The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts

Abstract

CoCl 2 introduction increased cathepsin G activity in the heart and liver as well as endothelial elastase (EEl) in kidney that indicated the development of destructive processes. CoCl 2 introduction decreased EEl and cathepsin G activities in blood serum and cathepsin G in lungs. HgCl 2 injection decreased EEl in blood serum, heart, liver, kidney and cathepsin G in blood serum. These decreasing of proteinases activities may be caused by cytotoxic effects of heavy metals and/or the inclusion of these proteases in the destructive processes and absence of their synthesis and/or release.