The Activity of Purple Sweet Potato Extract on Antituberculosis-Induced Liver Toxicity

Artini, I Gusti Ayu; Indrayani, Agung Wiwiek; Artana, Gusti Ngurah Bagus; Aman, Gusti Made; Dewi, Ni Wayan Sucindra

doi:10.3889/oamjms.2022.8753

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…According to a previous study reported by Soedarsono et al [35], rifampicin activates isoniazid hydrolase when used together, which increases the production of hydrazine and may account for their greater toxicity. Moreover, Artini et al [36] demonstrated that INH-induced oxidative stress can promote apoptotic conditions in cells, as indicated by the overexpression of the hepatic caspase-3 levels.…”

Section: Well-dispersible Nanoparticles (Sps-senps) [6 and 22]mentioning

confidence: 99%

Hepatoprotective effect of selenium nanoparticles coated with Spirulina polysaccharides against anti-tuberculosis drugs induced apoptosis

Afifi,

Hamza,

Boraei

et al. 2023

Preprint

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This study aims to evaluate the ameliorating effect of selenium nanoparticles (SeNPs) coated with Spirulina polysaccharides (SPs-SeNPs) against anti-tuberculosis drugs (ATDs) induced hepatotoxicity and apoptosis in a trial to enhance the drug efficacy and tolerance, as well as to improve the chance of recovery of tuberculosis patients. The results revealed that utilizing SPs as a capping agent resulted in size-controlled, highly stable, and monodispersed spherical SeNPs with an average diameter < 50 nm. When compared to ATDs-treated animals, co-administration of either SPs (0.5mg /kg bw/day/8 weeks), SeNPs (0.5mg /kg bw/day/8 weeks) or SPs-SeNPs (0.5mg /kg bw/day/8 weeks) together with the ATDs[ ((Isoniazid (INH; 50 mg/kg) + Rifampicin (RIF;100 mg/kg) + Pyrazinamide (PZA;350 mg/kg)) /day/8 weeks ] for to rats modulated ATDs-induced side effects as evidenced by reductions in CYP2E1, CASPASE-3, malondialdehyde (MDA) concentration, liver function enzymes, levels of total bilirubin with elevation in total antioxidant capacity (TAC) and glutathione content (GSH) levels. These findings also demonstrated that treatment with SPs-SeNPs had a greater significant effect on ATDs-induced damage than treating with SPs or SeNPs alone. The results suggested that SPs–SeNPs could be a promising anti-toxic and antioxidant agent, and the strategy of using SPs as a surface decorator could be a very effective way to enhance the efficacy of nanomaterials.

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Section: Well-dispersible Nanoparticles (Sps-senps) [6 and 22]mentioning

confidence: 99%

Hepatoprotective effect of selenium nanoparticles coated with Spirulina polysaccharides against anti-tuberculosis drugs induced apoptosis

Afifi,

Hamza,

Boraei

et al. 2023

Preprint

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“…The two pathways -intrinsic and extrinsic-are involve in RGC apoptosis. These routes connect to Caspase-3, a cysteine protease, and Bax, a Bcl-2 family [6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Intravitreal Resveratrol as Anti Apoptotic Agent Against Retinal Ganglion Cell Loss in Ischemic Reperfusion Injury

Prasetya,

Komaratih,

Sasono

et al. 2024

Pharmacogn J.

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The in vivo experimental with post-test-only study was conducted in Universitas Airlangga from July 2022-January 2023. Mice models were used as the research subject, which were then divided into 4 groups through simple random sampling. The total research subjects were 20 eyeballs of Rattus Norvegicus. The groups were coded group G0, G1, G2, and G3. G0 was a control group with no treatment and enucleated at day 0. G1 was given I-R injury and enucleated at day 0 (IR0). G2 was given I-R injury, injected with intravitreal phosphate-ABSTRACT Background: Glaucoma is an optic neuropathy caused by the apoptosis of retinal ganglion cells and results in progressive retinal ganglion cell injury. A decrease in intraocular pressure (IOP) is a modifiable risk factor for slowing the progression of the disease, and can be accomplished through medication, laser therapy, or surgery. Even though the intraocular pressure has decreased and attained normal levels, the injury to the retinal ganglion cells continues in some cases. It is believed that neuroprotective administration has a positive effect on preventing the loss of retinal ganglion cells. Methods: Bax and Caspase-3 expression were measured involving 20 eyeballs of Rattus Norvegicus by immunohistochemistry examination. I-R injury was developed by increasing intraocular pressure (IOP) through the intracameral balanced salt solution (BSS) injection, then lowered after 60 minutes. Samples were divided into 4 groups: control, no further injection group, phosphate-buffered saline (PBS)-injected group and resveratrol-injected group. Each group was enucleated at days 7, 0, 7, and 7, respectively. Data with a non-normal distribution were examined using the Kruskal-Wallis test, and if the outcome was significant, the Mann-Whitney test. Results:The highest mean Bax and Caspase-3 expression was found in PBS injected and enucleated at day 7 group (G2), 0.96±0.40 and 0.72 ± 0.30, respectively. When compared to PBS injection, the expression of Bax and Caspase-3 was lower in the resveratrol-injected group. Conclusion: Bax and Caspase-3 expressions were lower in the intravitreal injection of Resveratrol in the dose of 100 µM following the I-R injury group compared to the group without intravitreal Resveratrol injection.

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Phytochemical compounds and pharmacological activities of Ipomoea batatas L.: An updated review

Suhendy,

Fidrianny,

Insanu

2023

PHAR

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This article provides an overview of Ipomoea batatas L., the Ipomoea genus. The review covers traditional uses, nutritional value, phytochemical compounds, pharmacological activities, and toxicity studies. Data were collected from scientific databases and search engines. Sweet potatoes are used in various countries for traditional uses such as dietary fiber sources, treating allergies, and providing energy in diabetes mellitus treatment. The primary phytochemical compounds in Ipomoea batatas are phenolic compounds, flavonoids, anthocyanins, and carotenoids. Sweet potato contains several nutritional constituents: vitamin C, protein, fiber, carbohydrates, β-carotene, and minerals. Sweet potato exhibits various pharmacological activities, such as antioxidant, aphrodisiac, anticancer, and anti-inflammatory. The types of phytochemical compounds in each part of the plant are different. Each pharmacological activity and mechanism of action depends on the phytochemical compounds, part and variety of the plant, and extraction solvent. However, further study is required to investigate the chronic toxicity of Ipomoea batatas.

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The Activity of Purple Sweet Potato Extract on Antituberculosis-Induced Liver Toxicity

Cited by 3 publications

References 21 publications

Hepatoprotective effect of selenium nanoparticles coated with Spirulina polysaccharides against anti-tuberculosis drugs induced apoptosis

Hepatoprotective effect of selenium nanoparticles coated with Spirulina polysaccharides against anti-tuberculosis drugs induced apoptosis

Intravitreal Resveratrol as Anti Apoptotic Agent Against Retinal Ganglion Cell Loss in Ischemic Reperfusion Injury

Phytochemical compounds and pharmacological activities of Ipomoea batatas L.: An updated review

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