The Activity of Alkaline Phosphatase in the Sera of DBA/2NCrj and CBA/BrA Mice with Calcified Tongue Lesions

Abstract

Spontaneously occurring calcified lesions were found in the tongues of DBA/2NCrj and CBA/BrA mice. In the DBA/2NCrj strain, the frequency of the lesion was 80% (males) and 88% (females). The youngest age of a mouse with this lesion was 18 days after birth, and 3-4 lesions were found in the tongue of 6-to 8-week-old mice. In CBA/BrA mice, 20% of females and 48% of males had the lesions. No significant differences were found in the serum calcium concentrations in high and low lesiondeveloping strains, but the alkaline phosphatase activities in the high-developing DBA/ 2NCrj, DBA/LiA, and CBA/BrA strains were higher than in strains with no calcified lesions.

Identification of a DBA/2 Mouse Sub-strain as a Model for Pseudoxanthoma Elasticum-Like Tissue Calcification

“…This result is supported by the fact that alkaline phosphatase activity in mouse strains that develop calcification is higher than that in strains resistant to calcification. 39) Thus, combined effects of multiple genes would contribute to the incidence and extent of calcification. Taking into account that expression level of Abcc6 gene in DBA/2CrSlc mice was high among sub-strains, the degree of the involvement of each gene related to calcification seems to differ among sub-strains of DBA/2 mice, in which DBA/2CrSlc sub-strain may develop calcification with a high incidence because of the unique profile of these genes.…”

Idiopathic calcinosis of the tongue

“…2 Idiopathic calcinosis of the tongue has been reported as well in a mature domestic cat 3 and in the tongues of DBA/ 2NCrj mice. 4 Simple surgical methods of removal are the treatment of choice in order to exclude malignancy.…”