The Activity of Gamma Irradiated Poly (Thiourea–Formaldehyde) Resin against Aquatic Microbes and Cytotoxic Activity

al., Ahmed Awadallah-F et

doi:10.21608/ejabf.2022.273377

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The homogeneity of the continuous structure was more observed with higher From the overall characterization, the proposed chemical reaction mechanism of the gamma-ray effect on rosin was presented in Fig. 7, while similar reactions were reported by scientists before 47,48 . The suggested reaction mechanisms were showing the double bond rearrangement of abietic acid forming the isomer levopimaric acid and several dimers.…”

Section: Resultssupporting

confidence: 69%

Influence of gamma irradiation on rosin properties and its antimicrobial activity

Badr

Awadallah‐F

Azzam

et al. 2023

Sci Rep

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The main component of rosin natural gum is abietic acid, which has an interesting chemical structure to be studied with the influence of gamma-ray and the antimicrobial activity on the properties of a cheap abundant solid state natural material of rosin. Rosin is exposed to a wide scale of gamma-ray ranges from 0 to 100 kGy. The changes in the properties are tracked by various techniques of FTIR, XRD, TGA, GPC, and SEM. The molecular weight of rosin changes from 370 g/mol to higher and the morphological properties were investigated. The irradiated rosin acid (IRA) at different irradiation doses exploited antimicrobial effect versus Gram-positive and Gram-negative as well. The inhibition zone enhanced from 15 to 33, 14 to 28, 14 to 20, and 9 to 14 mm for Gram-positive and Gram-negative, respectively. Moreover, bioactive behavior for irradiated rosin of 40 kGy recorded the highest antibacterial activity against both types of bacteria. The outcome data of antimicrobial activity are good and confirm that there is a significant effect of irradiation dose on the biocidal activity of rosin.

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Section: Resultssupporting

confidence: 69%

Influence of gamma irradiation on rosin properties and its antimicrobial activity

Badr

Awadallah‐F

Azzam

et al. 2023

Sci Rep

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“…To establish control, a solution comprising isopropanol and hydrochloric acid was employed, and its measurement was deducted from the recorded values of the other samples. The Equation (1) was employed to calculate the percentage of cell viability ( 25 – 28 ):…”

Section: Methodsmentioning

confidence: 99%

Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway

Kodous,

Abdel-Maksoud,

El-Tayeb

et al. 2024

Front. Immunol.

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IntroductionSkin injuries represent a prevalent form of physical trauma, necessitating effective therapeutic strategies to expedite the wound healing process. Hesperidin, a bioflavonoid naturally occurring in citrus fruits, exhibits a range of pharmacological attributes, including antimicrobial, antioxidant, anti-inflammatory, anticoagulant, and analgesic properties. The main objective of the study was to formulate a hydrogel with the intention of addressing skin conditions, particularly wound healing.MethodsThis research introduces a methodology for the fabrication of a membrane composed of a Polyvinyl alcohol - Sodium Alginate (PVA/A) blend, along with the inclusion of an anti-inflammatory agent, Hesperidin (H), which exhibits promising wound healing capabilities. A uniform layer of a homogeneous solution comprising PVA/A was cast. The process of crosslinking and the enhancement of hydrogel characteristics were achieved through the application of gamma irradiation at a dosage of 30 kGy. The membrane was immersed in a Hesperidin (H) solution, facilitating the permeation and absorption of the drug. The resultant system is designed to deliver H in a controlled and sustained manner, which is crucial for promoting efficient wound healing. The obtained PVA/AH hydrogel was evaluated for cytotoxicity, antioxidant and free radical scavenging activities, anti-inflammatory and membrane stability effect. In addition, its action on oxidative stress, and inflammatory markers was evaluated on BJ-1 human normal skin cell line.Results and DiscussionWe determined the effect of radical scavenging activity PVA/A (49 %) and PVA/AH (87%), the inhibition of Human red blood cell membrane hemolysis by PVA/AH (81.97 and 84.34 %), hypotonicity (83.68 and 76.48 %) and protein denaturation (83.17 and 85.8 %) as compared to 250 μg/ml diclofenac (Dic.) and aspirin (Asp.), respectively. Furthermore, gene expression analysis revealed an increased expression of genes associated with anti-oxidant and anti-inflammatory properties and downregulated TNFα, NFκB, iNOS, and COX2 by 67, 52, 58 and 60%, respectively, by PVA/AH hydrogel compared to LPS-stimulated BJ-1 cells. The advantages associated with Hesperidin can be ascribed to its antioxidant and anti-inflammatory attributes. The incorporation of Hesperidin into hydrogels offers promise for the development of a novel, secure, and efficient strategy for wound healing. This innovative approach holds potential as a solution for wound healing, capitalizing on the collaborative qualities of PVA/AH and gamma irradiation, which can be combined to establish a drug delivery platform for Hesperidin.

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Gamma radiation assisted green synthesis of hesperidin-reduced graphene oxide nanocomposite targeted JNK/SMAD4/MMP2 signaling pathway

Kodous,

Taha,

El-Maghraby

et al. 2024

Sci Rep

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In this study, a novel method for the fabrication of hesperidin/reduced graphene oxide nanocomposite (RGOH) with the assistance of gamma rays is reported. The different RGOHs were obtained by varying hesperidin concentrations (25, 50, 100, and 200 wt.%) in graphene oxide (GO) solution. Hesperidin concentrations (25, 50, 100, and 200 wt.%) in graphene oxide (GO) were varied to produce the various RGOHs. Upon irradiation with 80 kGy from γ-Ray, the successful reduction of GO occurred in the presence of hesperidin. The reduction process was confirmed by different characterization techniques such as FTIR, XRD, HRTEM, and Raman Spectroscopy. A cytotoxicity study using the MTT method was performed to evaluate the cytotoxic-anticancer effects of arbitrary RGOH on Wi38, CaCo2, and HepG2 cell lines. The assessment of RGOH’s anti-inflammatory activity, including the monitoring of IL-1B and IL-6 activities as well as NF-kB gene expression was done. In addition, the anti-invasive and antimetastatic properties of RGOH, ICAM, and VCAM were assessed. Additionally, the expression of the MMP2-9 gene was quantified. The assessment of apoptotic activity was conducted by the detection of gene expressions related to BCl2 and P53. The documentation of the JNK/SMAD4/MMP2 signaling pathway was ultimately accomplished. The findings of our study indicate that RGOH therapy has significant inhibitory effects on the JNK/SMAD4/MMP2 pathway. This suggests that it could be a potential therapeutic option for cancer.

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The Activity of Gamma Irradiated Poly (Thiourea–Formaldehyde) Resin against Aquatic Microbes and Cytotoxic Activity

Cited by 3 publications

References 10 publications

Influence of gamma irradiation on rosin properties and its antimicrobial activity

Influence of gamma irradiation on rosin properties and its antimicrobial activity

Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway

Gamma radiation assisted green synthesis of hesperidin-reduced graphene oxide nanocomposite targeted JNK/SMAD4/MMP2 signaling pathway

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