The acute effect of psychosocial stress on the level of oxidative stress in children

Janšáková, Katarína; Belica, Ivan; Rajčániová, Eva; Rajčáni, Jakub; Kyselicová, Klaudia; Celušáková, Hana; Laznibatová, Jolana; Ostatníková, Daniela

doi:10.1016/j.ijpsycho.2021.01.007

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…In an experimental condition of acute psychological stress, such as the "Trier Social Stress Test" (TSST), Wiegand et al found that, among stress-associated changes, the expression of salivary microRNA (miRNA) involved in the cellular response managing oxidative stress was higher [37]. Moreover, healthy children, after a stress situation induced by the TSST, showed increased biomarkers of lipid peroxidation compared with a control day and increased markers of antioxidant status during the stress day [38]. Consistent with these findings, we observed that sNOX2-dp, a circulating biomarker of NOX2 activation, and H 2 O 2 levels increased on the day of the exam, with higher levels of both biomarkers significantly increased in participants that obtained results ≤ 24 when compared with those who obtained results > 24.…”

Section: Discussionmentioning

confidence: 99%

NOX2 as a Biomarker of Academic Performance: Evidence from University Students during Examination

Nocella,

D’Amico,

Cangemi

et al. 2024

Antioxidants

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Background: Cortisol levels, oxidative stress, and lower cerebral performance seem to be closely related. This study aimed to evaluate the question of whether exam stress affected oxidative stress and endothelial function parameters in the salivary samples of students. Methods: A total of 114 healthy students were recruited. All students were subjected to a 21-item DASS questionnaire to assess perceived stress. Cortisol levels, biomarkers of oxidative stress, and endothelial function were evaluated at T0, during the semester, and T1, in the morning before the exam, in saliva samples. In vitro, HUVECs were stimulated with cortisol, and oxidative stress and endothelial function parameters were evaluated. Results: At T1, cortisol levels were significantly increased compared with the levels during the semester. Moreover, exam results correlated inversely with the DASS score at T1. In addition, NOX2, H2O2 and endothelin-1 significantly increased, while NO bioavailability decreased. In vitro, HUVECs treatment with human cortisol determined the increase of oxidative stress and the decrease of endothelial function, in association with impaired eNOS phosphorylation. Conclusion: NOX2-mediated oxidative stress is a mechanism that could mediate cortisol-induced transient endothelial dysfunction during academic examination. Therefore, strategies to monitor or modulate oxidative stress could help students to reduce the impact of examination-related stress.

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Section: Discussionmentioning

confidence: 99%

NOX2 as a Biomarker of Academic Performance: Evidence from University Students during Examination

Nocella,

D’Amico,

Cangemi

et al. 2024

Antioxidants

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show abstract

Section: Discussionmentioning

confidence: 99%

“…Although many studies suggest that the chronic psychosocial stress is linked to OxSt and the pathologies of diverse diseases [ [6] , [7] , [8] , 45 , 46 , 124 , 125 ], few studies focus on the association between acute psychosocial stress and OxSt [ [126] , [127] , [128] ]. Jansakova et al [ 127 ] examined the acute effect of psychosocial stress on OxSt using saliva samples from children. They found increases in the total antioxidant capacity (as measured by ferric ion reducing antioxidant power) after exposure to acute psychosocial stress (e.g., TSST) during the stress day, and higher lipid peroxidation on stress day than control day but no significant difference prior to and post TSST.…”

