The activity of N-acetyl-beta-d-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children

Myśliwiec, Małgorzata; Zorena, Katarzyna; Balcerska, Anna; Myśliwska, Jolanta; Lipowski, Paweł; Raczyńska, Krystyna

doi:10.1016/j.clinbiochem.2006.03.013

Cited by 30 publications

(18 citation statements)

References 40 publications

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“…Our results have confirmed increased activity of TNF-␣ and IL-6 and decreased activity of IL-10 in DM1 patients, especially among children who had the course of disease complicated by occurrence of pathologic events in the kidneys and eye apparatus (7).…”

Section: Discussionsupporting

confidence: 73%

“…Authors of a few published studies suggest that immunologic processes responsible for destruction of pancreatic ␤ cells at an early stage of DM1 development persist during the chronic stage of the disease and might influence the development of late complications, including diabetic nephropathy and retinopathy (17)(18)(19). Our results have confirmed increased activity of TNF-␣ and IL-6 and decreased activity of IL-10 in DM1 patients, especially among children who had the course of disease complicated by occurrence of pathologic events in the kidneys and eye apparatus (7).…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies have shown that TNF-␣ and IL-6 play crucial role in the mechanisms of damage to the eye apparatus and kidneys of the diabetic patients (7)(8)(9)(10). It remains unresolved to what extent changes in the levels of pro-and antiinflammatory cytokines that occur in the course of DM1 might affect occurrence of celiac disease in such patients.…”

mentioning

confidence: 99%

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Immunologic and Biochemical Factors of Coincident Celiac Disease and Type 1 Diabetes Mellitus in Children

et al. 2008

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Immunologic and Biochemical Factors of Coincident Celiac Disease and Type 1 Diabetes Mellitus in Children

et al. 2008

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“…It has been shown to inhibit neovascularization resulting from hypoxia in animals [40], but the relationship between IL-10 and diabetic retinopathy is not clear [39]. Another study was shown that IL-10 levels are higher in eyes without diabetic retinopathy than in eyes with diabetic retinopathy [41], and another authors showed that vitreous IL-10 levels were increased in eyes with proliferative diabetic retinopathy [42].…”

Section: Inflammatory and Anti-inflammatory Cytokinesmentioning

confidence: 99%

“…It is known that IL-10 is an anti-inflammatory cytokine that is produced by activated monocyte, macrophage, T lymphocyte, and B lymphocytes [39]. It has been shown to inhibit neovascularization resulting from hypoxia in animals [40], but the relationship between IL-10 and diabetic retinopathy is not clear [39].…”

Section: Inflammatory and Anti-inflammatory Cytokinesmentioning

confidence: 99%

Different Concentrations of Aqueous Cytokines According to Diabetic Macular Edema Patterns as Determined Optical Coherence Tomography

Jeong¹

2014

J Clin Exp Ophthalmol

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Objective: To evaluate the relationship between various cytokine levels in aqueous humor and diabetic macular edema (DME) types as determined by optical coherence tomographic (OCT) patterns. Methods:The study examined 76 patients with DME at early phase. Ten patients who underwent cataract surgery served as controls. Eyes with DME were divided into four groups, based on OCT patterns of DME, prior to intravitreal bevacizumab injection (IVB). Patterns included sponge-like diffuse retinal thickening (SDRT) (n=27), cystoid macular edema (CME) (n=18), serous retinal detachment (SRD) (n=15), and combined CME and SRD (n=16). Visual acuity, central macular thickness (CMT) through OCT, and aqueous cytokine concentrations of interleukin (IL)-6, IL-8, IL-10, IL-13, monocyte chemo attractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF) were measured in all subjects. The odds ratio (OR) between aqueous cytokines and each DME pattern were calculated using multivariate regression analysis.Results: After IVB, CMT was reduced in all groups, but the highest reduction ratio occurred in eyes with SDRT and CME. Aqueous analyses showed that VEGF was associated with development of SDRT (P=0.003, OR=1.043, 95% CI=1.015-1.072). IL-6, MCP-1 were related with CME (P<0.001, OR=1.025, 95% CI=1.011-1.039; P<0.001, OR=1.003, 95% CI=1.001-1.004, respectively). IL-6 was also associated with SRD (P=0.045, OR=1.018, 95% CI=1.006-1.030). Furthermore, IL-6, VEGF were related with Combined pattern (P=0.031, OR=1.013, 95% CI=1.002-1.024; P=0.038, OR=1.014, 95% CI=1.014-1.043, respectively).Conclusion: Specific aqueous cytokines may play an important role in developing each DME pattern based on OCT.

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Urinary biomarkers involved in type 2 diabetes: a review

Matheson¹,

Willcox

Flanagan

et al. 2010

Diabetes Metabolism Res

131

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Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is of critical concern. Development of a diagnostic test, more convenient and reliable than those currently used, would therefore be highly beneficial. Urine as a diagnostic medium allows for non-invasive detection of biomarkers, including some associated with type 2 diabetes and its complications. This review provides a synopsis of those urinary biomarkers that potentially may provide a basis for the development of improved diagnostic tests. Three main pathways for the sourcing of potential makers are identified: kidney damage, oxidative stress and low-grade inflammation including atherosclerosis/vascular damage. This review briefly presents each pathway and some of the most relevant urinary biomarkers that may be used to monitor the development or progression of diabetes and its complications. In particular, biomarkers of renal dysfunction such as transferrin, type IV collagen and N-acetyl-beta-D-glucosaminidase might prove to be more sensitive than urinary albumin, the current gold standard, in the detection of incipient nephropathy and risk assessment of cardiovascular disease. Inflammatory markers including orosomucoid, tumour necrosis factor-alpha, transforming growth factor-beta, vascular endothelial growth factor and monocyte chemoattractant protein-1, as well as oxidative stress markers such as 8-hydroxy-2'deoxyguanosine may also be useful biomarkers for diagnosis or monitoring of diabetic complications, particularly kidney disease. However, the sensitivity of these markers compared with albumin requires further investigation.

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The activity of N-acetyl-beta-d-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children

Cited by 30 publications

References 40 publications

Immunologic and Biochemical Factors of Coincident Celiac Disease and Type 1 Diabetes Mellitus in Children

Immunologic and Biochemical Factors of Coincident Celiac Disease and Type 1 Diabetes Mellitus in Children

Different Concentrations of Aqueous Cytokines According to Diabetic Macular Edema Patterns as Determined Optical Coherence Tomography

Urinary biomarkers involved in type 2 diabetes: a review

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