The acute effect of pilocarpine on pulsatile ocular blood flow in ocular hypertension

Shaikh, M H; Mars, J S

doi:10.1038/eye.2001.15

Cited by 13 publications

(7 citation statements)

References 14 publications

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“…78 Pilocarpine significantly increased pulsatile ocular blood flow in patients with untreated OHT in one study. 79 In contrast, studies conducted in patients with glaucoma as well as in healthy volunteers found no effect of pilocarpine on the pulsatile component of ocular blood flow. 80,81 There is no study supporting that parasympathomimetics exert any non-IOPrelated neuroprotective effects in glaucoma patients.…”

Section: Topical Therapiesmentioning

confidence: 96%

Pharmacotherapy of Glaucoma

Schmidl

Schmetterer²,

Garhöfer³

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

136

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Glaucoma is a group of diseases involving the optic nerve and associated structures, which is characterized by progressive visual field loss and typical changes of the optic nerve head (ONH). The only known treatment of the disease is reduction of intraocular pressure (IOP), which has been shown to reduce glaucoma progression in a variety of large-scale clinical trials. Nowadays, a relatively wide array of topical antiglaucoma drugs is available, including prostaglandin analogues, carbonic anhydrase inhibitors, beta-receptor antagonists, adrenergic agonists, and parasympathomimetics. In clinical routine, this allows for individualized treatment taking risk factors, efficacy, and safety into account. A major challenge is related to adherence to therapy. Sustained release devices may help minimize this problem but are not yet available for clinical routine use. Another hope arises from non-IOP-related treatment concepts. In recent years, much knowledge has been gained regarding the molecular mechanisms that underlie the disease process in glaucoma. This also strengthens the hope that glaucoma therapy beyond IOP lowering will become available. Implementing this concept with clinical trials remains, however, a challenge.

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Section: Topical Therapiesmentioning

confidence: 96%

Pharmacotherapy of Glaucoma

Schmidl

Schmetterer²,

Garhöfer³

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

136

View full text Add to dashboard Cite

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“…The pulsatile component of ocular blood flow is primarily choroidal. 5 It has been clinically applied to investigate in various ocular diseases including glaucoma, 6,7 age-related macular degeneration, 8,9 diabetic retinopathy, 10,11 choroidal melanoma, 12 and retinal pigmentosa. 13 Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, diffuse goitre, ophthalmopathy, and rarely, dermopathy.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Tsai

Kau

Kao

et al. 2004

Eye

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Purpose Graves' ophthalmopathy (GO) is a cosmetically disfiguring and visionthreatening complication of Graves' disease (GD). We investigated the clinical application of pulsatile ocular blood flow (POBF) measurement for detection of clinically active GO. Methods In this prospective study, the OBF tonometer (OBF Labs, Wiltshire, UK) was used to measure POBF in 83 eyes of 83 patients with GD in two groups and 42 normal control subjects. Group A comprised 35 GD patients without ophthalmopathy, and group B composed 48 GD patients with ophthalmopathy. Results were compared with controls. Results Pulse amplitude, pulse volume, and POBF were significantly lower in group B than that in group A and controls (Po0.001). After adjusting for age, sex, systolic blood pressure, diastolic blood pressure, heart rate, intraocular pressure, and axial length, multivariate linear regression analysis showed that POBF was still significantly lower in eyes with GO (772.4 (SD 279.3) ll/min) than group A (1177.3 (SD 326.3) ll/min) and controls (1255.4 (SD 295.1) ll/min) (Po0.001). Conclusions These data show that the pulsatile ocular blood flow differences between the groups are relevant to the presence of GO. POBF measurement is a clinically useful adjunct for assessing the haemodynamic change in GO patients.

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“…A study on human subjects undergoing cardiac catheterization reported that acetylcholine induced vasodilation in normal epicardial coronary arteries, but vasoconstriction in arteries with angiographically evident artherosclerosis. 17 Systemically and topically applied cholinergic agents were reported to increase ocular blood flow in experimental animals 40,41 and humans, 42 suggesting that acetylcholine may be involved in regulation of ocular perfusion by inducing vasodilation via activation of muscarinic receptors. However, as yet, no evidence for abnormal vasoconstriction to acetylcholine has been provided for the ocular circulation in a model of endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Role of the M₃Muscarinic Acetylcholine Receptor Subtype in Murine Ophthalmic Arteries After Endothelial Removal

Gericke

Steege

Manicam

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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The acute effect of pilocarpine on pulsatile ocular blood flow in ocular hypertension

Abstract: The acute effect of Conclusion Acute application of pilocarpine 2% drops increased POBF to a significant extent in untreated ocular hypertension.

Cited by 13 publications

References 14 publications

Pharmacotherapy of Glaucoma

Pharmacotherapy of Glaucoma

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Role of the M₃Muscarinic Acetylcholine Receptor Subtype in Murine Ophthalmic Arteries After Endothelial Removal

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The acute effect of pilocarpine on pulsatile ocular blood flow in ocular hypertension

Abstract: The acute effect of Conclusion Acute application of pilocarpine 2% drops increased POBF to a significant extent in untreated ocular hypertension.

Cited by 13 publications

References 14 publications

Pharmacotherapy of Glaucoma

Pharmacotherapy of Glaucoma

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Role of the M3Muscarinic Acetylcholine Receptor Subtype in Murine Ophthalmic Arteries After Endothelial Removal

Contact Info

Product

Resources

About

Role of the M₃Muscarinic Acetylcholine Receptor Subtype in Murine Ophthalmic Arteries After Endothelial Removal