The activity of interferon on ultraviolet light-induced squamous cell carcinomas in mice

Brysk, Miriam M.; Tschen, Eduardo; Hudson, Robert D.; Smith, Edgar B.; Fleischmann, W. Robert; Black, Homer S.

doi:10.1016/s0190-9622(81)70078-1

Cited by 19 publications

(4 citation statements)

References 9 publications

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“…Potentiation of natural killing activity by combinations of IFN. Since immune and virus-type IFN have synergistic antiviral (6), antitumor (3,7), and anticellular activities (5), we next determined whether combinations of different IFN types would be additive or possibly synergistic in the enhancement of natural killing of mouse L a Lymphocytes were cultured with the various IFNs for 18 h at 37°C. After washing out the IFN, the cells were cultured with L cells for 16 h at a ratio of 10 lymphocytes to 1 target cell, and the percent specific 5"Cr release was determined.…”

Section: Resultsmentioning

confidence: 99%

Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon

Weigent¹,

Langford²,

Fleischmann³

et al. 1983

Infect Immun

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Section: Resultsmentioning

confidence: 99%

Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon

Weigent¹,

Langford²,

Fleischmann³

et al. 1983

Infect Immun

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“…Lambert and co‐workers 13 have shown that leukocytes in patients with multiple actinic keratoses have a DNA repair capacity 30% below that of age‐ and sex‐matched controls. Also, the aggressive biological behavior of this SCC raises questions as to the effectiveness of the patient's immune system since the degree of lymphocytic infiltrate and interferon production has previously been correlated with the growth of SCC 14–17 . However, this patient's primary tumor contained a lymphocyte‐rich infiltrate and the patient had no known immunosuppression.…”

Section: Discussionmentioning

confidence: 97%

Fatal Cutaneous Squamous Cell Carcinoma in a Forty‐Three‐Year‐Old Male

Mohle

Nickoloff

1986

The Journal of Dermatologic Surgery and Oncology

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A 43‐year‐old patient with a history of squamous cell carcinoma (SCC) of the lip, multiple actinic keratoses, and multiple sequential SCC on sun‐exposed areas of his skin developed a subcutaneous nodule of SCC in an area where a cutaneous SCC had been excised 1 year previously. At the time of the subcutaneous nodule there was no evidence of metastases; 5 months later he had metastatic bone disease as well as apparent metastases to myocardium, pericardium, and pleura. The patient is notable for the young age at primary diagnosis of SCC, the fulminant lethal course of a tumor which is generally considered curable, and a family history to which SCC occurred over three generations.

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“…These findings suggest that IFN may need to be combined with other antitumor agents, including [2,3,6]. Furthermore, the combination of type I and type II exhibited inhibition of tumor growth synergistically in vitro [6,9,19,28] and in vivo [4,10,25]. We have also demonstrated that the combination of murine recombinant IFN[3 (MurIFN[3) and Mu-rIFNy as biological response modifiers has a synergistic antitumor activity for mice bearing MethA and methylcholanthrene-induced fibrosarcoma (unpublished results).…”

mentioning

confidence: 99%

Antitumor effect of combination of murine recombinant interferon β, murine recombinant interferon γ and human recombinant interleukin-2 in MethA-bearing mice

Itoh

Sakata

Yoshida

et al. 1990

Cancer Immunol Immunother

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We have previously reported that the combination of murine recombinant interferon beta (Mu-rIFN beta) with murine recombinant interferon gamma (Mu-rIFN gamma) provided greater inhibition of tumor growth than did each one alone in MethA-bearing mice. In the present study the effect of addition of human recombinant interleukin-2 (Hu-rIL-2) to the combination of Mu-rIFN beta with Mu-rIFN gamma on tumor growth in BALB/c mice bearing syngeneic MethA fibrosarcoma was examined. Low doses of Hu-rIL-2 (5 x 10(3) U or 5 x 10(4) U at 3-day intervals) showed no antitumor activity, while a high dose of Hu-rIL-2 (5 x 10(5) U) showed profound growth inhibition. The administration of IL-2 (ranging between 5 x 10(3) U and 5 x 10(5) U) in addition to the combination of IFN beta and IFN gamma showed more augmented antitumor effects in a dose-dependent manner. Furthermore, the simultaneous administration of IL-2, IFN beta and IFN gamma had more effective therapeutic activity, compared with the sequential administration of interferons and IL-2. These findings indicated that IL-2 in combination with IFN beta and gamma was effective for cancer treatment.

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The activity of interferon on ultraviolet light-induced squamous cell carcinomas in mice

Cited by 19 publications

References 9 publications

Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon

Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon

Fatal Cutaneous Squamous Cell Carcinoma in a Forty‐Three‐Year‐Old Male

Antitumor effect of combination of murine recombinant interferon β, murine recombinant interferon γ and human recombinant interleukin-2 in MethA-bearing mice

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