2019
DOI: 10.1186/s12858-019-0105-4
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The active role of the transcription factor Sp1 in NFATc2-mediated gene regulation in pancreatic cancer

Abstract: BackgroundAdenocarcinoma of the pancreas is one of the most aggressive tumor diseases affecting the human body. The oncogenic potential of pancreatic cancer is mainly characterized by extremely rapid growth triggered by the activation of oncogenic signaling cascades, which suggests a change in the regulation of important transcription factors. Amongst others, NFAT transcription factors are assumed to play a central role in the carcinogenesis of pancreatic cancer. Recent research has shown the importance of the… Show more

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Cited by 19 publications
(14 citation statements)
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“…Pancreatic cancer is a common malignant tumor of the digestive tract. Due to its di culty in early detection and easy metastasis and recurrence, it is the main reason for poor quality of life and short survival of pancreatic cancer patients.This requires us to conduct in-depth research on the occurrence and development of pancreatic cancer, especially on the genes and proteins that play a key role in the pathogenesis and treatment of pancreatic cancer.With the maturity of genomics, transcriptomics and high-throughput sequencing technology and the improvement of bioinformatics database, we can explore the occurrence and development of pancreatic cancer from the direction of basic research.AMIGO is a novel sequence induced by amphoteric proteins promoted by neurites.AMIGO1, AMIGO2 and AMIGO3 together constitute a new gene family, encoding type I transmembrane proteins and containing six leucine-rich repeats (LRR) [27] .Studies have shown that genes with LRR domain can induce the proliferation, migration and metastasis of a variety of tumors.In addition, the AMIGOS family showed two conserved serine-rich regions;One is near the transmembrane domain and the other is at the end of the COOH.The COOH-terminal serine-rich region of AMIGO2 has a common sequence of casein kinase II serine/threonine kinase [28] .The transmembrane form of TNF-α has a common SXXS sequence, which is the substrate for casein kinase I-dependent phosphorylation [28] .AMIGO2 has four possible casein kinase I phosphorylation sites in both of these conserved serine-rich regions [27] .This suggests that AMIGO2 may bind to TNF-α.TNFα involved in the signaling pathway has been shown to play an important role in pancreatic tumors [29][30][31] .In addition, AMIGO2 is involved in the process of collagen adhesion and migration of gastric cancer cells [15] .AMIGO2 also mediates the adhesion of tumor cells to hepatic endothelial cells and promotes the metastasis of hepatoma cells in the liver [32] .These evidences indicate that AMIGO2 has the structural characteristics of participating in the proliferation, invasion, migration and distant metastasis of various malignant tumors, and plays an important role in the metastasis of liver cancer and gastric cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Pancreatic cancer is a common malignant tumor of the digestive tract. Due to its di culty in early detection and easy metastasis and recurrence, it is the main reason for poor quality of life and short survival of pancreatic cancer patients.This requires us to conduct in-depth research on the occurrence and development of pancreatic cancer, especially on the genes and proteins that play a key role in the pathogenesis and treatment of pancreatic cancer.With the maturity of genomics, transcriptomics and high-throughput sequencing technology and the improvement of bioinformatics database, we can explore the occurrence and development of pancreatic cancer from the direction of basic research.AMIGO is a novel sequence induced by amphoteric proteins promoted by neurites.AMIGO1, AMIGO2 and AMIGO3 together constitute a new gene family, encoding type I transmembrane proteins and containing six leucine-rich repeats (LRR) [27] .Studies have shown that genes with LRR domain can induce the proliferation, migration and metastasis of a variety of tumors.In addition, the AMIGOS family showed two conserved serine-rich regions;One is near the transmembrane domain and the other is at the end of the COOH.The COOH-terminal serine-rich region of AMIGO2 has a common sequence of casein kinase II serine/threonine kinase [28] .The transmembrane form of TNF-α has a common SXXS sequence, which is the substrate for casein kinase I-dependent phosphorylation [28] .AMIGO2 has four possible casein kinase I phosphorylation sites in both of these conserved serine-rich regions [27] .This suggests that AMIGO2 may bind to TNF-α.TNFα involved in the signaling pathway has been shown to play an important role in pancreatic tumors [29][30][31] .In addition, AMIGO2 is involved in the process of collagen adhesion and migration of gastric cancer cells [15] .AMIGO2 also mediates the adhesion of tumor cells to hepatic endothelial cells and promotes the metastasis of hepatoma cells in the liver [32] .These evidences indicate that AMIGO2 has the structural characteristics of participating in the proliferation, invasion, migration and distant metastasis of various malignant tumors, and plays an important role in the metastasis of liver cancer and gastric cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Although members of SP TFs are critical for development, there is accumulating evidence that these proteins are overexpressed in various types of cancers. [ 11,27–29 ] The major structural difference between SP1 and SP3 is the location of the inhibitory domain. Whereas Sp1 has the inhibitory domain at the N‐terminus, the Sp3 inhibitory domain is located immediately in front of the DNA‐binding domain.…”
Section: Discussionmentioning
confidence: 99%
“…19 For instance, transcription factor Sp1 has a carcinogenic effect in pancreatic cancer. 20 Yin Yang-1 (YY1) is a zinc finger transcription factor that ubiquitously expressed in many tissues. 21 YY1 is well-known for its role in transcription regulation, which means it can regulate gene transcription to promote the development and progression of human cancers.…”
Section: Discussionmentioning
confidence: 99%