The impact of the emissions from a municipal Waste-to-Energy (WtE) plant in Northern Italy on local air quality was assessed using the CALMET-CALPUFF atmospheric dispersion modelling system. Model simulations were based on hourly emission rates measured by continuous stack monitoring systems and considered both air quality-regulated pollutants (nitrogen oxides, particulate matter, toxic elements, benzo(a)pyrene), and other trace pollutants typical of WtE plants (dioxins, furans, and mercury). The model results were compared to both long-term observations from the air quality monitoring network and with short-term measurements from dedicated monitoring campaigns in the vicinity of the WtE plant, in both warm and cold season conditions. Modelling and observational results showed that the estimated plant contributions are very limited. This suggests that the observed concentration levels were the result of the contribution of all the sources distributed over the area and that they were not solely driven by the activity of the plant. Estimated contributions from the plant’s emissions were usually at least two orders of magnitudes lower than the ambient levels at the nearest monitoring site and even lower at the farthest sites.