The acute effect of the antioxidant drug “U-74389G” on mean platelet volume levels during hypoxia reoxygenation injury in rats

Tsompos, Constantinos; Panoulis, Constantinos; Toutouzas, Konstantinos; Triantafyllou, Aggeliki; Zografos, George; Papalois, Αpostolos

doi:10.1016/j.pbj.2016.10.003

Cited by 6 publications

(8 citation statements)

References 36 publications

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“…The unique available study investigating the increasing effect of U-74389G on PCTl was the preliminary one [1]. Although the most famous activities of neuroprotection and membrane-stabilization properties, it accumulates in the cell membrane, protecting vascular endothelium from peroxidative damage but hardly penetrates the blood-brain barrier.…”

Section: Discussionmentioning

confidence: 99%

“…The Vet licenses under 3693/12-11-2010 & 14/10-1-2012 numbers, the granting company and the experiment location are mentioned in preliminary references [1,2]. The human animal…”

Section: Animal Preparationmentioning

confidence: 99%

“…U-74389G is not famous for its increasing [1] capacity (p-value=0.0712). U-74389G as a novel antioxidant factor, implicates exactly only 255 published studies.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Opposite Capacities of Erythropoietin and U-74389G on Platelet Crit Levels

Tsompos¹

2017

MADD

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Aim: This study calculated the opposite capacities of 2 drugs: the erythropoietin (Epo) and the antioxidant drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the platelet crit (PCT) levels alterations, after the respective drug usage in an induced hypoxia reoxygenation animal experiment. Materials and methods:The 2 main experimental endpoints at which the PCT levels (PCTl) were evaluated were the 60th reoxygenation min (for the groups A, C and E) and the 120th reoxygenation min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, groups C and D after Epo administration; whereas groups E and F after U-74389G administration. Results:The first preliminary study of Epo non significantly decreased the PCTl by 6.88% ± 3.69% (p-value=0.0615). Also, the second preliminary study of U-74389G non-significantly increased the PCTl by 6.73% ± 37.45% (p-value=0.0712). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that U-74389G has opposite acute effect than Epo (p-value=0.0000). Conclusion:The anti-oxidant capacities of U-74389G enhance the acute increasing properties on PCTl than epo (p-value=0.0000).

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Section: Discussionmentioning

confidence: 99%

“…The Vet licenses under 3693/12-11-2010 & 14/10-1-2012 numbers, the granting company and the experiment location are mentioned in preliminary references [1,2]. The human animal…”

Section: Animal Preparationmentioning

confidence: 99%

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Investigation of the Opposite Capacities of Erythropoietin and U-74389G on Platelet Crit Levels

Tsompos¹

2017

MADD

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“…The detailed anesthesiologic technique is described in related references. [15][16][17] Oxygen supply, electrocardiogram and acidometry were continuously provided during whole experiment performance. The protocol of HR was followed.…”

Section: Aimmentioning

confidence: 99%

The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

Tsompos¹,

Panoulis²,

Toutouzas³

et al. 2016

Folia Medica

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The AIM of this experimental study was to evaluate the effect of the antioxidant drug "U-74389G" in a rat model of hypoxia reoxygenation (HR) using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW) levels. MATERIALS AND METHODS: 40 rats of a mean weight of 231.875 g were employed in the study. RDW levels were determined at 60 min (groups A and C) and at 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G. RESULTS: demonstrated that U-74389G administration signifi cantly decreased the RDW levels by 4.96% + 2.27% (p = 0.0175). Reoxygenation time non-signifi cantly decreased the RDW levels by 0.27% + 2.41% (p = 0.8889). Together, U-74389G administration and reoxygenation time nonsignifi cantly decreased the RDW levels by 2.54% + 1.39% (p = 0.0679). CONCLUSIONS: U-74389G administration particulary in concert without reperfusion declines the RDW levels even within the short -time context of 1.5 hours reperfusion. Key words: hypoxia, U-74389G, red blood cell distribution width, reoxygenation Folia Medica 2015;57(3&4):235-242Copyright © 2015 Medical University, Plovdiv РЕЗЮМЕ ЦЕЛЬЮ настоящей работы является исследование эффективности антиоксиданта U-74389G в модели гипоксии и реоксигенации с использованием протокола предыдущих исследований. Эффективность лечения была оценена путём измерения среднего отклонения распределения эритроцитов (ОРЭ). МАТЕРИАЛЫ И МЕТОДЫ: Исследование проводилось на 40 крысах средним весом 231.875 g. Среднее распределение эритроцитов было измерено через 60 минут (группы А и В) и через 120 минут (группы Б и Г) после начала реоксигенации. Лекарственный продукт U-74389G ввели только животным из групп В и Г, в группах А и Б его не применяли. РЕЗУЛЬТАТЫ: Результаты показывают, что U-74389G сигнификантно понижает ОРЭ на 4.96% + 2.27% (p = 0.0175). Время реоксигенации понижает ОРЭ несигнификантно на 0.27% + 2.41% (p = 0.8889). В комбинации U-74389G и реоксигенация понижают ОРЭ несигнификантно на 2.54% + 1.39% (p = 0.0679). ЗАКЛЮЧЕНИЕ: Применение U-74389G и особенно его взаимодействие с временем для реперфузии понижает ОРЭ, даже и за время короткой реперфузии в рамках 1.5 часа. Medica 2015;57(3&4):235-242 Ключевые слова: гипоксия, U-74389G, отклонение распределения эритроцитов, реоксигенация Folia

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“…Эксперимент начинали с премедикации с последующим наркозом. Подробная анестезиологическая техника описана нами ранее [3][4][5]. Непрерывную подачу кислорода обеспечивали в течение всего хода эксперимента.…”

Section: описание медицинского вмешательстваunclassified

The Effect of the Antioxidant Drug U-74389G on Magnesium Levels During Hypoxia–Reoxygenation Injury in Rats

et al. 2015

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Objective: The aim of this experimental study was to examine the effect of the antioxidant drug U-74389G in a rat model of hypoxia reoxygenation using the previously established protocol. Effects of treatments were evaluated by magnesium (Mg2+) levels in blood. Methods: Nonrandomized controlled study was performed. Mg2+ levels were determined in 60 min (groups A and C) and 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G. Results: 40 rats 1618 weeks old of a mean weight of 2312 g were employed in the study. It is demonstrated that U-74389G administration did not alter the Mg2+ levels (decrease in Mg2+ concentration was 0.282.75%; p =0.917). Reoxygenation non-significantly increased the Mg2+ levels by 4.272.66% (p =0.107). Together, the U-74389G administration and reoxygenation non-significantly increased the Mg2+ levels by 0.361.64% (p =0.823). Conclusion: U-74389G administration, alone or in concert with reoxygenation did not significantly affect Mg2+ level in blood after experimental hypoxia in rats.

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The acute effect of the antioxidant drug “U-74389G” on mean platelet volume levels during hypoxia reoxygenation injury in rats

Cited by 6 publications

References 36 publications

Investigation of the Opposite Capacities of Erythropoietin and U-74389G on Platelet Crit Levels

Investigation of the Opposite Capacities of Erythropoietin and U-74389G on Platelet Crit Levels

The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

The Effect of the Antioxidant Drug U-74389G on Magnesium Levels During Hypoxia–Reoxygenation Injury in Rats

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