Section: Discussionmentioning

confidence: 99%

Association of acute psychosocial stress with oxidative stress: Evidence from serum analysis

et al. 2021

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Growing evidence implicates an association between psychosocial stress and oxidative stress (OxSt) although there are not yet reliable biomarkers to study this association. We used a Trier Social Stress Test (TSST) and compared the response of a healthy control group (HC; N=10) against the response of a schizophrenia group (SCZ; N=10) that is expected to have higher levels of OxSt. Because our previous study showed inconsistent changes in conventional molecular markers for stress responses in the neuroendocrine and immune systems, we analyzed the same serum samples using a separate reducing capacity assay that provides a more global measurement of OxSt. This assay uses the moderately strong oxidizing agent iridium (Ir) to probe a sample's reducing capacity. Specifically, we characterized OxSt by this Ir-reducing capacity assay (Ir-RCA) using two measurement modalities (optical and electrochemical) and we tuned this assay by imposing an input voltage sequence that generates multiple output metrics for data-driven analysis. We defined five OxSt metrics (one optical and four electrochemical metrics) and showed: (i) internal consistency among each metric in the measurements of all 40 samples (baseline and post TSST for N=20); (ii) all five metrics were consistent with expectations of higher levels of OxSt for the SCZ group (three individual metrics showed statistically significant differences); and (iii) all five metrics showed higher levels of OxSt Post-TSST (one metric showed statistically significant difference). Using multivariant analysis, we showed that combinations of OxSt metrics could discern statistically significant increases in OxSt for both the SCZ and HC groups 90 min after the imposed acute psychosocial stress.

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“…78 Studies using multi-variant serum analysis suggest an association between psychological stress and OS. 79,80 The stressful situations during the COVID-19 pandemic increases as an essential part of the body's stress response and chronic increase of cortisol may have deleterious impact on the mental and physical health of adolescent. 81 A meta-analysis of 11 studies (5 observational studies and 6 case reports) showed a significantly high level of cortisol in serum of patients with severe SARS-CoV-2 infection.…”

Section: Covid-19 Pandemic Generates Psychological Stress Markersmentioning

confidence: 99%

“…The SARS-CoV-2 -mediated infection, inflammation, anxiety and stress generate high level of ROS that cause OS in critically ill and vulnerable patients. 4,79,80 High circulating levels of ROS may have the potential impact on the oocyte quality and ovarian functions in SARS-CoV-2 infected women. 102 For instance, high levels of ROS deplete ovarian reserve and generate pathological conditions that result in the onset of ovarian diseases.…”

Section: High Level Ros Affect Ovarian Functionsmentioning

confidence: 99%

Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection

Yadav,

Pandey,

Premkumar

et al. 2024

Reviews in Medical Virology

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was reported in December 2019 and rapidly became a pandemic as coronavirus disease 2019 (COVID‐19). Apart from other organs, presence of specific receptor angiotensin‐converting enzyme (ACE2) and corresponding proteases such as transmembrane serine protease 2, basigin and cysteine protease cathepsin L make follicular somatic cells as well as oocyte as potential targets for SARS‐CoV‐2 infection. The SARS‐CoV‐2 causes inflammation and hypoxia that generate reactive oxygen species (ROS) in critically ill patients. In addition, a large number of casualties and insecurity of life due to repeated waves of SARS‐CoV‐2 infection generate psychological stress and cortisol resulting in the further generation of ROS. The excess levels of ROS under physiological range cause meiotic instability, while high levels result in oxidative stress that trigger various death pathways and affect number as well as quality of follicular oocytes. Although, emerging evidence suggests that the SARS‐CoV‐2 utilises cellular machinery of ovarian follicular cells, generates ROS and impairs quality of follicular oocytes, the underlying mechanism of viral entry into host cell and its negative impact on the follicular oocyte remains poorly understood. Therefore, this review summarises emerging evidence on the presence of cellular machinery for SARS‐CoV‐2 in ovarian follicles and the potential negative impact of viral infection on the follicular oocytes that affect ovarian functions in critically ill and stressed women.

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The acute effect of psychosocial stress on the level of oxidative stress in children

Cited by 6 publications

References 32 publications

NOX2 as a Biomarker of Academic Performance: Evidence from University Students during Examination

NOX2 as a Biomarker of Academic Performance: Evidence from University Students during Examination

Association of acute psychosocial stress with oxidative stress: Evidence from serum analysis

Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection

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