The Activating Effect of Histamine On The Central Nervous System

Monnier, M; Sauer, Robert M.; Hatt, Alice

doi:10.1016/s0074-7742(08)60064-1

Cited by 85 publications

(18 citation statements)

References 48 publications

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“…Early studies emphasized the role of the central reticular activating system; later, a histaminergic hypothalamic arousal system was described, [113] and a noradrenergic arousal/ alerting pathway from the locus coeruleus has been proposed [114]. Recently, the hypocretin/orexin pathways from the lateral hypothalamus to many brain stem and forebrain structures [115] have been reported to play an important role in the maintenance of alertness.…”

Section: Regulation Of Central Arousal Mechanisms; Sedation and Anestmentioning

confidence: 99%

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Pharmacology of Opioid Drugs

Cox¹

2010

The Opiate Receptors

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Extracts of the opium poppy have been used for the relief of pain since antiquity. The active principle, morphine, continues to this day to be one of the most effective ways of alleviating moderate and severe pain. It is also one of the most addicting drugs known to man. This chapter describes the history of research on opium and the pharmacologic properties of morphine and related drugs. It briefly summarizes critical studies in the development of current knowledge of their antinociceptive actions; their effects on arousal, respiration, locomotor activity, and behavioral reinforcement; endocrine effects; and actions on peripheral tissues including the gastrointestinal tract, the genital tract, and the heart and circulatory system. The last section provides an overview of the absorption, metabolism, and distribution of morphine and other major opiate drugs.

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Section: Regulation Of Central Arousal Mechanisms; Sedation and Anestmentioning

confidence: 99%

“…Firing rates are increased, and there is increased hypocretin mRNA expression [123]. The mechanism of arousal by the hypocretic-orexin system appears to require the participation of histamine [122]; the hypothalamic histaminergic system [113] is activated by the local release of hypocretin.…”

Section: Regulation Of Central Arousal Mechanisms; Sedation and Anestmentioning

confidence: 99%

Pharmacology of Opioid Drugs

Cox¹

2010

The Opiate Receptors

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“…When Hi is given either systemically or is injected directly into the brain it produces alterations in cat [5] and rat [6][7][8][9] behaviour. In previous experiments [9][10][11] it has been shown that Hi exerts a suppressive influence on rat locomotion, producing hypokinesia or akinesia.…”

Section: Introductionmentioning

confidence: 99%

Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum

Nowak

Maśliński

1977

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Administration of 500 microng of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histamine-mediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug - mepyramine. Moreover atropine significantly reduced the histamine-induced increase of HVA. It is concluded that histamine primarily activates cholinergic neurons and that the changes in DA metabolism are a consequence of an increased cholinergic activity.

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“…This implies the presence of two cortical activating systems. The important neurotransmitters involved in maintaining wakefulness are acetylcholine, glutamate, norepinephrine, and histamine [1,[8][9][10]. Other peptides that are important in enhancing the effect of these neurotransmitters are vasoactive intestinal peptide, substance P, and neurotensin [1].…”

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confidence: 99%