mortality only for men under 70 years old possibly reflects heterogeneity of the population, and that DHEAS level is a reliable predictor of death in male smokers. I n human beings, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are secreted adrenal steroids whose role is still poorly understood. Except in the nervous system, no receptor for those steroids has been described, and they likely operate in part by a transformation into androgens and estrogens (1-5) and probably also directly as neuroactive steroids (6). Furthermore, DHEAS concentration declines with age (7, 8) and remains 10-20% higher in men than in women (9), despite an important interindividual range.The decline of DHEAS concentrations with aging has led to the suggestion that DHEAS could play a role in itself and be implicated in longevity. Thus, DHEAS has been studied with controversial results in several processes that occur during aging (10, 11). In particular with reference to the mortality issue studied in this paper, we note that DHEAS has been inversely related to cardiovascular diseases in men (12-16), but this relation was not found in women (17).To clarify the role of DHEAS, our strategy within the PAQUID ʈ program (a prospective cohort study of elderly subjects from the southwest of France) was to relate DHEAS level with several health parameters and mortality. Among the 3,777 elderly subjects of this cohort, 622 volunteers agreed to have blood sampling after 1 year of followup. The measurement of DHEAS concentrations at this time allowed us to confirm the already known ...

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“…It is well known that age-related decreases in DHEA are associated with increases in obesity and a decline in fat free mass (Morales et al 1998) yet the potential usefulness of DHEA as a slimming agent is mostly indicated by previous research in animals, particularly lower mammals (Cleary 1991). In the rat plasma concentration of DHEA ranges between 14 and 80 nM while in the plasma of humans DHEA-concentration ranges between 5 and 24 nM and DHEAS-concentration is up to 9 μM (Svec & Porter 1998). The anti-obesity effect of DHEA in animals could be due to several possible mechanisms (Cleary 1991;Ebeling & Koivisto 1994;Kroboth et al 1999).…”

Section: Fat Mass Alteration and Steroid Prohormones Intakementioning

confidence: 99%

Steroid Prohormones: Effects on Body Composition in Athletes

Ostojić¹,

González²,

Stojanović³

2011

Steroids - Clinical Aspect

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The Actions of Exogenous Dehydroepiandrosterone in Experimental Animals and Humans

Cited by 150 publications

References 0 publications

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice

Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality

Steroid Prohormones: Effects on Body Composition in Athletes

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