The acute effect of hydrocortisone, deoxycorticosterone and aldosterone upon the excretion of sodium, potassium and acid by the human kidney

Mills, J. N.; Thomas, Sophie; Williamson, Kelly S.

doi:10.1113/jphysiol.1960.sp006440

Cited by 46 publications

(13 citation statements)

References 25 publications

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“…The rise in potassium excretion produced by hydrocortisone confirms the conclusion that this agent increases the sodium/potassium exchange process (2,3,16,30) located in the late distal tubule and collecting duct (31,32). Since the increment in potassium excretion was associated with a fall in sodium excretion, this alteration in potassium excretion apparently was due primarily to a direct hormonal effect.…”

Section: Resultssupporting

confidence: 64%

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Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Yunis¹,

Bercovitch²,

Stein³

et al. 1964

J. Clin. Invest.

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Section: Resultssupporting

confidence: 64%

“…Aldosterone has been reported to decrease sodium and chloride and to increase potassium and hydrogen ion excretion (1)(2)(3). With the stop-flow technique, this increment in sodium and chloride reabsorption was localized to the distal tubule (4.…”

mentioning

confidence: 99%

Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Yunis¹,

Bercovitch²,

Stein³

et al. 1964

J. Clin. Invest.

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“…The most interesting observations here are those during the last 3 days on subject D.L., when both plasma steroids and urinarypotassium followed a rhythm with a period around 16 h. Little evidence is available on whether the phase delay of 5 h is plausible, if periodic steroid production were the cause of the rhythm in urinary potassium. Prolonged renal effects have been observed after single injections of cortisol (Mills & Thomas, 1958;Mills et al 1960;Mills, Thomas & Williamson, 1961), but the doses used were larger than any likely to be secreted by the adrenals in a short period.…”

Section: Free-running Circadian Rhythms In Man 581mentioning

confidence: 99%

The circadian rhythms of human subjects without timepieces or indication of the alternation of day and night

Mills¹,

Minors²,

Waterhouse³

1974

The Journal of Physiology

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1. Seven solitary subjects, and two groups of four, spent from 5 to 13 days in an isolation unit without knowledge of time. Three solitary subjects and one group of four adopted fairly regular activity habits with a period of 25–27 h; one subject adopted a period of 30 h, and one of 27 h initially, decreasing to 24–25 h after a few days. One group of four awoke roughly every 24 h, after a sleep which was alternately about 8 h, or about 4 h and believed by the subjects to be an afternoon siesta. Two solitary subjects alternated sleeps of about 8 or 16 h, separated by 24 h of activity. 2. Deep temperature in all subjects oscillated with a period of 24–26 h, which was thus commonly distinct from their activity habits. 3. Urinary potassium followed a rhythm whose period, though usually close to, was sometimes distinct from, that of temperature. A secondary period corresponding to that of activity was also sometimes present. 4. Urinary sodium and chloride usually gave evidence of two periodic components, one corresponding to activity and the other to the rhythm of either temperature or of urinary potassium. 5. Urinary creatinine and phosphate usually followed the subject's routine of activity. 6. Plasma samples were collected on a few occasions and analysed for phosphate and 11–hydroxycorticosteroids. Changes in plasma phosphate were usually, but not always, associated with similar changes in urinary phosphate, and changes in plasma corticosteroids were often, but not always, associated with similar changes in urinary potassium shortly afterwards. 7. Observations are recorded on a subject alone in a cave for 127 days. His activity habits, though wildly variable, gave evidence of a period of 25·1 h and his urinary electrolyte excretion indicated a shorter period, of 24·6 h. During the following 3 days, when he remained in the cave but was visited frequently, his plasma corticosteroids and urinary potassium oscillated with a period of 16 h. 8. The possible mechanisms controlling these rhythms are discussed.

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“…A role for the adrenal cortex in the regulation of acidbase homeostasis has been apparent from both clinical and experimental observations (1)(2)(3)(4)(5)(6)(7)(8)(9). Several extrarenal factors, such as changes in volume status, alteration of potassium balance, and changes in filtered nonbicarbonate buffer have been shown to affect the renal response to alterations in plasma levels of adrenal steroids.…”

Section: Introductionmentioning

confidence: 99%

Mineralocorticoid modulation of rabbit medullary collecting duct acidification. A sodium-independent effect.

Seldin²,

et al. 1983

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A B S T R A C T Rabbit medullary collecting duct (MCD) from inner stripe of outer medulla has been identified as a major distal nephron acidification site. The isolated, perfused tubule technique was used to examine the roles of mineralocorticoid and glucocorticoid in regulation of MCD acidification. Surgical adrenalectomy reduced bicarbonate reabsorptive rate (JHCO3, pmol * mm-'l min-') from the normal of 9.79±1.21 to 0.67±1.1. Chronic administration of deoxycorticosterone acetate (DOCA) increased JHCO3 of MCD significantly to 18.02±1.62 whereas chronic dexamethasone administration did not affect JHCO3. The direct effects of aldosterone and dexamethasone upon MCD acidification were examined by perfusing tubules harvested from adrenalectomized rabbits in the presence of aldosterone or dexamethasone. Aldosterone, at 5 X 10-8 M, increased JHCO3 significantly from 1.27±0.28 to 3.09±0.34. At 10-6 M, aldosterone produced a greater increase in JHCO3 from 0.67±1.1 to 9.39±1.59. In vitro dexamethasone treatment had no effect on JHCO3. Studies examining the sodium dependence of aldosterone-stimulated acidification demonstrated that JHCO3 in tubules harvested from normal and deoxycorticosterone acetate-treated animals was unaffected by total replacement of sodium with tetramethylammonium. Likewise, luminal amiloride (5 X 10-5 M) had no effect on JHCO3 in tubules har-

show abstract

The acute effect of hydrocortisone, deoxycorticosterone and aldosterone upon the excretion of sodium, potassium and acid by the human kidney

Cited by 46 publications

References 25 publications

Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

The circadian rhythms of human subjects without timepieces or indication of the alternation of day and night

Mineralocorticoid modulation of rabbit medullary collecting duct acidification. A sodium-independent effect.

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