The activity of pramipexole in the mouse forced swim test is mediated by D2 rather than D3 receptors

Abstract

Taken together, these studies suggest that the D2 receptor rather than the D3 receptor is important for the antidepressant-like activity observed for pramipexole in the mouse forced swim test.

Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

“…Locomotor activity Locomotor activity was performed as previously described (Siuciak and Fujiwara 2004). Separate groups of mice were used for all locomotor studies.…”

Long-term treatment with l-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease

“…This (Favier et al, 2014;Schulte-Herbruggen et al, 2012;Siuciak and Fujiwara, 2004) and in clinical trials alone (Barone et al, 2010) or in combination with L-DOPA (Rektorova et al, 2005). In autoradiography studies PPX binding was shown to be high also in mesolimbic areas like the nucleus accumbens, olfactory tubercle and amygdala.…”

“…Besides its effect on PD motor symptoms (Ferger et al, 2010;Lagos et al, 1998), PPX has also been shown to have antidepressant effects in animal models of PD (Schulte-Herbruggen et al, 2012;Siuciak and Fujiwara, 2004) and in clinical trials, alone (Barone et al, 2010) or combined with L-DOPA (Rektorova et al, 2005). L-DOPA alone did not show any anti-depressive or anxiolytic effects (Eskow Jaunarajs et al, 2012).…”

Behavioral Actions of Intranasal Application of Dopamine: Effects on Forced Swimming, Elevated Plus-Maze and Open Field Parameters

“…The results on behavior in the novel and familiar environments in the present study resemble those found for other dopamine D 2 -receptor agonists. Thus, it was found that pramipexole decreases locomotor behavior in rats and mice in a novel environment in low doses, but increases motor activity in a familiar environment in higher doses (3.2 mg/kg) [79,80] . These lines of evidence support the view, that exogenous DA, applied via the nasal route, exerted its behavioral effects by actions on D 2 -receptors, although participation of D 1 -or D 3 -receptors cannot be excluded.…”