2023
DOI: 10.46542/pe.2023.234.340343
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The activity of bioactive compounds from bidara upas (Merremia mammosa (Lour) Hall. f.) as an inhibitor of SARS-CoV2 entry stage: In silico study

Neny Purwitasari,
Mangestuti Agil,
Siswandono Siswodihardjo
et al.

Abstract: Background: Covid 19 is a global pandemic caused by SARS-CoV2, a novel coronavirus. This virus enters target organ epithelial cells by utilising two host proteins; Transmembrane Serine Protease 2 (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2). The inhibition of TMPRSS2 has shown to be a promising means to prevent viral infection. Molecular docking, and Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis will determine the activity of Merremia mammosa (Lour) Hall.f. secondary me… Show more

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